Expertise

Specialization:

  • Protein misassembly, Parkinson's disease

Research Interests:

  • Model illustrating cellular phenomena that promote or inhibit a-Syn self-assembly

Examples of questions addressed by our studies include:

  1. What are molecular mechanisms (e.g. intermolecular interactions, conformational changes) underlying the formation of neurotoxic aSyn aggregates?
  2. How do post-translational modifications (e.g. oxidation, phosphorylation, nitration) modulate aSyn aggregation and neurotoxicity?
  3. What are cellular factors (e.g. antioxidant proteins, chaperones, proteins involved in lysosomal autophagy) that modulate aSyn aggregation and neurotoxicity?
  4. Which cellular functions (e.g. mitochondrial respiration, lysosomal autophagy) are disrupted by neurotoxic forms of aSyn?
  5. Can we identify chemical entities that interfere with aSyn aggregation or neurotoxicity or that enhance the neuroprotective function of DJ-1?

Interests:

  • Protein misassembly in neurodegenerative disorders
  • Protein-lipid interactions in amyloid diseases
  • Post-translational modifications in aging and age-related neurodegenerative disorders
  • Mitochondrial proteins in age-related neurodegenerative disorders
  • Antioxidant response pathways in aging and age-related neurodegenerative disorders
  • Molecular chaperones in aging and age-related neurodegenerative diseases
  • Autophagy in aging and age-related neurodegenerative diseases
  • Intracellular transport mechanisms in neurodegenerative disorders
  • Small-molecule inhibitors of protein aggregation, neurodegeneration
  • Dietary components as inhibitors of protein aggregation, neurodegeneration
  • Glia-neuron interactions in neurodegenerative disorders
  • Mechanisms of neurodegeneration associated with methamphetamine intoxication
  • Epigenetic changes in CNS disorders

Area of Research:

  • Biophysical and Computational Chemistry
  • Genomics and Systems Biology
  • Medicinal Chemistry and Chemical Biology
  • Molecular and Cellular Pharmacology

Disease Area:

  • Neuroscience
  • Cancer
  • Metabolism
  • Aging
  • Infectious Disease
  • Immunology
  • Drug Addiction
  • Alzheimer's Disease
  • Rare Diseases

The Rochet lab has a long-standing interest in neurodegenerative disorders including PD, DLB, and AD.


Subject Areas:

  • aging
  • neuroscience

Area of research:

  • Molecular and Cellular Pharmacology

Expertise:

  • Medicinal Chem
Affiliations

Professor, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University

Professor, Integrative Neuroscience, Graduate School, Purdue University

Adjunct Professor, IUSM West Lafayette, Indiana University School of Medicine

Department of Speech, Language, and Hearing Sciences, College of Health and Human Sciences, Purdue University

Bindley Bioscience Center, Discovery Park District, Office of Research, Purdue University

Department of Nutrition Science, College of Health and Human Sciences, Purdue University

Past Affiliations

Associate Professor, Department of Nutrition Science, College of Health and Human Sciences, Purdue University (past)

Associate Professor, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University (past)

Assistant Professor, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University (past)

Assistant Professor, Integrative Neuroscience Graduate Program, Graduate School, Purdue University (past)

Courtesy Associate Professor, Department of Nutrition Science, College of Health and Human Sciences, Purdue University (past)

Communities
Pharmacology, Neuroscience, Chemistry
Degrees
PhD, University of Alberta, Biochemistry, 1998
BS, University of Alberta, Biochemistry, 1991
Keywords
parkinson's disease amyotrophic lateral sclerosis biochemistry & molecular biology neuroscience biophysics atomic force microscopy
Languages
English, French
Associations
American Chemical Society