Research in the Linnemann lab is focused on diabetes; specifically the study of the insulin producing pancreatic beta-cells under conditions of inflammatory stress.

Thus, we are particularly interested in how higher level metabolic signals contribute to molecular crosstalk within the islet and influence beta-cell adaptation to stress. In an effort to develop therapies that prevent beta-cell failure in type 1 and type 2 diabetes, projects in the lab are focused on 3 major areas:

  1. Identifying mechanisms of adaptive stress response in the pancreatic islet that enable beta-cell survival
  2. Studying paracrine signaling in the islet under conditions of stress and increased demand
  3. Understanding the regulation of core mediators of autophagy and how this process contributes to beta-cell homeostasis and survivial

Research: Islet Function and Survival

Endocrinology, Pediatrics, Pediatrics
PhD, Wayne State University, Molecular Biology, Genetics, 2009
BS, University of Detroit Mercy, 2002