38 Publications (Page 1 of 2)
2018
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Sun, YuqingZhou, BoMao, FengbiaoXu, JingMiao, HongzhiZou, ZhenhuaPhuc Khoa, Le TranJang, YounghoonCai, ShengWitkin, MatthewKoche, RichardGe, KaiDressler, Gregory RLevine, Ross LArmstrong, Scott ADou, Yali and Hess, Jay L
Cancer cell, September 19, 2018. | Journal Article
2016
Deregulation of the HOXA9/MEIS1 axis in acute leukemia
Collins, Cailin T and Hess, Jay L
Current opinion in hematology, vol. 23, (no. 4), pp. 361, 2016-07-00. | Journal Article
 
PRDM16 suppresses MLL leukemia via intrinsic histone methyltransferase activity
Zhou, BoZhou, BoWang, JingyaWang, JingyaLee, Shirley YLee, Shirley YXiong, JieXiong, JieBhanu, NatarajanBhanu, NatarajanGuo, QiGuo, QiMa, PeilinMa, PeilinSun, YuqingSun, YuqingRao, Rajesh CRao, Rajesh CGarcia, Benjamin AGarcia, Benjamin AHess, Jay LHess, Jay LDou, Yali and Dou, Yali
Molecular cell, vol. 62, (no. 2), pp. 236, 2016-04-14. | Journal Article
2014
Targeting MLL1 H3 K4 methyltransferase activity in MLL leukemia
Cao, FangCao, FangTownsend, Elizabeth CTownsend, Elizabeth CKaratas, HacerKaratas, HacerXu, JingXu, JingLi, LiLi, LiLee, ShirleyLee, ShirleyLiu, LiuLiu, LiuChen, YongChen, YongOuillette, PeterOuillette, PeterZhu, JidongZhu, JidongHess, JayHess, Jay LAtadja, PeterAtadja, PeterLei, MingLei, MingQin, Zhaohui SQin, ZhaohuiMalek, Sami NMalek, SamiWang, ShaomengWang, ShaomengDou, Yali and Dou, Yali
Molecular cell, vol. 53, (no. 2), pp. 261, 2014-01-02. | Journal Article
2013
MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction
Muntean, Andrew GMuntean, Andrew GChen, WeiChen, WeiJones, MorganJones, MorganGranowicz, Eric MGranowicz, Eric MMaillard, IvanMaillard, IvanHess, Jay and Hess, Jay L
Blood, vol. 122, (no. 11), pp. 1922, 2013-Sep-12. | Journal Article
 
Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins
Shen, ChenxiShen, ChenxiJo, Stephanie YJo, Stephanie YLiao, ChenzhongLiao, ChenzhongHess, Jay LHess, Jay LNikolovska Coleska, Zaneta and Nikolovska-Coleska, Zaneta
The Journal of biological chemistry, vol. 288, (no. 42), pp. 30596, 2013-Oct-18. | Journal Article
2012
A Subset of Mixed Lineage Leukemia Proteins Has Plant Homeodomain (PHD)-mediated E3 Ligase Activity
Wang, JingyaWang, JingyaMuntean, Andrew GMuntean, Andrew GWu, LauraWu, LauraHess, Jay and Hess, Jay L
The Journal of biological chemistry, vol. 287, (no. 52), pp. 43416, 2012-Dec-21. | Journal Article
 
Mechanisms of Transcriptional Regulation and Transformation by HOXA9
Hess, Jay LCollins, CailinBronstein, JoelSun, Yuqing and Nagaraja, Surya
Blood, vol. 120, (no. 21), pp. SCI-30, 2012-11-16. | Journal Article
 
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Grembecka, JolantaGrembecka, JolantaGrembecka, JolantaHe, ShihanHe, ShihanHe, ShihanShi, AibinShi, AibinShi, AibinPurohit, TruptaPurohit, TruptaPurohit, TruptaMuntean, Andrew GMuntean, Andrew GMuntean, Andrew GSorenson, Roderick JSorenson, Roderick JSorenson, Roderick JShowalter, Hollis DShowalter, Hollis DShowalter, Hollis HMurai, Marcelo JMurai, Marcelo JMurai, Marcelo JBelcher, Amalia MBelcher, Amalia MBelcher, Amalia MHartley, ThomasHartley, ThomasHartley, ThomasHess, Jay LHess, JayHess, Jay LCierpicki, TomaszCierpicki, Tomasz and Cierpicki, Tomasz
Nature chemical biology, vol. 8, (no. 3), pp. 284, 2012-Jan-29. | Journal Article
2011
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia
Monroe, Sara CMonroe, SaraJo, Stephanie YJo, StephanieSanders, Daniel SSanders, DanielBasrur, VenkateshaBasrur, VenkateshaElenitoba Johnson, KojoElenitoba-Johnson, KojoSlany, Robert KSlany, RobertHess, Jay and Hess, Jay
Experimental Hematology, vol. 39, (no. 1), pp. 86.e5, 2011. | Journal Article
 
MLL Fusion Protein Driven AML Is Selectively Inhibited by Targeted Disruption of the MLL-PAFc Interaction
Muntean, Andrew GGranowicz, Eric M and Hess, Jay L
Blood, vol. 118, (no. 21), pp. 56, 2011-11-18. | Journal Article
 
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
Jo, Stephanie YJo, Stephanie YGranowicz, Eric MGranowicz, Eric MMaillard, IvanMaillard, IvanThomas, DafyddThomas, DafyddHess, Jay and Hess, Jay L
Blood, vol. 117, (no. 18), pp. 4768, 2011-May-05. | Journal Article
 
Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia
Grembecka, JolantaHe, ShihanShi, AibinPurohit, TruptaMuntean, Andrew GLi, XiaoqinHartley, ThomasSun, DuxinHess, Jay L and Cierpicki, Tomasz
Blood, vol. 118, (no. 21), pp. 2497, 2011-11-18. | Journal Article
2010
The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis
Muntean, Andrew GMuntean, Andrew GTan, JiayingTan, JiayingSitwala, KajalSitwala, KajalHuang, YongshengHuang, YongshengBronstein, JoelBronstein, JoelConnelly, James AConnelly, James AlbertBasrur, VenkateshaBasrur, VenkateshaElenitoba Johnson, KojoElenitoba-Johnson, Kojo S.JHess, Jay and Hess, Jay L
Cancer Cell, vol. 17, (no. 6), pp. 621, 2010. | Journal Article
2009
MLL Associates with Telomeres and Regulates Telomeric Repeat-Containing RNA Transcription
Caslini, CorradoCaslini, CorradoConnelly, James AlbertConnelly, JamesSerna, AmparoSerna, AmparoBroccoli, DominiqueBroccoli, DominiqueHess, Jay and Hess, Jay
Molecular and Cellular Biology, vol. 29, (no. 16), pp. 4526, 20090815. | Journal Article
2008
Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia
Dou, YaliDou, YaliDou, YaliHess, JayHess, Jay and Hess, Jay
International Journal of Hematology, vol. 87, (no. 1), pp. 18, 20080100. | Journal Article
 
The PHD fingers of MLL block MLL fusion protein-mediated transformation
Muntean, Andrew GMuntean, Andrew GGiannola, DianeGiannola, DianeUdager, Aaron MUdager, Aaron MHess, Jay and Hess, Jay L
Blood, vol. 112, (no. 12), pp. 4693, 2008-Dec-01. | Journal Article
2007
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
Mueller, DorotheeMueller, DorotheeBach, ChristianBach, ChristianZeisig, DenizZeisig, DenizGarcia-Cuellar, Maria-PazGarcia-Cuellar, Maria-PazMonroe, SaraMonroe, SaraSreekumar, ArunSreekumar, ArunZhou, RongZhou, RongNesvizhskii, AlexeyNesvizhskii, Alexey IChinnaiyan, Arul MChinnaiyan, ArulHess, JayHess, Jay LSlany, Robert K and Slany, Robert K
Blood, vol. 110, (no. 13), pp. 4454, 2007-Dec-15. | Journal Article
 
Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation
Caslini, CorradoCaslini, CorradoYang, ZhaohaiYang, ZhaohaiEl-Osta, MohamadEl-Osta, MohamadMilne, Thomas AMilne, ThomasSlany, Robert KSlany, RobertHess, Jay and Hess, Jay
Cancer Research, vol. 67, (no. 15), pp. 7283, 20070801. | Journal Article
 
The MLL PHD Fingers of MLL Block MLL Fusion Protein Mediated Transformation
Muntean, Andrew G and Hess, Jay L
Blood, vol. 110, (no. 11), pp. 976, 2007-11-16. | Journal Article
2006
Purification of an MLL Partner Associated Complex (MPAC) Suggests a Common Role for MLL Fusion Partners in Transcriptional Elongation
Slany, Robert KMueller, DorotheeBach, ChristianZeisig, DenizGarcia-Cuellar, Maria-PazMonroe, SaraSreekumar, ArunZhao, RonNesvizhskii, AlexeyChinnaiyan, Arul and Hess, Jay L
Blood, vol. 108, (no. 11), pp. 770, 2006-11-16. | Journal Article
 
The Tumor Suppressor Menin Regulates Hematopoiesis and Myeloid Transformation by Influencing Hox Gene Expression
Chen, Ya-XiongChen, Ya-XiongYan, JizhouYan, JizhouKeeshan, KarenKeeshan, KarenTubbs, Anthony TTubbs, AnthonyWang, HaorenWang, HaorenSilva, AlbertSilva, AlbertBrown, EricBrown, Eric JHess, JayHess, JayPear, Warren SPear, WarrenHua, Xianxin and Hua, Xianxin
Proceedings of the National Academy of Sciences of the United States of America, vol. 103, (no. 4), pp. 1023, 20060124. | Journal Article
2005
Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation
Hess, Jay LYang, ZhaohaiWang, HaorenChen, Ya-XiongMilne, Thomas AMartin, Mary EllenSlany, Robert K and Hua, Xianxin
Blood, vol. 106, (no. 11), pp. 664, 2005-11-16. | Journal Article
 
Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications
Milne, Thomas AMilne, ThomasMartin, Mary EMartin, MaryBrock, Hugh WBrock, HughSlany, RobertSlany, Robert KHess, Jay and Hess, Jay
Cancer Research, vol. 65, (no. 24), pp. 11367, 20051215. | Journal Article
 
Menin and MLL Cooperatively Regulate Expression of Cyclin-Dependent Kinase Inhibitors
Milne, Thomas AMilne, ThomasHughes, ChristinaHughes, Christina MLloyd, RicardoLloyd, RicardoYang, ZhaohaiYang, ZhaohaiRozenblatt-Rosen, OritRozenblatt-Rosen, OritDou, YaliDou, YaliSchnepp, Robert WSchnepp, RobertKrankel, CynthiaKrankel, CynthiaLi Volsi, Virginia ALiVolsi, VirginiaGibbs, DeniseGibbs, DeniseHua, XianxinHua, XianxinRoeder, Robert GRoeder, RobertMeyerson, MatthewMeyerson, Matthew LHess, Jay and Hess, Jay
Proceedings of the National Academy of Sciences of the United States of America, vol. 102, (no. 3), pp. 754, 20050118. | Journal Article