38 Publications (Page 1 of 2)
2024
A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation
Structure of HIV-1 RRE stem-loop II identifies two conformational states of the high-affinity Rev binding site. Nature Communications
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2023
Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction. RSC Medicinal Chemistry
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Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry
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Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation. ChemMedChem
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2022
Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine
Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine. Nature Communications
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Metal retention and replacement in QueD2 protect queuosine-tRNA biosynthesis in metal-starved Acinetobacter baumannii. Proceedings of the National Academy of Sciences
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Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists. Journal of medicinal chemistry
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Structural Analyses of CrtJ and Its B12-Binding Co-Regulators SAerR and LAerR from the Purple Photosynthetic Bacterium Rhodobacter capsulatusDragnea, Vladimira⋅Gonzalez Gutierrez, Giovanni and Bauer, Carl E.Microorganisms, vol. 10, pp. 912.
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2021
Functional asymmetry and chemical reactivity of CsoR family persulfide sensors
OUP accepted manuscript
Nucleic Acids Research. | Journal Article
The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and binds diverse DNA sequences.
Nucleic acids research. | Journal Article
2020
Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPasesBum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Liu, Degang⋅Liu, Degang⋅Gonzalez Gutierrez, Giovanni⋅Gonzalez-Gutierrez, Giovanni⋅Ghozayel, Mona K⋅Ghozayel, Mona K.⋅Xu, David⋅Xu, David⋅Meroueh, Samy O and Meroueh, Samy O.Proceedings of the National Academy of Sciences, vol. 117, pp. 7131–7139.
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Structural basis for persulfide-sensing specificity in a transcriptional regulatorCapdevila, Daiana A⋅Walsh, Brenna J⋅Zhang, Yifan⋅Dietrich, Christopher⋅Gonzalez-Gutierrez, Giovanni and Giedroc, David PNature Chemical Biology.
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Structural determinants of persulfide-sensing specificity in a dithiol-based transcriptional regulatorCapdevila, Daiana A.⋅Walsh, Brenna J. C.⋅Zhang, Yifan⋅Dietrich, Christopher⋅Gonzalez Gutierrez, Giovanni and Giedroc, David P.Cold Spring Harbor Laboratory
The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and recognizes diverse DNA sequencesNewman, J.D.⋅Russell, M.M.⋅Gonzalez Gutierrez, G. and Kessel, J.C.
2019
Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii. Cell chemical biologyWang, Jiefei⋅Wang, Jiefei⋅Lonergan, Zachery R⋅Lonergan, Zachery R⋅Gonzalez-Gutierrez, Giovanni⋅Gonzalez-Gutierrez, Giovanni⋅Nairn, Brittany L⋅Nairn, Brittany L⋅Maxwell, Christina N⋅Maxwell, Christina N⋅Zhang, Yixiang⋅Zhang, Yixiang⋅Andreini, Claudia⋅Andreini, Claudia⋅Karty, Jonathan A⋅Karty, Jonathan A⋅Chazin, Walter J⋅Chazin, Walter J⋅Trinidad, Jonathan C⋅Trinidad, Jonathan C⋅Skaar, Eric P⋅Skaar, Eric P⋅Giedroc, David P and Giedroc, David P.
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Structural differences between the Woodchuck hepatitis virus core protein in dimer and capsid states indicate entropic and conformational regulation of assemblyZhao, Z.⋅Wang, J.C.-Y.⋅Gonzalez Gutierrez, G. and Venkatakrishnan, B.
Structural Differences between the Woodchuck Hepatitis Virus Core Protein in the Dimer and Capsid States Are Consistent with Entropic and Conformational Regulation of Assembly. Journal of virologyZhao, Zhongchao⋅Wang, Joseph Che-Yen⋅Gonzalez-Gutierrez, Giovanni⋅Venkatakrishnan, Balasubramanian⋅Asor, Roi⋅Khaykelson, Daniel⋅Raviv, Uri and Zlotnick, Adam.
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2018
Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System.Capdevila, Daiana A⋅Capdevila, Daiana A⋅Capdevila, Daiana A⋅DA, Capdevila⋅Capdevila, Daiana A⋅Edmonds, Katherine A⋅Edmonds, Katherine A⋅Edmonds, Katherine A⋅KA, Edmonds⋅Edmonds, Katherine A⋅Campanello, Gregory C⋅Campanello, Gregory C⋅Campanello, Gregory C⋅GC, Campanello⋅Campanello, Gregory⋅Wu, Hongwei⋅Wu, Hongwei⋅Wu, Hongwei⋅Wu, Hongwei⋅H, Wu⋅Gonzalez-Gutierrez, Giovanni⋅Gonzalez-Gutierrez, Giovanni⋅G, Gonzalez Gutierrez⋅Gonzalez-Gutierrez, Giovanni⋅Gonzalez-Gutierrez, Giovanni⋅Giedroc, David P⋅Giedroc, David P⋅Giedroc, David P⋅DP, Giedroc and Giedroc, David PJournal of the American Chemical Society.
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Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell chemical biologyBum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Zhou, Donghui⋅Zhou, Donghui⋅Zhou, Donghui⋅Zhou, Donghui⋅Gonzalez-Gutierrez, Giovanni⋅Gonzalez-Gutierrez, Giovanni⋅Gonzalez-Gutierrez, Giovanni⋅Gonzalez-Gutierrez, Giovanni⋅Ghozayel, Mona K⋅Ghozayel, Mona K⋅Ghozayel, Mona K⋅Ghozayel, Mona K⋅Si, Yubing⋅Si, Yubing⋅Si, Yubing⋅Si, Yubing⋅Xu, David⋅Xu, David⋅Xu, David⋅Xu, David⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Corson, Timothy W⋅Corson, Timothy W⋅Corson, Timothy W⋅Corson, Timothy W⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Wells, Clark D⋅Wells, Clark D⋅Wells, Clark D⋅Wells, Clark D⋅Meroueh, Samy O⋅Meroueh, Samy O⋅Meroueh, Samy O and Meroueh, Samy O.
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2017
Chasing the open-state structure of pentameric ligand-gated ion channels.G, Gonzalez Gutierrez⋅Y, Wang⋅GD, Cymes⋅E, Tajkhorshid and C, GrosmanThe Journal of general physiology.
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2015
The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold.Gonzalez-Gutierrez, Giovanni⋅G, Gonzalez Gutierrez⋅C, Grosman and Grosman, ClaudioThe Journal of general physiology.
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2013
Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography.Gonzalez-Gutierrez, Giovanni⋅G, Gonzalez Gutierrez⋅LG, Cuello⋅Cuello, Luis G⋅Nair, Satish K⋅SK, Nair⋅Grosman, Claudio F and C, GrosmanProceedings of the National Academy of Sciences of the United States of America.
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