44 Publications (Page 1 of 2)
2018
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Sun, Yuqing⋅Zhou, Bo⋅Mao, Fengbiao⋅Xu, Jing⋅Miao, Hongzhi⋅Zou, Zhenhua⋅Phuc Khoa, Le Tran⋅Jang, Younghoon⋅Cai, Sheng⋅Witkin, Matthew⋅Koche, Richard⋅Ge, Kai⋅Dressler, Gregory R⋅Levine, Ross L⋅Armstrong, Scott A⋅Dou, Yali and Hess, Jay L
Cancer cell, September 19, 2018. | Journal Article
2017
A new target for differentiation therapy in AML
Ma, Peilin⋅Song, Weihua and Hess, Jay L
Cell Research, vol. 27, (no. 1), pp. 9-10, Jan 2017. | Journal Article
2016
Deregulation of the HOXA9/MEIS1 axis in acute leukemia
Collins, Cailin T and Hess, Jay L
Current opinion in hematology, vol. 23, (no. 4), pp. 361, 2016-07-00. | Journal Article
 
PRDM16 suppresses MLL leukemia via intrinsic histone methyltransferase activity
Zhou, Bo⋅Zhou, Bo⋅Wang, Jingya⋅Wang, Jingya⋅Lee, Shirley Y⋅Lee, Shirley Y⋅Xiong, Jie⋅Xiong, Jie⋅Bhanu, Natarajan⋅Bhanu, Natarajan⋅Guo, Qi⋅Guo, Qi⋅Ma, Peilin⋅Ma, Peilin⋅Sun, Yuqing⋅Sun, Yuqing⋅Rao, Rajesh C⋅Rao, Rajesh C⋅Garcia, Benjamin A⋅Garcia, Benjamin A⋅Hess, Jay L⋅Hess, Jay L⋅Dou, Yali and Dou, Yali
Molecular cell, vol. 62, (no. 2), pp. 236, 2016-04-14. | Journal Article
2014
Targeting MLL1 H3 K4 methyltransferase activity in MLL leukemia
Cao, Fang⋅Cao, Fang⋅Cao, Fang⋅Townsend, Elizabeth C⋅Townsend, Elizabeth C.⋅Townsend, Elizabeth C⋅Karatas, Hacer⋅Karatas, Hacer⋅Karatas, Hacer⋅Xu, Jing⋅Xu, Jing⋅Xu, Jing⋅Li, Li⋅Li, Li⋅Li, Li⋅Lee, Shirley⋅Lee, Shirley⋅Lee, Shirley⋅Liu, Liu⋅Liu, Liu⋅Liu, Liu⋅Chen, Yong⋅Chen, Yong⋅Chen, Yong⋅Ouillette, Peter⋅Ouillette, Peter⋅Ouillette, Peter⋅Zhu, Jidong⋅Zhu, Jidong⋅Zhu, Jidong⋅Hess, Jay L.⋅Hess, Jay⋅Hess, Jay L⋅Atadja, Peter⋅Atadja, Peter⋅Atadja, Peter⋅Lei, Ming⋅Lei, Ming⋅Lei, Ming⋅Qin, Zhaohui⋅Qin, Zhaohui S⋅Qin, Zhaohui S.⋅Malek, Sami⋅Malek, Sami⋅Malek, Sami N⋅Wang, Shaomeng⋅Wang, Shaomeng⋅Wang, Shaomeng⋅Dou, Yali⋅Dou, Yali and Dou, Yali
Molecular cell, vol. 53, (no. 2), pp. 261, 2014-01-02. | Journal Article
2013
MLL fusion protein-driven AML is selectively inhibited by targeted disruption of the MLL-PAFc interaction
Muntean, Andrew G⋅Muntean, Andrew G⋅Chen, Wei⋅Chen, Wei⋅Jones, Morgan⋅Jones, Morgan⋅Granowicz, Eric M⋅Granowicz, Eric M⋅Maillard, Ivan⋅Maillard, Ivan⋅Hess, Jay and Hess, Jay L
Blood, vol. 122, (no. 11), pp. 1922, 2013-Sep-12. | Journal Article
 
Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins
Shen, Chenxi⋅Shen, Chenxi⋅Jo, Stephanie Y⋅Jo, Stephanie Y⋅Liao, Chenzhong⋅Liao, Chenzhong⋅Hess, Jay L⋅Hess, Jay L⋅Nikolovska Coleska, Zaneta and Nikolovska-Coleska, Zaneta
The Journal of biological chemistry, vol. 288, (no. 42), pp. 30596, 2013-Oct-18. | Journal Article
2012
A Subset of Mixed Lineage Leukemia Proteins Has Plant Homeodomain (PHD)-mediated E3 Ligase Activity
Wang, Jingya⋅Wang, Jingya⋅Muntean, Andrew G⋅Muntean, Andrew G⋅Wu, Laura⋅Wu, Laura⋅Hess, Jay and Hess, Jay L
The Journal of biological chemistry, vol. 287, (no. 52), pp. 43416, 2012-Dec-21. | Journal Article
 
Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia
Akalin, Altuna⋅Akalin, A.⋅Akalin, Altuna⋅Garrett-Bakelman, Francine E⋅Garrett-Bakelman, Francine E⋅Garrett-Bakelman, F.E.⋅Kormaksson, Matthias⋅Kormaksson, Matthias⋅Kormaksson, M.⋅Busuttil, J.⋅Busuttil, Jennifer⋅Busuttil, Jennifer⋅Zhang, Lu⋅Zhang, Lu⋅Zhang, L.⋅Khrebtukova, Irina⋅Khrebtukova, Irina⋅Khrebtukova, I.⋅Milne, Thomas A⋅Milne, Thomas A⋅Milne, T.A.⋅Huang, Y.⋅Huang, Yongsheng⋅Huang, Yongsheng⋅Biswas, D.⋅Biswas, Debabrata⋅Biswas, Debabrata⋅Hess, J.L.⋅Hess, Jay⋅Hess, Jay L⋅Allis, C.D.⋅Allis, C D⋅Allis, C. D⋅Roeder, Robert G⋅Roeder, R.G.⋅Roeder, Robert G⋅Valk, Peter J⋅Valk, Peter J⋅Valk, P.J.M.⋅Löwenberg, Bob⋅Löwenberg, B.⋅Löwenberg, Bob⋅Delwel, Ruud⋅Delwel, Ruud⋅Delwel, R.⋅Fernandez, Hugo F⋅Fernandez, Hugo F⋅Fernandez, H.F.⋅Paietta, Elisabeth⋅Paietta, E.⋅Paietta, Elisabeth M⋅Tallman, Martin S⋅Tallman, Martin S⋅Tallman, M.S.⋅Schroth, Gary P⋅Schroth, Gary P⋅Schroth, G.P.⋅Mason, C.E.⋅Mason, Christopher E⋅Mason, Christopher⋅Melnick, Ari M⋅Melnick, A.⋅Melnick, Ari⋅Figueroa, Maria E⋅Figueroa, Maria E and Figueroa, M.E.
PLoS Genetics, vol. 8, (no. 6), Jun 2012. | Journal Article
 
Mechanisms of Transcriptional Regulation and Transformation by HOXA9
Hess, Jay L⋅Collins, Cailin⋅Bronstein, Joel⋅Sun, Yuqing and Nagaraja, Surya
Blood, vol. 120, (no. 21), pp. SCI-30, 2012-11-16. | Journal Article
 
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Grembecka, Jolanta⋅Grembecka, Jolanta⋅Grembecka, Jolanta⋅He, Shihan⋅He, Shihan⋅He, Shihan⋅Shi, Aibin⋅Shi, Aibin⋅Shi, Aibin⋅Purohit, Trupta⋅Purohit, Trupta⋅Purohit, Trupta⋅Muntean, Andrew G⋅Muntean, Andrew G⋅Muntean, Andrew G⋅Sorenson, Roderick J⋅Sorenson, Roderick J⋅Sorenson, Roderick J⋅Showalter, Hollis D⋅Showalter, Hollis H⋅Showalter, Hollis D⋅Murai, Marcelo J⋅Murai, Marcelo J⋅Murai, Marcelo J⋅Belcher, Amalia M⋅Belcher, Amalia M⋅Belcher, Amalia M⋅Hartley, Thomas⋅Hartley, Thomas⋅Hartley, Thomas⋅Hess, Jay L⋅Hess, Jay L⋅Hess, Jay⋅Cierpicki, Tomasz⋅Cierpicki, Tomasz and Cierpicki, Tomasz
Nature chemical biology, vol. 8, (no. 3), pp. 284, 2012-Jan-29. | Journal Article
2011
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia
Monroe, Sara C⋅Monroe, Sara⋅Jo, Stephanie Y⋅Jo, Stephanie⋅Sanders, Daniel S⋅Sanders, Daniel⋅Basrur, Venkatesha⋅Basrur, Venkatesha⋅Elenitoba Johnson, Kojo⋅Elenitoba-Johnson, Kojo⋅Slany, Robert K⋅Slany, Robert⋅Hess, Jay and Hess, Jay
Experimental Hematology, vol. 39, (no. 1), pp. 86.e5, 2011. | Journal Article
 
MLL Fusion Protein Driven AML Is Selectively Inhibited by Targeted Disruption of the MLL-PAFc Interaction
Muntean, Andrew G⋅Granowicz, Eric M and Hess, Jay L
Blood, vol. 118, (no. 21), pp. 56, 2011-11-18. | Journal Article
 
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
Jo, Stephanie Y⋅Jo, Stephanie Y⋅Granowicz, Eric M⋅Granowicz, Eric M⋅Maillard, Ivan⋅Maillard, Ivan⋅Thomas, Dafydd⋅Thomas, Dafydd⋅Hess, Jay and Hess, Jay L
Blood, vol. 117, (no. 18), pp. 4768, 2011-May-05. | Journal Article
 
Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia
Grembecka, Jolanta⋅He, Shihan⋅Shi, Aibin⋅Purohit, Trupta⋅Muntean, Andrew G⋅Li, Xiaoqin⋅Hartley, Thomas⋅Sun, Duxin⋅Hess, Jay L and Cierpicki, Tomasz
Blood, vol. 118, (no. 21), pp. 2497, 2011-11-18. | Journal Article
2010
The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis
Muntean, Andrew G⋅Muntean, Andrew G⋅Tan, Jiaying⋅Tan, Jiaying⋅Sitwala, Kajal⋅Sitwala, Kajal⋅Huang, Yongsheng⋅Huang, Yongsheng⋅Bronstein, Joel⋅Bronstein, Joel⋅Connelly, James Albert⋅Connelly, James A⋅Basrur, Venkatesha⋅Basrur, Venkatesha⋅Elenitoba-Johnson, Kojo S.J⋅Elenitoba Johnson, Kojo⋅Hess, Jay and Hess, Jay L
Cancer Cell, vol. 17, (no. 6), pp. 621, 2010. | Journal Article
2009
MLL Associates with Telomeres and Regulates Telomeric Repeat-Containing RNA Transcription
Caslini, Corrado⋅Caslini, Corrado⋅Connelly, James Albert⋅Connelly, James⋅Serna, Amparo⋅Serna, Amparo⋅Broccoli, Dominique⋅Broccoli, Dominique⋅Hess, Jay and Hess, Jay
Molecular and Cellular Biology, vol. 29, (no. 16), pp. 4526, 20090815. | Journal Article
 
What Hematopathology Tells Us About the Future of Pathology Informatics
Hess, Jay L and Hess, Jay
Archives of Pathology & Laboratory Medicine, vol. 133, (no. 6), pp. 908-11, Jun 2009. | Journal Article
2008
Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia
Dou, Yali⋅Dou, Yali⋅Dou, Yali⋅Hess, Jay⋅Hess, Jay and Hess, Jay
International Journal of Hematology, vol. 87, (no. 1), pp. 18, 20080100. | Journal Article
 
The PHD fingers of MLL block MLL fusion protein-mediated transformation
Muntean, Andrew G⋅Muntean, Andrew G⋅Giannola, Diane⋅Giannola, Diane⋅Udager, Aaron M⋅Udager, Aaron M⋅Hess, Jay and Hess, Jay L
Blood, vol. 112, (no. 12), pp. 4693, 2008-Dec-01. | Journal Article
2007
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification
Mueller, Dorothee⋅Mueller, Dorothee⋅Bach, Christian⋅Bach, Christian⋅Zeisig, Deniz⋅Zeisig, Deniz⋅Garcia-Cuellar, Maria-Paz⋅Garcia-Cuellar, Maria-Paz⋅Monroe, Sara⋅Monroe, Sara⋅Sreekumar, Arun⋅Sreekumar, Arun⋅Zhou, Rong⋅Zhou, Rong⋅Nesvizhskii, Alexey⋅Nesvizhskii, Alexey I⋅Chinnaiyan, Arul M⋅Chinnaiyan, Arul⋅Hess, Jay⋅Hess, Jay L⋅Slany, Robert K and Slany, Robert K
Blood, vol. 110, (no. 13), pp. 4454, 2007-Dec-15. | Journal Article
 
Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation
Caslini, Corrado⋅Caslini, Corrado⋅Yang, Zhaohai⋅Yang, Zhaohai⋅El-Osta, Mohamad⋅El-Osta, Mohamad⋅Milne, Thomas A⋅Milne, Thomas⋅Slany, Robert K⋅Slany, Robert⋅Hess, Jay and Hess, Jay
Cancer Research, vol. 67, (no. 15), pp. 7283, 20070801. | Journal Article
 
The MLL PHD Fingers of MLL Block MLL Fusion Protein Mediated Transformation
Muntean, Andrew G and Hess, Jay L
Blood, vol. 110, (no. 11), pp. 976, 2007-11-16. | Journal Article
2006
Purification of an MLL Partner Associated Complex (MPAC) Suggests a Common Role for MLL Fusion Partners in Transcriptional Elongation
Slany, Robert K⋅Mueller, Dorothee⋅Bach, Christian⋅Zeisig, Deniz⋅Garcia-Cuellar, Maria-Paz⋅Monroe, Sara⋅Sreekumar, Arun⋅Zhao, Ron⋅Nesvizhskii, Alexey⋅Chinnaiyan, Arul and Hess, Jay L
Blood, vol. 108, (no. 11), pp. 770, 2006-11-16. | Journal Article
 
The Tumor Suppressor Menin Regulates Hematopoiesis and Myeloid Transformation by Influencing Hox Gene Expression
Chen, Ya-Xiong⋅Chen, Ya-Xiong⋅Yan, Jizhou⋅Yan, Jizhou⋅Keeshan, Karen⋅Keeshan, Karen⋅Tubbs, Anthony T⋅Tubbs, Anthony⋅Wang, Haoren⋅Wang, Haoren⋅Silva, Albert⋅Silva, Albert⋅Brown, Eric J⋅Brown, Eric⋅Hess, Jay⋅Hess, Jay⋅Pear, Warren⋅Pear, Warren S⋅Hua, Xianxin and Hua, Xianxin
Proceedings of the National Academy of Sciences of the United States of America, vol. 103, (no. 4), pp. 1023, 20060124. | Journal Article