41 Publications (Page 1 of 2)
2013
Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects.
Simmons, Jon D⋅Lee, Yann-Leei⋅Mulekar, Sujata⋅Kuck, Jamie L⋅Brevard, Sidney B⋅Gonzalez, Richard P⋅Gillespie, Mark and Richards, William O
Annals of surgery, vol. 258, (no. 4), pp. 591-6; discussion 596-8, 2013/Oct. | Journal Article
 
Mitochondria in Hypoxic Pulmonary Vasoconstriction: Potential Importance of Compartmentalized Reactive Oxygen Species Signaling
Gillespie, Mark⋅Al Mehdi, Abu Bakr and McMurtry, Ivan F
American Journal of Respiratory and Critical Care Medicine, vol. 187, (no. 4), pp. 338-40, Feb 15, 2013. | Journal Article
 
Mitochondrial DNA damage mediates hyperoxic dysmorphogenesis in rat fetal lung explants.
Gebb, Sarah A⋅De Coux, Ashley⋅Waggoner, Alicia⋅Wilson, Glenn L and Gillespie, Mark
Neonatology, vol. 103, (no. 2), pp. 91-7, 2013. | Journal Article
 
Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.
Hashizume, Masahiro⋅Mouner, Marc⋅Chouteau, Joshua M⋅Gorodnya, Olena M⋅Ruchko, Mykhaylo V⋅Potter, Barry J⋅Wilson, Glenn L⋅Gillespie, Mark and Parker, James C
American journal of physiology. Lung cellular and molecular physiology, vol. 304, (no. 4), pp. L287-97, 2013/Feb/15. | Journal Article
2012
Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription.
Al Mehdi, Abu Bakr⋅Pastukh, Viktor M⋅Swiger, Brad M⋅Reed, Darla J⋅Patel, Mita R⋅Bardwell, Gina C⋅Pastukh, Viktoriya V⋅Alexeyev, Mikhail F and Gillespie, Mark
Science signaling, vol. 5, (no. 231), pp. ra47, 2012/Jul/3. | Journal Article
2011
Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs
Chouteau, Joshua M⋅Obiako, Boniface⋅Gorodnya, Olena M⋅Pastukh, Viktor⋅Ruchko, Mykhaylo V⋅Wright, Anthony J⋅Wilson, Glenn L and Gillespie, Mark
American Journal of Physiology, vol. 301, (no. 6), Dec 2011. | Journal Article
 
Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences.
Pastukh, Viktor⋅Zhang, Li⋅Ruchko, Mykhaylo V⋅Gorodnya, Olena⋅Bardwell, Gina C⋅Tuder, Rubin M and Gillespie, Mark
International journal of chronic obstructive pulmonary disease, vol. 6, pp. 209-17, 2011. | Journal Article
 
The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells
Ruchko, Mykhaylo V⋅Gorodnya, Olena M⋅Zuleta, Andres⋅Pastukh, Viktor and Gillespie, Mark
Free Radical Biology and Medicine, vol. 50, (no. 9), pp. 1107-1113, 2011. | Journal Article
2010
Controlled DNA damage and repair in hypoxic signaling
Gillespie, Mark⋅Pastukh, Viktor and Ruchko, Mykhaylo V
Respiratory Physiology & Neurobiology, vol. 174, (no. 3), pp. 244-251, 2010. | Journal Article
 
Polyamine regulatory pathways as pharmacologic targets in pulmonary arterial hypertension.
Gillespie, Mark and Olson, Jack W
Advances in experimental medicine and biology, vol. 661, pp. 375-89, 2010. | Journal Article
2009
Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes
Ruchko, Mykhaylo V⋅Gorodnya, Olena M⋅Pastukh, Viktor⋅Swiger, Brad M⋅Middleton, Natavia S⋅Wilson, Glenn L and Gillespie, Mark
Free Radical Biology and Medicine, vol. 46, (no. 3), pp. 352-359, 2009. | Journal Article
 
Oxidative DNA modifications in hypoxic signaling.
Gillespie, Mark⋅Pastukh, Viktor and Ruchko, Mykhaylo V
Annals of the New York Academy of Sciences, vol. 1177, pp. 140-50, 2009/Oct. | Journal Article
 
Oxidative DNA Modifications in Hypoxic Signaling
Gillespie, Mark⋅Pastukh, Viktor and Ruchko, Mykhaylo V
Annals of the New York Academy of Sciences, vol. 1177, (no. 1), pp. 140-150, 2009. | Journal Article
2008
Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium.
Elzarrad, M K⋅Haroon, Abu⋅Willecke, Klaus⋅Dobrowolski, Radoslaw⋅Gillespie, Mark and Al Mehdi, Abu Bakr
BMC medicine, vol. 6, pp. 20, 2008. | Journal Article
 
Nuclear protein-induced bending and flexing of the hypoxic response element of the rat vascular endothelial growth factor promoter
Breit, Jeffrey F⋅Ault-Ziel, Katheryn⋅Al Mehdi, Abu Bakr and Gillespie, Mark
FASEB journal., vol. 22, (no. 1), pp. 19-29, 2008. | Journal Article
2007
Bending and breaking the code: dynamic changes in promoter integrity may underlie a new mechanism regulating gene expression.
Gillespie, Mark and Wilson, Glenn L
American journal of physiology. Lung cellular and molecular physiology, vol. 292, (no. 1), pp. L1-3, 2007/Jan. | Journal Article
 
Sequence-specific oxidative base modifications in hypoxia-inducible genes
Pastukh, Viktor⋅Ruchko, Mykhaylo V⋅Gorodnya, Olena⋅Wilson, Glenn L and Gillespie, Mark
Free Radical Biology and Medicine, vol. 43, (no. 12), pp. 1616-1626, 2007. | Journal Article
 
The hyperproliferative endothelial cell phenotype in idiopathic pulmonary arterial hypertension.
Stevens, Troy and Gillespie, Mark
American journal of physiology. Lung cellular and molecular physiology, vol. 293, (no. 3), pp. L546-7, 2007/Sep. | Journal Article
2005
Genomic Threats From Physiological Signals in Lung Vascular Cells*
Gillespie, Mark⋅Ziel, Kathryn A⋅Grishko, Valentina⋅Campbell, Clayton C and Wilson, Glenn L
Chest, vol. 128, (no. 6), pp. 611S-612S, Dec 2005. | Journal Article
 
Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells.
Ruchko, Mykhaylo V⋅Gorodnya, Olena⋅Le Doux, Susan P⋅Alexeyev, Mikhail F⋅Al Mehdi, Abu Bakr and Gillespie, Mark
American journal of physiology. Lung cellular and molecular physiology, vol. 288, (no. 3), pp. L530-5, 2005/Mar. | Journal Article
 
Oxidants in signal transduction: impact on DNA integrity and gene expression
Ziel, Kathryn A⋅Grishko, Valentina⋅Campbell, Clayton C⋅Breit, Jeffrey F⋅Wilson, Glenn L and Gillespie, Mark
FASEB journal, vol. 19, (no. 3), pp. 387-394, 2005. | Journal Article
2004
Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene.
Ziel, Kathryn A⋅Campbell, Clayton C⋅Wilson, Glenn L and Gillespie, Mark
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 18, (no. 9), pp. 986-8, 2004/Jun. | Journal Article
2003
Putrescine transport in hypoxic rat main PASMCs is required for p38 MAP kinase activation
Ruchko, Mykhaylo V⋅Gillespie, Mark⋅Weeks, Reitha S⋅Olson, Jack W and Babal, Pavel
American Journal of Physiology, vol. 28, (no. 1), pp. L179-L186, Jan 2003. | Journal Article
 
Putrescine transport in hypoxic rat main PASMCs is required for p38 MAP kinase activation.
Ruchko, Mykhaylo V⋅Gillespie, Mark⋅Weeks, Reitha S⋅Olson, Jack W and Babal, Pavel
American journal of physiology. Lung cellular and molecular physiology, vol. 284, (no. 1), pp. L179-86, 2003/Jan. | Journal Article
2002
Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.
Dobson, Allison W⋅Grishko, Valentina⋅Le Doux, Susan P⋅Kelley, Mark R⋅Wilson, Glenn L and Gillespie, Mark
American journal of physiology. Lung cellular and molecular physiology, vol. 283, (no. 1), pp. L205-10, 2002/Jul. | Journal Article