Dr. Hollenhorst’s research focuses on the mechanisms that allow genome sequence to dictate the transcriptional control of gene expression.
My work focuses the ETS family of human transcription factors. 50-70% of all prostate cancers harbor a chromosomal rearrangement that results in the over-expression of one of four ETS genes (ERG, ETV1, ETV4, or ETV5).
Our research focuses on an important basic science question and an important cancer biology question.
- Basic Science: How do transcription factors with similar DNA binding domains achieve specificity
- Cancer Biology: What are the molecular mechanisms that allow transcription factors expressed due to gene fusions to promoter cancer?
- mechanisms of transcription factor specificity in cancer