15 Publications
2018
Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins
Mukherjee, Somnath⋅Griffin, Dionne H⋅Horn, James R⋅Rizk, Shahir S⋅Nocula-Lugowska, Malgorzata⋅Malmqvist, Magnus⋅Kim, Sangwoo S and Kossiakoff, Anthony A
The Journal of biological chemistry, vol. 293, (no. 8), pp. 2815, 2018-02-23. | Journal Article
2017
Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody
Rizk, Shahir⋅Rizk, Shahir S⋅Mukherjee, Somnath⋅Mukherjee, Somnath⋅Koide, Akiko⋅Koide, Akiko⋅Koide, Shohei⋅Koide, Shohei⋅Kossiakoff, Anthony A and Kossiakoff, Anthony
Scientific reports, vol. 7, (no. 1), pp. 6, 2017-04-03. | Journal Article
2015
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
Mbengue, Alassane⋅Mbengue, Alassane⋅Mbengue, Alassane⋅Mbengue, Alassane⋅Bhattacharjee, Souvik⋅Bhattacharjee, Souvik⋅Bhattacharjee, Souvik⋅Bhattacharjee, Souvik⋅Pandharkar, Trupti⋅Pandharkar, Trupti⋅Pandharkar, Trupti⋅Pandharkar, Trupti⋅Liu, Haining⋅Liu, Haining⋅Liu, Haining⋅Liu, Haining⋅Estiu, Guillermina⋅Estiu, Guillermina⋅Estiu, Guillermina⋅Estiu, Guillermina⋅Stahelin, Robert V⋅Stahelin, Robert V⋅Stahelin, Robert V⋅Stahelin, Robert V⋅Rizk, Shahir S⋅Rizk, Shahir S⋅Rizk, Shahir S⋅Rizk, Shahir S⋅Njimoh, Dieudonne L⋅Njimoh, Dieudonne L⋅Njimoh, Dieudonne L⋅Njimoh, Dieudonne L⋅Ryan, Yana⋅Ryan, Yana⋅Ryan, Yana⋅Ryan, Yana⋅Chotivanich, Kesinee⋅Chotivanich, Kesinee⋅Chotivanich, Kesinee⋅Chotivanich, Kesinee⋅Nguon, Chea⋅Nguon, Chea⋅Nguon, Chea⋅Nguon, Chea⋅Ghorbal, Mehdi⋅Ghorbal, Mehdi⋅Ghorbal, Mehdi⋅Ghorbal, Mehdi⋅Lopez-Rubio, Jose-Juan⋅Lopez-Rubio, Jose-Juan⋅Lopez-Rubio, Jose-Juan⋅Lopez-Rubio, Jose-Juan⋅Pfrender, Michael⋅Pfrender, Michael⋅Pfrender, Michael⋅Pfrender, Michael⋅Emrich, Scott⋅Emrich, Scott⋅Emrich, Scott⋅Emrich, Scott⋅Mohandas, Narla⋅Mohandas, Narla⋅Mohandas, Narla⋅Mohandas, Narla⋅Dondorp, Arjen M⋅Dondorp, Arjen M⋅Dondorp, Arjen M⋅Dondorp, Arjen M⋅Wiest, Olaf⋅Wiest, Olaf⋅Wiest, Olaf⋅Wiest, Olaf⋅Haldar, Kasturi⋅Haldar, Kasturi⋅Haldar, Kasturi and Haldar, Kasturi
Nature, vol. 520, (no. 7549), pp. 687, 2015-Apr-30. | Journal Article
 
Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling
Rizk, Shahir S⋅Rizk, Shahir S⋅Kouadio, Jean-Louis K⋅Kouadio, Jean-Louis K⋅Szymborska, Anna⋅Szymborska, Anna⋅Duguid, Erica M⋅Duguid, Erica M⋅Mukherjee, Somnath⋅Mukherjee, Somnath⋅Zheng, Jiamao⋅Zheng, Jiamao⋅Clevenger, Charles V⋅Clevenger, Charles V⋅Kossiakoff, Anthony A and Kossiakoff, Anthony A
Cell communication and signaling : CCS, vol. 13, (no. 1), pp. 1, 2015-Jan-15. | Journal Article
2013
Generating conformation-specific synthetic antibodies to trap proteins in selected functional states
Paduch, Marcin⋅Paduch, Marcin⋅Koide, Akiko⋅Koide, Akiko⋅Uysal, Serdar⋅Uysal, Serdar⋅Rizk, Shahir S⋅Rizk, Shahir S⋅Koide, Shohei⋅Koide, Shohei⋅Kossiakoff, Anthony A and Kossiakoff, Anthony A
Methods, vol. 60, (no. 1), pp. 14, 2013-03-15. | Journal Article
2012
Substance P Derivatives as Versatile Tools for Specific Delivery of Various Types of Biomolecular Cargo
Rizk, Shahir S⋅Rizk, Shahir S⋅Misiura, Agnieszka⋅Misiura, Agnieszka⋅Paduch, Marcin⋅Paduch, Marcin⋅Kossiakoff, Anthony A and Kossiakoff, Anthony A
Bioconjugate Chemistry, vol. 23, (no. 1), pp. 46, 20120118. | Journal Article
2011
Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins
Rizk, Shahir S⋅Sandstrom, Andrew⋅Kossiakoff, Anthony A⋅Heithaus, John H⋅Duguid, Erica M⋅Paduch, Marcin⋅Rizk, Shahir S⋅Rizk, Shahir S⋅Paduch, Marcin⋅Paduch, Marcin⋅Heithaus, John H⋅Heithaus, John H⋅Duguid, Erica M⋅Duguid, Erica M⋅Sandstrom, Andrew⋅Sandstrom, Andrew⋅Kossiakoff, Anthony A and Kossiakoff, Anthony A
Nature Structural & Molecular Biology, vol. 18, (no. 4), pp. 442, 201104. | Journal Article
2010
Generation of a De Novo Actin Pointed-End Binding Protein
Brawley, Crista M⋅Uysal, Serdar⋅Rizk, Shahir⋅Luchniak, Anna⋅Kossiakoff, Anthony and Rock, Ronald S
Biophysical Journal, vol. 98, (no. 3), pp. 157, 2010-01-00. | Journal Article
 
Keeping Signaling in Check
Kossiakoff, Anthony⋅Kossiakoff, Anthony A⋅Rizk, Shahir and Rizk, Shahir
Structure, vol. 18, (no. 3), pp. 276, 2010. | Journal Article
 
Molecular Modeling and Simulations of the Transmembrane Domain of Human Growth Hormone Receptor
Kumar, Ritesh⋅Rizk, Shahir S⋅Kossiakoff, Anthony A and Im, Wonpil
Biophysical Journal, vol. 98, (no. 3), pp. 417, 2010-01-00. | Journal Article
2009
An Engineered Substance P Variant for Receptor-Mediated Delivery of Synthetic Antibodies into Tumor Cells
Rizk, Shahir S⋅Rizk, Shahir⋅Luchniak, Anna⋅Luchniak, Anna⋅Uysal, Serdar⋅Uysal, Serdar⋅Brawley, Crista⋅Brawley, Crista M⋅Rock, Ronald S⋅Rock, Ronald⋅Kossiakoff, Anthony⋅Kossiakoff, Anthony A and Wells, James
Proceedings of the National Academy of Sciences of the United States of America, vol. 106, (no. 27), pp. 11015, 20090707. | Journal Article
2006
Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates
Rizk, Shahir S⋅Rizk, Shahir S⋅Cuneo, Matthew J⋅Cuneo, Matthew J⋅Hellinga, Homme W and Hellinga, Homme W
Protein Science, vol. 15, (no. 7), pp. 1751, July 2006. | Journal Article
2004
Computational Design of Receptors for an Organophosphate Surrogate of the Nerve Agent Soman
Allert, Malin⋅Allert, Malin⋅Rizk, Shahir⋅Rizk, Shahir S⋅Looger, Loren L⋅Looger, Loren⋅Hellinga, Homme⋅Hellinga, Homme W and Wells, James
Proceedings of the National Academy of Sciences of the United States of America, vol. 101, (no. 21), pp. 7912, 20040525. | Journal Article
2002
Construction of a fluorescent biosensor family
de Lorimier, Robert M⋅De Lorimier, Robert M⋅Smith, J J⋅Smith, J. Jeff⋅Dwyer, Mary A⋅Dwyer, Mary A⋅Looger, Loren L⋅Looger, Loren L⋅Sali, Kevin M⋅Sali, Kevin M⋅Paavola, Chad D⋅Paavola, Chad D⋅Rizk, Shahir S⋅Rizk, Shahir S⋅Sadigov, Shamil⋅Sadigov, Shamil⋅Conrad, David W⋅Conrad, David W⋅Loew, Leslie M⋅Loew, Leslie⋅Hellinga, Homme W and Hellinga, Homme W
Protein Science, vol. 11, (no. 11), pp. 2675, November 2002. | Journal Article
 
Control of a biomolecular motor-powered nanodevice with an engineered chemical switch
Liu, H.⋅Schmidt, Jacob J⋅Montemagno, Carlo D⋅Hellinga, Homme W⋅Liu, Haiqing⋅Looger, Loren L⋅Rizk, Shahir S⋅Bachand, George D⋅Liu, Haiqing⋅Schmidt, Jacob J⋅Schmidt, Jacob J⋅Bachand, G. D⋅Bachand, George D⋅Rizk, Shahir S⋅Rizk, S. S⋅Looger, L. L⋅Looger, Loren L⋅Hellinga, Homme W⋅Hellinga, Homme W⋅Montemagno, Carlo D and Montemagno, Carlo D
Nature Materials, vol. 1, (no. 3), pp. 177, 200211. | Journal Article