The research interests of my group are focused on the study of low molecular weight DNA and RNA binding agents due to the ability of such compounds to act as anticancer drugs, nucleic acid structural probes, and models to understand the fundamental molecular recognition of these vital biopolymers. We are engaged in two research directions: (1) the development and application of new experimental approaches to accelerate the discovery of DNA and RNA-targeted agents and (2) DNA recognition studies of synthetic, peptide-based agents, as well as a family of naturally-occurring, clinically used anti-tumor glycopeptides – the bleomycins.
