Expertise

We are focused on  determining how the subcellular localization and kinetics of cAMP and cGMP signals contribute to the activation of specific downstream targets.

The following are ongoing projects in the lab:

  1. Elucidating the contributions of receptor desensitization and the regulation of cyclase and phosphodiesterase activities in shaping cAMP and cGMP signals in pulmonary endothelial and smooth muscle cells.
  2. Understanding the cellular mechanisms by which localized phosphodiesterase activity regulates endothelial barrier permeability.
  3. Determining the molecular mechanisms underlying synergistic effects of b2 adrenergic agonists and corticosteroids in the treatment of asthma.
  4. Measuring enzyme activity in discrete subcellular locations.
  5. Developing optical approaches for the real time measurement of cyclic nucleotide signals in intact tissue.

Keywords:

  • Second messenger signaling, cell signal modeling.

Expertise: Compartmentalized, cyclic nucleotide-mediated signaling

Past Affiliations

Center for Lung Biology, College of Medicine, University of South Alabama

Assistant Professor, Department of Integrative Biology and Pharmacology, University of Texas Medical School at Houston, University of Texas Health Science Center at Houston (past)

Graduate School of Biomedical Sciences at Houston, University of Texas Health Science Center at Houston (past)

Associate Professor, Department of Pharmacology, College of Medicine, University of South Alabama

Postdoctoral Fellow, Physiology and Biophysics, University of Colorado Health Sciences Center (past)

Postdoctoral Fellow, Cardiovascular Dynamics

Communities
Pharmacology, Engineering
Degrees
PhD, Vanderbilt University, Biomedical Engineering, 1996
MS, Georgia Institute of Technology, Aerospace Engineering, 1990
BAE, Georgia Institute of Technology, Engineering, 1988
Keywords
engineering physiology biophysics
Associations
Biophysical Society
Institute of Electrical and Electronics Engineers
Society of General Physiology