217 Publications (Page 1 of 9)
2023
A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease
Visvanathan, Ramya⋅Visvanathan, Ramya⋅Utsuki, Tadanobu⋅Utsuki, Tadanobu⋅Beck, Daniel E.⋅Beck, Daniel E.⋅Lendy, Emma⋅Lendy, Emma⋅Sun, Kuai-lin⋅Sun, Kuai-lin⋅Liu, Yinghui⋅Liu, Yinghui⋅Hering, Kirk W.⋅Hering, Kirk W.⋅Mesecar, Andrew⋅Mesecar, Andrew⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Putt, Karson S. and Putt, Karson S.
SLAS discovery, vol. 28, (no. 4), pp. 179, 2023-06-01. | Journal Article
 
Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
Wang, Xu⋅Yang, Chao⋅Wang, Xuejie⋅Miao, Jinmin⋅Chen, Weitao⋅Zhou, Yiren⋅Xu, Ying⋅An, Yongyan⋅Cheng, Aifang⋅Ye, Wenkang⋅Chen, Mengxian⋅Song, Dong⋅Yuan, Xue⋅Wang, Jiguang⋅Qian, Peiyuan⋅Wu, Angela Ruohao⋅Zhang, Zhong-Yin and Liu, Kai
Neuron (Cambridge, Mass.), vol. 111, (no. 2), pp. 255.e7, 2023-01-18. | Journal Article
 
Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion
Damayanti, Nur P⋅Saadatzadeh, M Reza⋅Dobrota, Erika⋅Ordaz, Josue D⋅Bailey, Barbara J⋅Pandya, Pankita H⋅Bijangi-Vishehsaraei, Khadijeh⋅Shannon, Harlan E⋅Alfonso, Anthony⋅Coy, Kathy⋅Trowbridge, Melissa⋅Sinn, Anthony L⋅Zhang, Zhong-Yin⋅Gallagher, Rosa I⋅Wulfkuhle, Julia⋅Petricoin, Emanuel⋅Richardson, Angela M⋅Marshall, Mark S⋅Lion, Alex⋅Ferguson, Michael J⋅Balsara, Karl E and Pollok, Karen E
Scientific reports, vol. 13, (no. 1), pp. 9163, 20230606. | Journal Article
 
Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue
Prabhu, Lakshmi⋅Prabhu, Lakshmi⋅Martin, Matthew⋅Martin, Matthew⋅Chen, Lan⋅Chen, Lan⋅Demir, Özlem⋅Demir, Özlem⋅Jin, Jiamin⋅Jin, Jiamin⋅Huang, Xiumei⋅Huang, Xiumei⋅Motolani, Aishat⋅Motolani, Aishat⋅Sun, Mengyao⋅Sun, Mengyao⋅Jiang, Guanglong⋅Jiang, Guanglong⋅Nakshatri, Harikrishna⋅Nakshatri, Harikrishna⋅Fishel, Melissa L.⋅Fishel, Melissa L⋅Sun, Steven⋅Sun, Steven⋅Safa, Ahmad⋅Safa, Ahmad⋅Amaro, Rommie E⋅Amaro, Rommie E.⋅Kelley, Mark R⋅Kelley, Mark R.⋅Liu, Yunlong⋅Liu, Yunlong⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Lu, Tao and Lu, Tao
Genes & diseases, vol. 10, (no. 1), pp. 283, 2023-01-01. | Journal Article
 
Nano-DESI Mass Spectrometry Imaging of Proteoforms in Biological Tissues with High Spatial Resolution
Yang, Manxi⋅Yang, Manxi⋅Yang, Manxi⋅Unsihuay, Daisy⋅Unsihuay, Daisy⋅Unsihuay, Daisy⋅Hu, Hang⋅Hu, Hang⋅Hu, Hang⋅Nguele Meke, Frederick⋅Nguele Meke, Frederick⋅Nguele Meke, Frederick⋅Qu, Zihan⋅Qu, Zihan⋅Qu, Zihan⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Laskin, Julia⋅Laskin, Julia and Laskin, Julia
Analytical chemistry (Washington), vol. 95, (no. 12), pp. 5222, 20230328. | Journal Article
 
PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
Chen, Hongxia⋅Chen, Hongxia⋅Chen, Hongxia⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Xiao, Shiyu⋅Xiao, Shiyu⋅Xiao, Shiyu⋅Cai, Wenjie⋅Cai, Wenjie⋅Cai, Wenjie⋅Barajas, Sergio⋅Barajas, Sergio⋅Barajas, Sergio⋅Chen, Sisi⋅Chen, Sisi⋅Chen, Sisi⋅Miao, Jinmin⋅Miao, Jinmin⋅Miao, Jinmin⋅Meke, Frederick Nguele⋅Meke, Frederick Nguele⋅Meke, Frederick Nguele⋅Vemula, Sasidhar⋅Vemula, Sasidhar⋅Vemula, Sasidhar⋅Ropa, James P.⋅Ropa, James P.⋅Ropa, James P.⋅Croop, James M.⋅Croop, James M.⋅Croop, James M.⋅Boswell, H. Scott⋅Boswell, H. Scott⋅Boswell, H. Scott⋅Wan, Jun⋅Wan, Jun⋅Wan, Jun⋅Jia, Yuzhi⋅Jia, Yuzhi⋅Jia, Yuzhi⋅Liu, Huiping⋅Liu, Huiping⋅Liu, Huiping⋅Li, Loretta S.⋅Li, Loretta S.⋅Li, Loretta S.⋅Altman, Jessica K.⋅Altman, Jessica K.⋅Altman, Jessica K.⋅Eklund, Elizabeth A.⋅Eklund, Elizabeth A.⋅Eklund, Elizabeth A.⋅Ji, Peng⋅Ji, Peng⋅Ji, Peng⋅Tong, Wei⋅Tong, Wei⋅Tong, Wei⋅Band, Hamid⋅Band, Hamid⋅Band, Hamid⋅Huang, Danny T.⋅Huang, Danny T.⋅Huang, Danny T.⋅Platanias, Leonidas C.⋅Platanias, Leonidas C.⋅Platanias, Leonidas C.⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Liu, Yan⋅Liu, Yan and Liu, Yan
Blood, vol. 141, (no. 3), pp. 259, 2023-01-19. | Journal Article
2022
An Integrated Proteomic Strategy to Identify SHP2 Substrates
Zhu, Peipei⋅Wu, Xiaofeng⋅Zhang, Ruo-Yu⋅Hsu, Chuan-Chih⋅Zhang, Zhong-Yin and Tao, W. Andy
Journal of proteome research, vol. 21, (no. 10), pp. 2525, 2022-10-07. | Journal Article
 
Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions
Blaine, Arryn T.⋅Miao, Yiming⋅Yuan, Jinling⋅Palant, Sophia⋅Liu, Rebecca J.⋅Zhang, Zhong-Yin and van Rijn, Richard. M.
Frontiers in pharmacology, vol. 13, pp. 914651, 2022-08-11. | Journal Article
 
High-throughput screening strategies for space-based radiation countermeasure discovery
Putt, Karson S.⋅Du, Yuhong⋅Fu, Haian and Zhang, Zhong-Yin
Life sciences in space research, vol. 35, pp. 104, November 2022. | Journal Article
 
PTPN22: structure, function, and developments in inhibitor discovery with applications for immunotherapy
Jassim, Brenson A.⋅Jassim, Brenson A.⋅Jassim, Brenson A.⋅Lin, Jianping⋅Lin, Jianping⋅Lin, Jianping⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin and Zhang, Zhong-Yin
Expert opinion on drug discovery, vol. 17, (no. 8), pp. 837, 2022-08-03. | Journal Article
 
Purification and cryo-EM structure determination of VCP/p97 dodecamers from mammalian and bacterial cells
Yu, Guimei⋅Bai, Yunpeng and Zhang, Zhong-Yin
STAR protocols, vol. 3, (no. 2), pp. 101339, 2022-Jun-17. | Journal Article
 
Structure Based Design of Active Site-Directed, Highly Potent, Selective, and Orally Bioavailable LMW-PTP Inhibitors
He, Rongjun⋅He, Rongjun⋅Wang, Jifeng⋅Wang, Jifeng⋅Yu, Zhi-Hong⋅Yu, Zhi-Hong⋅Moyers, Julie S.⋅Moyers, Julie S.⋅Michael, M. Dodson⋅Michael, M. Dodson⋅Durham, Timothy B.⋅Durham, Timothy B.⋅Cramer, Jeff W⋅Cramer, Jeff W⋅Qian, Yuewei⋅Qian, Yuewei⋅Lin, Amy⋅Lin, Amy⋅Wu, Li⋅Wu, Li⋅Noinaj, Nicholas⋅Noinaj, Nicholas⋅Barrett, David G.⋅Barrett, David G.⋅Zhang, Zhong-Yin and Zhang, Zhong-Yin
Journal of medicinal chemistry, vol. 65, (no. 20), pp. 13909, 20221005. | Journal Article
 
Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells
Medellin, Brenda⋅Medellin, Brenda⋅Yang, Wanjie⋅Yang, Wanjie⋅Konduri, Srihari⋅Konduri, Srihari⋅Dong, Jiajun⋅Dong, Jiajun⋅Irani, Seema⋅Irani, Seema⋅Wu, Haoyi⋅Wu, Haoyi⋅Matthews, Wendy L⋅Matthews, Wendy L⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Siegel, Dionico⋅Siegel, Dionico⋅Zhang, Yan and Zhang, Yan
Journal of medicinal chemistry, vol. 65, (no. 1), pp. 519, 2022-01-13. | Journal Article
 
Tumor Cell-Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer
Chen, Hao⋅Chen, Hao⋅Chen, Hao⋅Chen, Hao⋅Cresswell, Gregory M⋅Cresswell, Gregory M⋅Cresswell, Gregory M⋅Cresswell, Gregory M⋅Libring, Sarah⋅Libring, Sarah⋅Libring, Sarah⋅Libring, Sarah⋅Ayers, Mitchell G⋅Ayers, Mitchell G⋅Ayers, Mitchell G⋅Ayers, Mitchell G⋅Miao, Jinmin⋅Miao, Jinmin⋅Miao, Jinmin⋅Miao, Jinmin⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Solorio, Luis⋅Solorio, Luis⋅Solorio, Luis⋅Solorio, Luis⋅Ratliff, Timothy L⋅Ratliff, Timothy L⋅Ratliff, Timothy L⋅Ratliff, Timothy L⋅Wendt, Michael K⋅Wendt, Michael K⋅Wendt, Michael K and Wendt, Michael K
Cancer research communications, vol. 2, (no. 10), pp. 1118, 20221003. | Journal Article
2021
Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription
Kim, Wantae⋅Kim, Wantae⋅LeBlanc, Blase⋅LeBlanc, Blase⋅Matthews, Wendy L⋅Matthews, Wendy L.⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Zhang, Yan and Zhang, Yan
Current opinion in chemical biology, vol. 63, pp. 77, 2021-08-01. | Journal Article
 
Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation
Yu, Guimei⋅Yu, Guimei⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Li, Kunpeng⋅Li, Kunpeng⋅Amarasinghe, Ovini⋅Amarasinghe, Ovini⋅Jiang, Wen⋅Jiang, Wen⋅Zhang, Zhong-Yin and Zhang, Zhong-Yin
iScience, vol. 24, (no. 11), pp. 103310, 2021-11-19. | Journal Article
 
Functional interrogation and therapeutic targeting of protein tyrosine phosphatases
Krabill, Aaron D and Zhang, Zhong-Yin
Biochemical Society transactions, vol. 49, (no. 4), pp. 1734, 20210827. | Journal Article
 
Systemic inhibition of PTPN22 augments anticancer immunity
Ho, Won J⋅Ho, Won Jin⋅Ho, Won Jin⋅Croessmann, Sarah⋅Croessmann, Sarah⋅Croessmann, Sarah⋅Lin, Jianping⋅Lin, Jianping⋅Lin, Jianping⋅Phyo, Zaw H⋅Phyo, Zaw H⋅Phyo, Zaw H⋅Charmsaz, Soren⋅Charmsaz, Soren⋅Charmsaz, Soren⋅Danilova, Ludmila⋅Danilova, Ludmila⋅Danilova, Ludmila⋅Mohan, Aditya A⋅Mohan, Aditya A⋅Mohan, Aditya A⋅Gross, Nicole E⋅Gross, Nicole E⋅Gross, Nicole E⋅Chen, Fangluo⋅Chen, Fangluo⋅Chen, Fangluo⋅Dong, Jiajun⋅Dong, Jiajun⋅Dong, Jiajun⋅Aggarwal, Devesh⋅Aggarwal, Devesh⋅Aggarwal, Devesh⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Wang, Janey⋅Wang, Janey⋅Wang, Janey⋅He, Jing⋅He, Jing⋅He, Jing⋅Leatherman, James M⋅Leatherman, James M⋅Leatherman, James M⋅Yarchoan, Mark⋅Yarchoan, Mark⋅Yarchoan, Mark⋅Armstrong, Todd D⋅Armstrong, Todd D⋅Armstrong, Todd D⋅Zaidi, Neeha⋅Zaidi, Neeha⋅Zaidi, Neeha⋅Fertig, Elana J⋅Fertig, Elana J⋅Fertig, Elana J⋅Denny, Joshua C⋅Denny, Joshua C⋅Denny, Joshua C⋅Park, Ben H⋅Park, Ben H⋅Park, Ben H⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Jaffee, Elizabeth M⋅Jaffee, Elizabeth M and Jaffee, Elizabeth M
The Journal of clinical investigation, vol. 131, (no. 17), pp. 15, 2021-09-01. | Journal Article
2020
Highly Potent and Selective N‑Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B
Ruddraraju, Kasi Viswanatharaju⋅Aggarwal, Devesh⋅Niu, Congwei⋅Baker, Erica Anne⋅Zhang, Ruo-yu⋅Wu, Li and Zhang, Zhong-Yin
Journal of medicinal chemistry, vol. 63, (no. 17), pp. 9227, 2020-09-10. | Journal Article
 
Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis
Li, Qinglin⋅Bai, Yunpeng⋅Lyle, L. Tiffany⋅Yu, Guimei⋅Amarasinghe, Ovini⋅Meke, Frederick Nguele⋅Carlock, Colin and Zhang, Zhong-Yin
Proceedings of the National Academy of Sciences - PNAS, vol. 117, (no. 34), pp. 20548, 2020-08-25. | Journal Article
 
Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2
Zhang, Ruo-Yu⋅Yu, Zhi-Hong⋅Chen, Lan⋅Walls, Chad D.⋅Zhang, Sheng⋅Wu, Li and Zhang, Zhong-Yin
The Journal of biological chemistry, vol. 295, (no. 18), pp. 6201, 2020-05-01. | Journal Article
 
Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation
Zhu, Guangya⋅Xie, Jingjing⋅Kong, Wenna⋅Xie, Jingfei⋅Li, Yichen⋅Du, Lin⋅Zheng, Qiangang⋅Sun, Lin⋅Guan, Mingfeng⋅Li, Huan⋅Zhu, Tianxin⋅He, Hao⋅Liu, Zhenying⋅Xia, Xi⋅Kan, Chen⋅Tao, Youqi⋅Shen, Hong C.⋅Li, Dan⋅Wang, Siying⋅Yu, Yongguo⋅Yu, Zhi-Hong⋅Zhang, Zhong-Yin⋅Liu, Cong and Zhu, Jidong
Cell, vol. 183, (no. 2), pp. 502.e18, 2020-10-15. | Journal Article
 
SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer
Chen, Hao⋅Chen, Hao⋅Chen, Hao⋅Chen, Hao⋅Libring, Sarah⋅⋅Libring, Sarah⋅Libring, Sarah⋅Ruddraraju, Kasi Viswanatharaju⋅Ruddraraju, Kasi Viswanatharaju⋅Ruddraraju, Kasi Viswanatharaju⋅Miao, Jinmin⋅Miao, Jinmin⋅Miao, Jinmin⋅Solorio, Luis⋅Solorio, Luis⋅Solorio, Luis⋅Solorio, Luis⋅Zhang, Zhong-Yin⋅Zhong-Yin, Zhang⋅Zhang, Zhong-Yin⋅Zhang, Zhong-Yin⋅Wendt, Michael K⋅Wendt, Michael K⋅Wendt, Michael K and Wendt, Michael K
Oncogene, vol. 39, (no. 49), pp. 7180, 2020-12-03. | Journal Article
 
Therapeutic Targeting of Protein Tyrosine Phosphatases from Mycobacterium tuberculosis
Ruddraraju, Kasi Viswanatharaju⋅Aggarwal, Devesh and Zhang, Zhong-Yin
Microorganisms (Basel), vol. 9, (no. 1), pp. 14, 20201223. | Journal Article
2019
First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors
Li, Yangxiong⋅Gardner, Jessi J⋅Fortney, Katherine R⋅Leus, Inga V⋅Bonifay, Vincent⋅Zgurskaya, Helen I⋅Pletnev, Alexandre A⋅Zhang, Sheng⋅Zhang, Zhong-Yin⋅Gribble, Gordon W⋅Spinola, Stanley M and Duerfeldt, Adam S
Bioorganic & Medicinal Chemistry Letters, vol. 29, (no. 14), pp. 1841, 2019-07-15. | Journal Article