Research in the Hardy laboratory is focused on the molecular requirements for virus replication. We are specifically interested in what molecules are necessary for the replication of the viral genetic material and the optimal expression of viral genes within host cells.
Our research examines the viral and host requirements viral genome replication, gene expression, and transmission.
- Protein-genome interactions
- Particle composition and virus transmission
- Wolbachia, pathogen blocking and RNA modification
Another research area in the lab is the examination of the virus-arthropod host interaction.
- Eukaryotic Cell Biology, Cytoskeleton, and Signaling
An active are of research in the lab focuses on determining the molecular interactions required to form a functional genome replication complex.
- Virus-host interactions shaping alphavirus infection
- Molecular mechanisms of pathogen blocking
- Effect of RNA modifications on alphavirus infection
- Effect of the microbiome on vectorial capacity of mosquitoes.
Our group is broadly interested in understanding the molecular interactions between viruses and host cells that regulate virus replication, using arthropod-borne viruses i.e. arboviruses as our model.
- eukaryotic cell biology, cytoskeleton and signaling, virology, genome functions of RNA viruses and the roles of trans-acting factors
- Molecular Life Sciences