Current work in my laboratory is focused on developing small molecule inhibitors of these mechanisms and on defining the mechanisms of transformation by Hox proteins, which are deregulated in more than half of all myeloid acute leukemias.
My research over the past 20 years has focused on the mechanisms of Hox gene regulation by the mixed lineage leukemia protein, MLL, transcriptional deregulation by MLL fusion proteins, and the role of Hox genes in hematopoiesis and leukemia.
