34 Publications (Page 1 of 2)
2014
Mechanisms by which synthetic 6,7-annulated-4-substituted indole compounds with anti-proliferative activity disrupt mitosis and block cytokinesis in human HL-60 tumor cells in vitro.
Perchellet, Jean-Pierre H⋅Perchellet, Elisabeth M⋅Singh, Chingakham R⋅Monnett, Meghan T⋅Studer, Elizabeth R⋅Thornton, Paul D⋅Brown, Neil⋅Hill, David⋅Neuenswander, Ben⋅Lushington, Gerald H⋅Santini, Conrad and Buszek, Keith R
Anticancer research, vol. 34, (no. 4), pp. 1643-55, 2014/Apr. | Journal Article
2012
Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro.
Perchellet, Jean-Pierre H⋅Waters, Andrew M⋅Perchellet, Elisabeth M⋅Thornton, Paul D⋅Brown, Neil⋅Hill, David⋅Neuenswander, Ben⋅Lushington, Gerald H⋅Santini, Conrad⋅Chandrasoma, Nalin and Buszek, Keith R
Anticancer research, vol. 32, (no. 11), pp. 4671-84, 2012/Nov. | Journal Article
2011
Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemia and SK-BR-3 mammary tumor cells in vitro.
Perchellet, Jean-Pierre H⋅Waters, Andrew M⋅Perchellet, Elisabeth M⋅Naganaboina, Vijaya K⋅Chandra, Kusum L⋅Desper, John and Rayat, Sundeep
Anticancer research, vol. 31, (no. 6), pp. 2083-93, 2011/Jun. | Journal Article
2010
Bioactivity and molecular targets of novel substituted quinolines in murine and human tumor cell lines in vitro.
Perchellet, Elisabeth M⋅Crow, Kyle R⋅Gakhar, Gunjan⋅Nguyen, Thu A⋅Shi, Aibin⋅Hua, Duy H and Perchellet, Jean-Pierre H
International journal of oncology, vol. 36, (no. 3), pp. 673-88, 2010/Mar. | Journal Article
 
Synthesis and antiproliferative evaluation of 5-oxo and 5-thio derivatives of 1,4-diaryl tetrazoles
Gundugola, Aditya S⋅Chandra, Kusum L⋅Perchellet, Elisabeth M⋅Waters, Andrew M⋅Perchellet, Jean-Pierre H and Rayat, Sundeep
Bioorganic and Medicinal Chemistry Letters, vol. 20, (no. 13), pp. 3920-3924, 2010. | Journal Article
2009
Novel synthetic inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity that inhibit tumor cell proliferation and are structurally unrelated to existing statins.
Perchellet, Jean-Pierre H⋅Perchellet, Elisabeth M⋅Crow, Kyle R⋅Buszek, Keith R⋅Brown, Neil⋅Ellappan, Sampathkumar⋅Gao, Ge⋅Luo, Diheng⋅Minatoya, Machiko and Lushington, Gerald H
International journal of molecular medicine, vol. 24, (no. 5), pp. 633-43, 2009/Nov. | Journal Article
 
Synthesis, molecular targets, and antitumor activities of substituted tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and nanogels for drug delivery.
Perchellet, Elisabeth M⋅Perchellet, Jean-Pierre H⋅Ganta, Chanran Kumar⋅Troyer, Deryl L⋅Shi, Aibin and Hua, Duy H
Anti-cancer agents in medicinal chemistry, vol. 9, (no. 8), pp. 864-76, 2009/Oct. | Journal Article
2008
Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach.
Brown, Neil⋅Gao, Ge⋅Minatoya, Machiko⋅Xie, Baohan⋅Vandervelde, David⋅Lushington, Gerald H⋅Perchellet, Jean-Pierre H⋅Perchellet, Elisabeth M⋅Crow, Kyle R and Buszek, Keith R
Journal of combinatorial chemistry, vol. 10, (no. 5), pp. 628-31, 2008 Sep-Oct. | Journal Article
 
Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis
Brown, Neil⋅Xie, Baohan⋅Markina, Nataliya⋅VanderVelde, David⋅Perchellet, Jean-Pierre H⋅Perchellet, Elisabeth M⋅Crow, Kyle R and Buszek, Keith R
Bioorganic and Medicinal Chemistry, vol. 18, (no. 17), pp. 4876-4879, 2008. | Journal Article
 
Total syntheses of (+/-)-ovalicin, C4(S *)-isomer, and its C5-analogs and anti-trypanosomal activities.
Hua, Duy H⋅Zhao, Huiping⋅Battina, Srinivas K⋅Lou, Kaiyan⋅Jimenez, Ana L⋅Desper, John⋅Perchellet, Elisabeth M⋅Perchellet, Jean-Pierre H and Chiang, Peter K
Bioorganic & medicinal chemistry, vol. 16, (no. 9), pp. 5232-46, 2008/May/1. | Journal Article
 
Total syntheses of (+/-)-ovalicin, C4(S super(*))-isomer, and its C5- analogs and anti-trypanosomal activities
Hua, Duy H⋅Zhao, Huiping⋅Battina, Srinivas K⋅Lou, Kaiyan⋅Jimenez, Ana L⋅Desper, John⋅Perchellet, Elisabeth M⋅Perchellet, Jean-Pierre H and Chiang, Peter K
Bioorganic and Medicinal Chemistry, vol. 16, (no. 9), pp. 5232-5246, 2008. | Journal Article
2007
Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.
Perchellet, Elisabeth M⋅Wang, Yang⋅Lou, Kaiyan⋅Zhao, Huiping⋅Battina, Srinivas K⋅Hua, Duy H and Perchellet, Jean-Pierre H
Anticancer research, vol. 27, (no. 5A), pp. 3259-71, 2007 Sep-Oct. | Journal Article
 
Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria.
Perchellet, Elisabeth M⋅Wang, Yang⋅Lou, Kaiyan⋅Zhao, Huiping⋅Battina, Srinivas K⋅Hua, Duy H and Perchellet, Jean-Pierre H
International journal of oncology, vol. 31, (no. 5), pp. 1231-41, 2007/Nov. | Journal Article
2006
Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells.
Perchellet, Elisabeth M⋅Ward, Mary M⋅Skaltsounis, Alexios-Leandros⋅Kostakis, Ioannis K⋅Pouli, Nicole⋅Marakos, Panagiotis and Perchellet, Jean-Pierre H
Anticancer research, vol. 26, (no. 4B), pp. 2791-804, 2006 Jul-Aug. | Journal Article
 
Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria.
Wang, Yang⋅Perchellet, Elisabeth M⋅Ward, Mary M⋅Lou, Kaiyan⋅Zhao, Huiping⋅Battina, Srinivas K⋅Wiredu, Bernard⋅Hua, Duy H and Perchellet, Jean-Pierre H
International journal of oncology, vol. 28, (no. 1), pp. 161-72, 2006/Jan. | Journal Article
 
Syntheses, Molecular Targets and Antitumor Activities of Novel Triptycene Bisquinones and 1,4-Anthracenedione Analogs
Hua, Duy H⋅Lou, Kaiyan⋅Battina, Srinivas K⋅Zhao, Huiping⋅Perchellet, Elisabeth M⋅Wang, Yang and Perchellet, Jean-Pierre H
Anti-Cancer Agents in Medicinal Chemistry, vol. 6, (no. 4), pp. 303-318, 2006. | Journal Article
2005
Imidazole-4,5-dicarboxamide derivatives with antiproliferative activity against HL-60 cells.
Perchellet, Elisabeth M⋅Perchellet, Jean-Pierre H and Baures, Paul W
Journal of medicinal chemistry, vol. 48, (no. 19), pp. 5955-65, 2005/Sep/22. | Journal Article
 
Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.
Wang, Yang⋅Perchellet, Elisabeth M⋅Ward, Mary M⋅Lou, Kaiyan⋅Hua, Duy H and Perchellet, Jean-Pierre H
Anti-cancer drugs, vol. 16, (no. 9), pp. 953-67, 2005/Oct. | Journal Article
2004
Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling.
Perchellet, Elisabeth M⋅Wang, Yang⋅Weber, Rebeka L⋅Lou, Kaiyan⋅Hua, Duy H and Perchellet, Jean-Pierre H
Anti-cancer drugs, vol. 15, (no. 10), pp. 929-46, 2004/Nov. | Journal Article
 
Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.
Perchellet, Elisabeth M⋅Wang, Yang⋅Weber, Rebeka L⋅Sperfslage, Bonnie J⋅Lou, Kaiyan⋅Crossland, Justin⋅Hua, Duy H and Perchellet, Jean-Pierre H
Biochemical pharmacology, vol. 67, (no. 3), pp. 523-37, 2004/Feb/1. | Journal Article
 
Total syntheses of (+)-chloropuupehenone and (+)-chloropuupehenol and their analogues and evaluation of their bioactivities.
Hua, Duy H⋅Huang, Xiaodong⋅Chen, Yi⋅Battina, Srinivas K⋅Tamura, Masafumi⋅Noh, Sang K⋅Koo, Sung I⋅Namatame, Ichiji⋅Tomoda, Hiroshi⋅Perchellet, Elisabeth M and Perchellet, Jean-Pierre H
The Journal of organic chemistry, vol. 69, (no. 18), pp. 6065-78, 2004/Sep/3. | Journal Article
2003
Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities.
Wang, Buna⋅Perchellet, Elisabeth M⋅Wang, Yang⋅Tamura, Masafumi⋅Hua, Duy H and Perchellet, Jean-Pierre H
Anti-cancer drugs, vol. 14, (no. 7), pp. 503-14, 2003/Aug. | Journal Article
2002
Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro.
Perchellet, Elisabeth M⋅Sperfslage, Bonnie J⋅Wang, Yang⋅Huang, Xiaodong⋅Tamura, Masafumi⋅Hua, Duy H and Perchellet, Jean-Pierre H
Anti-cancer drugs, vol. 13, (no. 6), pp. 567-81, 2002/Jul. | Journal Article
 
Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines.
Wang, Yang⋅Perchellet, Elisabeth M⋅Tamura, Masafumi⋅Hua, Duy H and Perchellet, Jean-Pierre H
Cancer letters, vol. 188, (no. 1-2), pp. 73-83, 2002/Dec/15. | Journal Article
2001
Quinone isomers of the WS-5995 antibiotics: synthetic antitumor agents that inhibit macromolecule synthesis, block nucleoside transport, induce DNA fragmentation, and decrease the growth and viability of L1210 leukemic cells more effectively than ellagic acid and genistein in vitro.
Perchellet, E M⋅Sperfslage, B J⋅Qabaja, G⋅Jones, G B and Perchellet, Jean-Pierre H
Anti-cancer drugs, vol. 12, (no. 5), pp. 401-17, 2001/Jun. | Journal Article