27 Publications (Page 1 of 2)
2022
PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis
Blanco, Daniel Bastardo⋅Chapman, Nicole M.⋅Raynor, Jana L.⋅Xu, Chengxian⋅Su, Wei⋅KC, Anil⋅Li, Wei⋅Lim, Seon Ah⋅Schattgen, Stefan⋅Shi, Hao⋅Risch, Isabel⋅Sun, Yu⋅Dhungana, Yogesh⋅Kim, Yunjung⋅Wei, Jun⋅Rankin, Sherri⋅Neale, Geoffrey⋅Thomas, Paul G.⋅Yang, Kai and Chi, Hongbo
Nature Cell Biology, vol. 24, (no. 11), pp. 1642-1654, Nov 2022. | Journal Article
2021
BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses.
Xu, Chengxian⋅Xu, Chengxian⋅Fu, Yongyao⋅Fu, Yongyao⋅Liu, Sheng⋅Liu, Sheng⋅Trittipo, Jack⋅Trittipo, Jack⋅Lu, Xiaoyu⋅Lu, Xiaoyu⋅Qi, Rong⋅Qi, Rong⋅Du, Hong⋅Du, Hong⋅Yan, Cong⋅Yan, Cong⋅Zhang, Chi⋅Zhang, Chi⋅Wan, Jun⋅Wan, Jun⋅Kaplan, Mark H⋅Kaplan, Mark H⋅Yang, Kai and Yang, Kai
Journal of immunology (Baltimore, Md. : 1950), vol. 206, (no. 9), pp. 2088-2100, May 1, 2021. | Journal Article
 
Combinatorial analyses reveal cellular composition changes have different impacts on transcriptomic changes of cell type specific genes in Alzheimer's Disease
Johnson, Travis S⋅Xiang, Shunian⋅Dong, Tianhan⋅Huang, Zhi⋅Cheng, Michael⋅Wang, Tianfu⋅Yang, Kai⋅Ni, Dong⋅Huang, Kun and Zhang, Jie
Scientific reports, vol. 11, (no. 1), pp. 353, 2021-Jan-11. | Journal Article
 
The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
Xu, Chengxian⋅Xu, Chengxian⋅Xu, Chengxian⋅Xu, Chengxian⋅Sun, Shaogang⋅Sun, Shaogang⋅Sun, Shaogang⋅Sun, Shaogang⋅Johnson, Travis⋅Johnson, Travis⋅Johnson, Travis⋅Johnson, Travis⋅Qi, Rong⋅Qi, Rong⋅Qi, Rong⋅Qi, Rong⋅Zhang, Siyuan⋅Zhang, Siyuan⋅Zhang, Siyuan⋅Zhang, Siyuan⋅Zhang, Jie⋅Zhang, Jie⋅Zhang, Jie⋅Zhang, Jie⋅Yang, Kai⋅Yang, Kai⋅Yang, Kai and Yang, Kai
Cell reports (Cambridge), vol. 35, (no. 11), pp. 109235, 2021-06-15. | Journal Article
2020
Autophagy modulates CD4 + T-cell lineage recommitment upon pathogen infection
Yang, Kai and Chi, Hongbo
Cellular & molecular immunology, vol. 17, (no. 7), pp. 683, 2020-07-00. | Journal Article
 
Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis
Golomb, Samantha M⋅Golomb, Samantha M⋅Guldner, Ian H⋅Guldner, Ian H⋅Zhao, Anqi⋅Zhao, Anqi⋅Wang, Qingfei⋅Wang, Qingfei⋅Palakurthi, Bhavana⋅Palakurthi, Bhavana⋅Aleksandrovic, Emilija A⋅Aleksandrovic, Emilija A⋅Lopez, Jacqueline A⋅Lopez, Jacqueline A⋅Lee, Shaun W⋅Lee, Shaun W⋅Yang, Kai⋅Yang, Kai⋅Zhang, Siyuan and Zhang, Siyuan
Cell reports (Cambridge), vol. 33, (no. 9), pp. 108438, 2020-12-01. | Journal Article
 
ResTORing barrier function in the skin
Wang, Jocelyn⋅Wang, Jocelyn⋅Kaplan, Mark H⋅Kaplan, Mark H.⋅Yang, Kai and Yang, Kai
(pp. 111-113). Jan 2020
 
STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus
Fu, Yongyao⋅Wang, Jocelyn⋅Panangipalli, Gayathri⋅Ulrich, Benjamin J⋅Koh, Byunghee⋅Xu, Chengxian⋅Kharwadkar, Rakshin⋅Chu, Xiaona⋅Wang, Yue⋅Gao, Hongyu⋅Wu, Wenting⋅Sun, Jie⋅Tepper, Robert S⋅Zhou, Baohua⋅Janga, Sarath Chandra⋅Yang, Kai and Kaplan, Mark H
Nature communications, vol. 11, (no. 1), pp. 4882, 2020-09-28. | Journal Article
 
T follicular regulatory cells and IL-10 promote food antigen-specific IgE
Xie, Markus M⋅Xie, Markus M⋅Xie, Markus M⋅Chen, Qiang⋅Chen, Qiang⋅Chen, Qiang⋅Liu, Hong⋅Liu, Hong⋅Liu, Hong⋅Yang, Kai⋅Yang, Kai⋅Yang, Kai⋅Koh, Byunghee⋅Koh, Byunghee⋅Koh, Byunghee⋅Wu, Hao⋅Wu, Hao⋅Wu, Hao⋅Maleki, Soheila J⋅Maleki, Soheila J⋅Maleki, Soheila J⋅Hurlburt, Barry K⋅Hurlburt, Barry K⋅Hurlburt, Barry K⋅Cook-Mills, Joan⋅Cook-Mills, Joan⋅Cook-Mills, Joan⋅Kaplan, Mark H⋅Kaplan, Mark H⋅Kaplan, Mark H⋅Dent, Alexander L⋅Dent, Alexander L and Dent, Alexander L
The Journal of clinical investigation, vol. 130, (no. 7), pp. 3832, 2020-07-01. | Journal Article
2019
Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity.
Karmaus, Peer W F⋅Chen, Xiang⋅Lim, Seon Ah⋅Herrada, Andrés A⋅Nguyen, Thanh-Long M⋅Xu, Beisi⋅Dhungana, Yogesh⋅Rankin, Sherri⋅Chen, Wenan⋅Rosencrance, Celeste⋅Yang, Kai⋅Fan, Yiping⋅Cheng, Yong⋅Easton, John⋅Neale, Geoffrey⋅Vogel, Peter and Chi, Hongbo
Nature, vol. 565, (no. 7737), pp. 101-105, January 2019. | Journal Article
2017
Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation
Tan, Haiyan⋅Tan, Haiyan⋅Yang, Kai⋅Yang, Kai⋅Li, Yuxin⋅Li, Yuxin⋅Shaw, Timothy I⋅Shaw, Timothy I⋅Wang, Yanyan⋅Wang, Yanyan⋅Blanco, Daniel Bastardo⋅Blanco, Daniel Bastardo⋅Wang, Xusheng⋅Wang, Xusheng⋅Cho, Ji-Hoon⋅Cho, Ji-Hoon⋅Wang, Hong⋅Wang, Hong⋅Rankin, Sherri⋅Rankin, Sherri⋅Guy, Cliff⋅Guy, Cliff⋅Peng, Junmin⋅Peng, Junmin⋅Chi, Hongbo and Chi, Hongbo
Immunity, vol. 46, (no. 3), pp. 503, 2017-03-21. | Journal Article
2016
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
Wei, Jun⋅Wei, Jun⋅Long, Lingyun⋅Long, Lingyun⋅Yang, Kai⋅Yang, Kai⋅Guy, Cliff⋅Guy, Cliff⋅Shrestha, Sharad⋅Shrestha, Sharad⋅Chen, Zuojia⋅Chen, Zuojia⋅Wu, Chuan⋅Wu, Chuan⋅Vogel, Peter⋅Vogel, Peter⋅Neale, Geoffrey⋅Neale, Geoffrey⋅Green, Douglas R⋅Green, Douglas R⋅Chi, Hongbo and Chi, Hongbo
Nature immunology, vol. 17, (no. 3), pp. 285, 2016-Mar. | Journal Article
2015
AMPK Helps T Cells Survive Nutrient Starvation
Yang, Kai and Chi, Hongbo
Immunity (Cambridge, Mass.), vol. 42, (no. 1), pp. 6, 2015-01-20. | Journal Article
 
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
Shrestha, Sharad⋅Shrestha, Sharad⋅Yang, Kai⋅Yang, Kai⋅Guy, Cliff⋅Guy, Cliff⋅Vogel, Peter⋅Vogel, Peter⋅Neale, Geoffrey⋅Neale, Geoffrey⋅Chi, Hongbo and Chi, Hongbo
Nature immunology, vol. 16, (no. 2), pp. 187, 2015-Feb. | Journal Article
2014
Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision.
Wei, Jun⋅Wei, Jun⋅Yang, Kai⋅Yang, Kai⋅Chi, Hongbo and Chi, Hongbo
Journal of immunology (Baltimore, Md. : 1950), vol. 193, (no. 9), pp. 4297-4301, November 1, 2014. | Journal Article
 
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions
Wu, Jinhong⋅Wu, Jinhong⋅Yang, Jialong⋅Yang, Jialong⋅Yang, Kai⋅Yang, Kai⋅Wang, Hongxia⋅Wang, Hongxia⋅Gorentla, Balachandra⋅Gorentla, Balachandra⋅Shin, Jinwook⋅Shin, Jinwook⋅Qiu, Yurong⋅Qiu, Yurong⋅Que, Loretta G⋅Que, Loretta⋅Foster, W M⋅Foster, W.⋅Xia, Zhenwei⋅Xia, Zhenwei⋅Chi, Hongbo⋅Chi, Hongbo⋅Zhong, Xiao-Ping and Zhong, Xiaoping
The Journal of clinical investigation, vol. 124, (no. 4), pp. 1698, 2014-04-01. | Journal Article
 
Metabolic Control of Th17 Cell Generation and CNS Inflammation
Yang, Kai and Chi, Hongbo
Journal of neurology & neurophysiology, vol. Suppl 12, (no. 1), 2014. | Journal Article
 
Tsc1 promotes the differentiation of memory CD8⁺ T cells via orchestrating the transcriptional and metabolic programs
Shrestha, Sharad⋅Shrestha, Sharad⋅Yang, Kai⋅Yang, Kai⋅Wei, Jun⋅Wei, Jun⋅Karmaus, Peer⋅Karmaus, Peer W F⋅Neale, Geoffrey⋅Neale, Geoffrey⋅Chi, Hongbo and Chi, Hongbo
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 41), pp. 14863, 20141014. | Journal Article
2013
T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming
Yang, Kai⋅Yang, Kai⋅Shrestha, Sharad⋅Shrestha, Sharad⋅Zeng, Hu⋅Zeng, Hu⋅Karmaus, Peer W⋅Karmaus, Peer W.F⋅Neale, Geoffrey⋅Neale, Geoffrey⋅Vogel, Peter⋅Vogel, Peter⋅Guertin, David⋅Guertin, David A⋅Lamb, Richard F⋅Lamb, Richard F⋅Chi, Hongbo and Chi, Hongbo
Immunity, vol. 39, (no. 6), pp. 1056, 2013-12-12. | Journal Article
 
Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.
Wang, Yanyan⋅Wang, Yanyan⋅Huang, Gonghua⋅Huang, Gonghua⋅Zeng, Hu⋅Zeng, Hu⋅Yang, Kai⋅Yang, Kai⋅Lamb, Richard F⋅Lamb, Richard F⋅Chi, Hongbo and Chi, Hongbo
Proceedings of the National Academy of Sciences of the United States of America, vol. 110, (no. 50), pp. E4894-E4903, December 10, 2013. | Journal Article
 
Tuning mTOR activity for immune balance
Yang, Kai and Chi, Hongbo
The Journal of clinical investigation, vol. 123, (no. 12), pp. 5004, 2013-Dec. | Journal Article
2012
mTOR and metabolic pathways in T cell quiescence and functional activation.
Yang, Kai⋅Yang, Kai⋅Chi, Hongbo and Chi, Hongbo
Seminars in immunology, vol. 24, (no. 6), pp. 421-428, December 2012. | Journal Article
2011
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
Yang, Kai⋅Yang, Kai⋅Neale, Geoffrey⋅Neale, Geoffrey⋅Green, Douglas R⋅Green, Douglas R⋅He, Weifeng⋅He, Weifeng⋅Chi, Hongbo and Chi, Hongbo
Nature immunology, vol. 12, (no. 9), pp. 897, 2011-Jul-17. | Journal Article
2010
Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification
Shi, He-Xin⋅Yang, Kai⋅Liu, Xing⋅Liu, Xin-Yi⋅Wei, Bo⋅Shan, Yu-Fei⋅Zhu, Lian-Hui and Wang, Chen
Molecular and Cellular Biology, vol. 30, (no. 10), pp. 2436, 20100515. | Journal Article
 
The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells.
Liu, Guangwei⋅Liu, Guangwei⋅Yang, Kai⋅Yang, Kai⋅Burns, Samir⋅Burns, Samir⋅Shrestha, Sharad⋅Shrestha, Sharad⋅Chi, Hongbo and Chi, Hongbo
Nature immunology, vol. 11, (no. 11), pp. 1047-1056, November 2010. | Journal Article