203 Publications (Page 3 of 9)
2012
Abstract 1769: Significant in vivo activity of an APE1/Ref-1 redox inhibitor, E3330, alone and in combination with Bevacizumab in a glioblastoma mouse model analyzed by a whole slide digital imaging system and quantitative immunohistochemistry
Kumar, Krishan⋅Kumar, Krishan⋅Jackson, Jessica L⋅Jackson, Jessica L⋅Kelley, Mark R⋅Kelley, Mark R⋅Ivan, Mircea⋅Ivan, Mircea⋅Sandsuky, George and Sandsuky, George
Cancer Research, vol. 72, (no. 8 Supplement), pp. 1769, 2012-04-15. | Journal Article
 
APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.
Cardoso, Angelo A⋅Cardoso, Angelo A⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Luo, Meihua⋅Luo, Meihua⋅Reed, April M⋅Reed, April M⋅Shahda, Safi⋅Shahda, Safi⋅He, Ying⋅He, Ying⋅Maitra, Anirban⋅Maitra, Anirban⋅Kelley, Mark⋅Kelley, Mark R⋅Fishel, Melissa L and Fishel, Melissa L
PloS one, vol. 7, (no. 10), pp. e47462, 2012. | Journal Article
 
APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.
Kelley, Mark⋅Kelley, Mark R⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Fishel, Melissa L and Fishel, Melissa L
Current molecular pharmacology, vol. 5, (no. 1), pp. 36-53, 2012/Jan. | Journal Article
 
APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1
Kelley, Mark⋅Kelley, Mark⋅Kelley, Mark⋅Georgiadis, Millie⋅Georgiadis, Millie⋅Georgiadis, Millie⋅Fishel, Melissa⋅Fishel, Melissa and Fishel, Melissa
Current Molecular Pharmacology, vol. 5, (no. 1), pp. 53, 2012-January. | Journal Article
 
Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.
Luo, Meihua⋅Zhang, Jun⋅He, Hongzhen⋅Su, Dian⋅Chen, Qiujia⋅Gross, Michael L⋅Kelley, Mark and Georgiadis, Millie M
Biochemistry, vol. 51, (no. 2), pp. 695-705, 2012/Jan/17. | Journal Article
2011
Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages.
Jedinak, Andrej⋅Dudhgaonkar, Shailesh⋅Kelley, Mark R and Sliva, Daniel
Anticancer research, vol. 31, (no. 2), pp. 379-385, February 2011. | Journal Article
 
Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii
Onyango, David O⋅Naguleswaran, Arunasalam⋅Delaplane, Sarah⋅Reed, April⋅Kelley, Mark R⋅Georgiadis, Millie M and Sullivan, William J
DNA Repair, vol. 10, (no. 5), pp. 466-475, 2011. | Journal Article
 
DNA repair inhibitors: where do we go from here?
Kelley, Mark
DNA repair, vol. 10, (no. 11), pp. 1183-5, 2011/Nov/10. | Journal Article
 
Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1
Kelley, Mark R⋅Luo, M.⋅Reed, A.⋅Su, D.⋅Delaplane, S.⋅Borch, Rich F⋅Nyland, RL I⋅Gross, Michael L and Georgiadis, Millie M
Antioxidants and Redox Signaling, vol. 14, (no. 8), pp. 1387-1401, 2011. | Journal Article
 
Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth.
Fishel, Melissa L⋅Fishel, Melissa L⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Rajeshkumar, N V⋅Rajeshkumar, N V⋅Scandura, Glenda⋅Scandura, Glenda⋅Sinn, Anthony L⋅Sinn, Anthony L⋅He, Ying⋅He, Ying⋅Shen, Changyu⋅Shen, Changyu⋅Jones, David R⋅Jones, David R⋅Pollok, Karen E⋅Pollok, Karen E⋅Ivan, Mircea⋅Ivan, Mircea⋅Maitra, Anirban⋅Maitra, Anirban⋅Kelley, Mark R and Kelley, Mark
Molecular cancer therapeutics, vol. 10, (no. 9), pp. 1698-708, 2011/Sep. | Journal Article
 
Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo.
Jiang, Aihua⋅Gao, Hua⋅Kelley, Mark R and Qiao, Xiaoxi
Vision research, vol. 51, (no. 1), pp. 93-100, January 2011. | Journal Article
 
Interactions of apurinic/apyrimidinic endonuclease with aoxidative half-reaction : evidence for an alternate conformation of the enzyme
Su, Dian⋅Su, Dian⋅Vu, Bich⋅Vu, Bich⋅Kelley, Mark⋅Kelley, Mark⋅Gross, Michael⋅Gross, Michael⋅Georgiadis, Millie⋅Georgiadis, Millie⋅Delaplane, Sarah⋅Delaplane, Sarah⋅Luo, Meihua⋅Luo, Meihua⋅Rempel, Don and Rempel, Don
Biochemistry, vol. 50, (no. 1), pp. 82, 20110111. | Journal Article
 
Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme.
Su, Dian⋅Delaplane, Sarah⋅Luo, Meihua⋅Rempel, Don L⋅Vu, Bich⋅Kelley, Mark⋅Gross, Michael L and Georgiadis, Millie M
Biochemistry, vol. 50, (no. 1), pp. 82-92, 2011/Jan/11. | Journal Article
 
Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.
Vascotto, Carlo⋅Vascotto, Carlo⋅Bisetto, Elena⋅Bisetto, Elena⋅Li, Mengxia⋅Li, Mengxia⋅Zeef, Leo A⋅Zeef, Leo A H⋅D'Ambrosio, Chiara⋅D'Ambrosio, Chiara⋅Domenis, Rossana⋅Domenis, Rossana⋅Comelli, Marina⋅Comelli, Marina⋅Delneri, Daniela⋅Delneri, Daniela⋅Scaloni, Andrea⋅Scaloni, Andrea⋅Altieri, Fabio⋅Altieri, Fabio⋅Mavelli, Irene⋅Mavelli, Irene⋅Quadrifoglio, Franco⋅Quadrifoglio, Franco⋅Kelley, Mark R⋅Kelley, Mark⋅Tell, Gianluca and Tell, Gianluca
Molecular biology of the cell, vol. 22, (no. 20), pp. 3887-901, 2011/Oct. | Journal Article
 
Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro.
Rohrabaugh, Sara L⋅Hangoc, Giao⋅Kelley, Mark R and Broxmeyer, Hal E
Experimental hematology, vol. 39, (no. 4), pp. 415-23, 2011/Apr. | Journal Article
 
The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation.
Vasko, Michael R⋅Guo, Chunlu⋅Thompson, Eric L and Kelley, Mark
DNA repair, vol. 10, (no. 9), pp. 942-52, 2011/Sep/5. | Journal Article
 
Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel.
Gracias, N G⋅Cummins, T R⋅Kelley, Mark⋅Basile, David P⋅Iqbal, T and Vasko, Michael R
Neurotoxicology, vol. 32, (no. 1), pp. 140-9, 2011/Jan. | Journal Article
2010
Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells
Bapat, Aditi⋅Bapat, Aditi⋅Bapat, Aditi⋅Bapat, Aditi⋅Glass, LaTeca S⋅Glass, LaTeca S⋅Glass, LaTeca S⋅Glass, LaTeca S⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Reed, April⋅Reed, April⋅Reed, April⋅Reed, April⋅Long, Eric C⋅Long, Eric C⋅Long, Eric C⋅Long, Eric C⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R and Kelley, Mark R
Cancer Research, vol. 70, (no. 8 Supplement), pp. 1963, 2010-04-15. | Journal Article
 
Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1).
Nyland, Rodney L⋅Luo, Meihua⋅Kelley, Mark and Borch, Rich F
Journal of medicinal chemistry, vol. 53, (no. 3), pp. 1200-10, 2010/Feb/11. | Journal Article
 
Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis.
Fishel, Melissa L⋅Fishel, Melissa⋅Colvin, E.⋅Colvin, E S⋅Luo, Meihua⋅Luo, Meihua⋅Kelley, Mark⋅Kelley, Mark⋅Robertson, Kent and Robertson, Kent A
Experimental hematology, vol. 38, (no. 12), pp. 1178-88, 2010/Dec. | Journal Article
 
Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.
Bapat, Aditi⋅Bapat, Aditi⋅Glass, Lateca S⋅Glass, Lateca S⋅Luo, Meihua⋅Luo, Meihua⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Long, Eric C⋅Long, Eric C⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Kelley, Mark R and Kelley, Mark
The Journal of pharmacology and experimental therapeutics, vol. 334, (no. 3), pp. 988-98, 2010/Sep/1. | Journal Article
 
Redox regulation of DNA repair: implications for human health and cancer therapeutic development.
Luo, Meihua⋅He, Hongzhen⋅Kelley, Mark and Georgiadis, Millie M
Antioxidants & redox signaling, vol. 12, (no. 11), pp. 1247-69, 2010/Jun/1. | Journal Article
 
Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.
Jiang, Yanlin⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Zhou, Shaoyu⋅Zhou, Shaoyu⋅Zhou, Shaoyu⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Kelley, Mark⋅Kelley, Mark R⋅Kelley, Mark R⋅Fishel, Melissa L⋅Fishel, Melissa L and Fishel, Melissa L
Cancer investigation, vol. 28, (no. 9), pp. 885-95, 2010/Nov. | Journal Article
 
Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library
Glass, LaTeca S⋅Bapat, Aditi⋅Kelley, Mark R⋅Georgiadis, Millie M and Long, Eric C
Bioorganic and Medicinal Chemistry Letters, vol. 20, (no. 5), pp. 1685-1688, 2010. | Journal Article
2009
APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process ,
Vascotto, Carlo⋅Fantini, Damiano⋅Romanello, Milena⋅Cesaratto, Laura⋅Deganuto, Marta⋅Leonardi, Antonio⋅Radicella, JPablo⋅Kelley, Mark R⋅D'Ambrosio, Chiara⋅Scaloni, Andrea⋅Quadrifoglio, Franco and Tell, Gianluca
Molecular and Cellular Biology, vol. 29, (no. 7), pp. 1834-1854, 2009. | Journal Article