75 Publications (Page 2 of 3)
2011
Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme.
Su, Dian⋅Delaplane, Sarah⋅Luo, Meihua⋅Rempel, Don L⋅Vu, Bich⋅Kelley, Mark⋅Gross, Michael L and Georgiadis, Millie M
Biochemistry, vol. 50, (no. 1), pp. 82-92, 2011/Jan/11. | Journal Article
 
S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.
Kim, Yun-Jeong⋅Kim, Daemyung⋅Illuzzi, Jennifer L⋅Delaplane, Sarah⋅Su, Dian⋅Bernier, Michel⋅Gross, Michael L⋅Georgiadis, Millie M and Wilson, David M
Journal of molecular biology, vol. 414, (no. 3), pp. 313-26, 2011/Dec/2. | Journal Article
2010
Abstract 1963: Novel small molecule inhibitor of the endonuclease function of the APE1 DNA repair and redox signaling enzyme blocks proliferation and reduces viability of glioblastoma cells
Bapat, Aditi⋅Bapat, Aditi⋅Bapat, Aditi⋅Bapat, Aditi⋅Glass, LaTeca S⋅Glass, LaTeca S⋅Glass, LaTeca S⋅Glass, LaTeca S⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Reed, April⋅Reed, April⋅Reed, April⋅Reed, April⋅Long, Eric C⋅Long, Eric C⋅Long, Eric C⋅Long, Eric C⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R and Kelley, Mark R
Cancer Research, vol. 70, (no. 8 Supplement), pp. 1963, 2010-04-15. | Journal Article
 
Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme Metnase.
Goodwin, Kristie D⋅He, Hongzhen⋅Imasaki, Tsuyoshi⋅Lee, Suk Hee and Georgiadis, Millie M
Biochemistry, vol. 49, (no. 27), pp. 5705-13, 2010/Jul/13. | Journal Article
 
Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.
Bapat, Aditi⋅Bapat, Aditi⋅Glass, Lateca S⋅Glass, Lateca S⋅Luo, Meihua⋅Luo, Meihua⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Long, Eric C⋅Long, Eric C⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Kelley, Mark R and Kelley, Mark
The Journal of pharmacology and experimental therapeutics, vol. 334, (no. 3), pp. 988-98, 2010/Sep/1. | Journal Article
 
Redox regulation of DNA repair: implications for human health and cancer therapeutic development.
Luo, Meihua⋅He, Hongzhen⋅Kelley, Mark and Georgiadis, Millie M
Antioxidants & redox signaling, vol. 12, (no. 11), pp. 1247-69, 2010/Jun/1. | Journal Article
 
Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library
Glass, LaTeca S⋅Bapat, Aditi⋅Kelley, Mark R⋅Georgiadis, Millie M and Long, Eric C
Bioorganic and Medicinal Chemistry Letters, vol. 20, (no. 5), pp. 1685-1688, 2010. | Journal Article
 
Targeting the OB-Folds of Replication Protein A with Small Molecules.
Anciano Granadillo, Victor J⋅Earley, Jennifer N⋅Shuck, Sarah C⋅Georgiadis, Millie M⋅Fitch, Richard W and Turchi, John J
Journal of nucleic acids, vol. 2010, pp. 304035, 2010. | Journal Article
2009
Crystal structure of a trypanocidal 4,4?-bisdiphenylamine bound to DNA
Glass, LaTeca⋅Glass, LaTeca⋅Nguyen, Binh⋅Nguyen, Binh⋅Goodwin, Kristie⋅Goodwin, Kristie⋅Dardonville, Christophe⋅Dardonville, Christophe⋅Wilson, W.⋅Wilson, W.⋅Long, Eric⋅Long, Eric⋅Georgiadis, Millie and Georgiadis, Millie
Biochemistry, vol. 48, (no. 25), pp. 5943, 20090630. | Journal Article
 
Crystal Structure of a Trypanocidal 4,4'-Bis(imidazolinylamino)diphenylamine Bound to DNA,
Glass, Lateca S⋅Nguyen, Binh⋅Goodwin, Kristie D⋅Dardonville, Christophe⋅Wilson, William D⋅Long, Eric C and Georgiadis, Millie M
Biochemistry (Washington), vol. 48, (no. 25), pp. 5943-5952, 2009. | Journal Article
2008
Crystal structure of DNA-bound Cobleomycin [B.sub.2]: insights on intercalation and minor groove binding
Goodwin, Kristie⋅Goodwin, Kristie⋅Lewis, Mark⋅Lewis, Mark⋅Long, Eric⋅Long, Eric⋅Georgiadis, Millie and Georgiadis, Millie
Proceedings of the National Academy of Sciences of the United States, vol. 105, (no. 13), pp. 5052, 20080401. | Journal Article
 
Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.
Goodwin, Kristie D⋅Lewis, Mark A⋅Long, Eric C and Georgiadis, Millie M
Proceedings of the National Academy of Sciences of the United States of America, vol. 105, (no. 13), pp. 5052-6, 2008/Apr/1. | Journal Article
 
Crystal structure of DNA-bound Co(III)·bleomycin B₂: Insights on intercalation and minor groove binding.
Goodwin, Kristie D⋅Lewis, Mark A⋅Long, Eric C and Georgiadis, Millie M
Proceedings of the National Academy of Sciences of the United States of America., vol. 105, (no. 13), pp. 5052-5056, 2008. | Journal Article
 
Crystal structure of DNA-bound Co(III)-bleomycin B^sub 2^: Insights on intercalation and minor groove binding
Goodwin, Kristie D⋅Lewis, Mark A⋅Long, Eric C and Georgiadis, Millie M
Proceedings of the National Academy of Sciences of the United States of America, vol. 105, (no. 13), Apr 1, 2008. | Journal Article
 
Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
Georgiadis, Millie M⋅Luo, M.⋅Gaur, RK⋅Delaplane, S.⋅Li, Xiaoman and Kelley, Mark R
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, vol. 643, (no. 1-2), pp. 54-63, 2008. | Journal Article
 
Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
Luo, M.⋅Luo, Meihua⋅Delaplane, Sarah⋅Delaplane, S.⋅Jiang, Aihua⋅Jiang, A.⋅Reed, April⋅Reed, A.⋅He, Y.⋅He, Ying⋅Fishel, Melissa⋅Fishel, M.⋅Nyland, 2nd, Rodney L⋅Nyland, RL I⋅Borch, Richard F⋅Borch, Rich F⋅Qiao, X.⋅Qiao, Xiaoxi⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Kelley, Mark R and Kelley, Mark R
Antioxidants and Redox Signaling, vol. 10, (no. 11), pp. 1853-1867, 2008. | Journal Article
2007
Biochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activity.
Roman, Yaritzabel⋅Oshige, Masahiko⋅Lee, Young-Ju⋅Goodwin, Kristie⋅Georgiadis, Millie M⋅Hromas, Robert A and Lee, Suk Hee
Biochemistry, vol. 46, (no. 40), pp. 11369-76, 2007/Oct/9. | Journal Article
 
Phosphorylation of SIMPL modulates RelA-associated NF-[kappa]B-dependent transcription
Kwon, Hyung-Joo⋅Harrington, Maureen⋅Goebl, Mark⋅Luo, Yong⋅Georgiadis, Millie⋅Montano, Sherwin⋅Kwon, Hyung-Joo⋅Harrington, Maureen⋅Goebl, Mark⋅Luo, Yong⋅Georgiadis, Millie⋅Montano, Sherwin⋅Kwon, Hyung-Joo⋅Goebl, Mark⋅Luo, Yong⋅Georgiadis, Millie⋅Montano, Sherwin and Harrington, Maureen
The American Journal of Physiology, vol. 292, (no. 3), pp. C1013, 20070301. | Journal Article
 
Phosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription.
Luo, Yong⋅Kwon, Hyung-Joo⋅Montano, Sherwin⋅Georgiadis, Millie M⋅Goebl, Mark G and Harrington, Maureen A
American journal of physiology. Cell physiology, vol. 292, (no. 3), pp. C1013-23, 2007/Mar. | Journal Article
 
Phosphorylation of SIMPL modulates RelA-associated NF- Kappa B-dependent transcription
Luo, Yong⋅Kwon, Hyung-Joo⋅Montano, Sherwin⋅Georgiadis, Millie M⋅Goebl, Mark G and Harrington, Maureen A
American Journal of Physiology: Cell Physiology, vol. 292, (no. 3), pp. C1013-C1023, 2007. | Journal Article
 
Phosphorylation of SIMPL modulates RelA-associated NF-κB-dependent transcription
Luo, Yong⋅Luo, Yong⋅Luo, Yong⋅Kwon, Hyung-Joo⋅Kwon, Hyung-Joo⋅Kwon, Hyung-Joo⋅Montano, Sherwin⋅Montano, Sherwin⋅Montano, Sherwin⋅Georgiadis, Millie⋅Georgiadis, Millie⋅Georgiadis, Millie⋅Goebl, Mark⋅Goebl, Mark⋅Goebl, Mark⋅Harrington, Maureen⋅Harrington, Maureen and Harrington, Maureen
American Journal of Physiology - Cell Physiology, vol. 292, (no. 3), pp. 1023, 2007-03-01. | Journal Article
 
Unusually Strong Binding to the DNA Minor Groove by a Highly Twisted Benzimidazole Diphenylether: Induced Fit and Bound Water
Tanious, FA⋅Laine, W.⋅Peixoto, P.⋅Bailly, C.⋅Goodwin, KD⋅Lewis, MA⋅Long, Eric C⋅Georgiadis, Millie M⋅Tidwell, Richard R and Wilson, William D
Biochemistry (Washington), vol. 46, (no. 23), pp. 6944-6956, 2007. | Journal Article
2006
A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a "highly twisted" benzimidazole-diamidine.
Goodwin, Kristie D⋅Lewis, Mark A⋅Tanious, Farial A⋅Tidwell, Richard R⋅Wilson, William D⋅Georgiadis, Millie M and Long, Eric C
Journal of the American Chemical Society, vol. 128, (no. 24), pp. 7846-54, 2006/Jun/21. | Journal Article
 
Crystal structures of oligonucleotides including the integrase processing site of the Moloney murine leukemia virus
Montano, Sherwin P⋅Cote, Marie L⋅Roth, Monica and Georgiadis, Millie M
Nucleic Acids Research, vol. 34, (no. 19), pp. 5353-5360, 2006. | Journal Article
 
Study of Interactions and Determination of Binding Affinity Constants of Ape1 to E3330
Vu, Bich T⋅Georgiadis, Millie M⋅Nyland, Rod⋅Borch, Richard⋅Kelley, Mark⋅Taylor, John S and Gross, Michael L
54th ASMS Conference Proceedings, 2006. | Journal Article