75 Publications (Page 1 of 3)
2023
A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1Das, Debanu⋅Das, Debanu⋅Duncton, Matthew A⋅Georgiadis, Taxiarchis M⋅Pellicena, Patricia⋅Clark, Jennifer⋅Sobol, Robert W⋅Georgiadis, Millie M⋅King-Underwood, John⋅Jobes, David V⋅Chang, Caleb⋅Gao, Yang⋅Deacon, Ashley M and WilsonIII, David MInternational Journal of Molecular Sciences, vol. 24, (no. 23), 2023.
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2020
Building better enzymes: Molecular basis of improved non‐natural nucleobase incorporation by an evolved DNA polymeraseOuaray, Zahra⋅Singh, Isha⋅Georgiadis, Millie M and Richards, Nigel G. JProtein Science, vol. 29, (no. 2), pp. 468, February 2020.
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2019
Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1Trilles, Richard⋅Trilles, Richard⋅Beglov, Dmitri⋅Beglov, Dmitri⋅Chen, Qiujia⋅Chen, Qiujia⋅He, Hongzhen⋅He, Hongzhen⋅Wireman, Randall⋅Wireman, Randall⋅Reed, April⋅Reed, April⋅Chennamadhavuni, Spandan⋅Chennamadhavuni, Spandan⋅Panek, James S⋅Panek, James S⋅Brown, Lauren E⋅Brown, Lauren E⋅Vajda, Sandor⋅Vajda, Sandor⋅Porco, Jr, John A⋅Porco, Jr, John A⋅Kelley, Mark R⋅Kelley, Mark R⋅Georgiadis, Millie M and Georgiadis, Millie MJournal of medicinal chemistry, vol. 62, (no. 4), pp. 1988, 2019-02-28.
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Hachimoji DNA and RNA: A genetic system with eight building blocksHoshika, Shuichi⋅Leal, Nicole A⋅Kim, Myong-Jung⋅Kim, Myong-Sang⋅Karalkar, Nilesh B⋅Kim, Hyo-Joong⋅Bates, Alison M⋅Watkins, Jr, Norman E⋅SantaLucia, Holly A⋅Meyer, Adam J⋅DasGupta, Saurja⋅Piccirilli, Joseph A⋅Ellington, Andrew D⋅SantaLucia, Jr, John⋅Georgiadis, Millie M and Benner, Steven AScience (New York, N.Y.), vol. 363, (no. 6429), pp. 887, 2019-02-22.
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2018
"Skinny" and "Fat" DNA: Two New Double Helices.Hoshika, Shuichi⋅Singh, Isha⋅Switzer, Christopher⋅Molt, Robert W⋅Leal, Nicole A⋅Kim, Myong-Jung⋅Kim, Myong-Sang⋅Kim, Hyo-Joong⋅Georgiadis, Millie M and Benner, Steven AJournal of the American Chemical Society, September 10, 2018.
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Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.Singh, Isha⋅Laos, Roberto⋅Hoshika, Shuichi⋅Benner, Steven A and Georgiadis, Millie MNucleic acids research, July 9, 2018.
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2017
Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulationsMolt, Jr, Robert W⋅Georgiadis, Millie M and Richards, Nigel G JNucleic acids research, vol. 45, (no. 7), pp. 3653, 2017-04-20.
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Structure and Biophysics for a Six Letter DNA Alphabet that Includes Imidazo[1,2‑a]‑1,3,5-triazine-2(8H)‑4(3H)‑dione (X) and 2,4-Diaminopyrimidine (K)Singh, Isha⋅Kim, Myong-Jung⋅Molt, Robert W⋅Hoshika, Shuichi⋅Benner, Steven A and Georgiadis, Millie MACS Synthetic Biology, vol. 6, (no. 11), pp. 2129, 20171117.
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Toward an Expanded Genome: Structural and Computational Characterization of an Artificially Expanded Genetic Information SystemRichards, Nigel G. J and Georgiadis, Millie MAccounts of Chemical Research, vol. 50, (no. 6), pp. 1382, 20170620.
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2016
Crystallization of and selenomethionine phasing strategy for a SETMAR–DNA complexChen, Qiujia and Georgiadis, MillieActa Crystallographica Section F, vol. 72, (no. 9), pp. 719, September 2016.
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Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neuronsGeorgiadis, Millie M⋅Georgiadis, Millie M⋅Chen, Qiujia⋅Chen, Qiujia⋅Meng, Jingwei⋅Meng, Jingwei⋅Guo, Chunlu⋅Guo, Chunlu⋅Wireman, Randall⋅Wireman, Randall⋅Reed, April⋅Reed, April⋅Vasko, Michael R⋅Vasko, Michael R⋅Kelley, Mark R and Kelley, Mark RDNA Repair, vol. 41, pp. 41, May 2016.
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2014
Crystal structures of GCN2 C-terminal domain: Insight into GCN2 regulationSingh, Isha⋅He, Hongzhen⋅Wek, Sheree⋅Dey, Souvik⋅Baird, Thomas⋅Wek, Ronald and Georgiadis, MillieActa Crystallographica Section A Foundations and Advances, vol. 70, (no. a1), pp. C1407, 2014-08-05.
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Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and MammalsHe, Hongzhen⋅He, Hongzhen⋅Singh, Isha⋅Singh, Isha⋅Wek, Sheree A⋅Wek, Sheree A⋅Dey, Souvik⋅Dey, Souvik⋅Baird, Thomas D⋅Baird, Thomas D⋅Wek, Ronald C⋅Wek, Ronald C⋅Georgiadis, Millie M and Georgiadis, Millie MThe Journal of biological chemistry, vol. 289, (no. 21), pp. 15034, 2014-May-23.
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High-Resolution Crystal Structures Reveal Plasticity in the Metal Binding Site of Apurinic/Apyrimidinic Endonuclease IHe, Hongzhen⋅Chen, Qiujia and Georgiadis, Millie MBiochemistry, vol. 53, (no. 41), pp. 6529, 20141021.
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Preliminary crystallographic analysis of SETMAR bound to DNAChen, Qiujia⋅Lee, Suk-Hee and Georgiadis, MillieActa Crystallographica Section A Foundations and Advances, vol. 70, (no. a1), pp. C206, 2014-08-05.
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The DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restart.Kim, Hyun-Suk⋅Chen, Qiujia⋅Kim, Sung-Kyung⋅Nickoloff, Jac A⋅Hromas, Robert⋅Georgiadis, Millie M and Lee, Suk-HeeThe Journal of biological chemistry, vol. 289, (no. 15), pp. 10930-8, 2014/Apr/11.
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The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognitionSingh, Isha⋅Singh, Isha⋅Jian, Yajun⋅Lian, Yajun⋅Li, Lei⋅Lian, Yajun⋅Li, Lei⋅Georgiadis, Millie M and Georgiadis, Millie MActa Crystallographica Section D, vol. 70, (no. 3), pp. 759, March 2014.
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The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition. CorrigendumSingh, Isha⋅Jian, Yajun⋅Li, Lei and Georgiadis, Millie MActa Crystallographica Section D, vol. 70, (no. 4), pp. 1173, April 2014.
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2013
Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.Zhang, Jun⋅Zhang, Jun⋅Luo, Meihua⋅Luo, Meihua⋅Marasco, Daniela⋅Marasco, Daniela⋅Logsdon, Derek⋅Logsdon, Derek⋅La Favers, Kaice A⋅Lafavers, Kaice A⋅Chen, Qiujia⋅Chen, Qiujia⋅Reed, April⋅Reed, April⋅Kelley, Mark⋅Kelley, Mark R⋅Gross, Michael L⋅Gross, Michael L⋅Georgiadis, Millie M and Georgiadis, Millie MBiochemistry, vol. 52, (no. 17), pp. 2955-66, 2013/Apr/30.
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2012
APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Kelley, Mark⋅Kelley, Mark R⋅Georgiadis, Millie M⋅Georgiadis, Millie M⋅Fishel, Melissa L and Fishel, Melissa LCurrent molecular pharmacology, vol. 5, (no. 1), pp. 36-53, 2012/Jan.
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APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1Kelley, Mark⋅Kelley, Mark⋅Kelley, Mark⋅Georgiadis, Millie⋅Georgiadis, Millie⋅Georgiadis, Millie⋅Fishel, Melissa⋅Fishel, Melissa and Fishel, MelissaCurrent Molecular Pharmacology, vol. 5, (no. 1), pp. 53, 2012-January.
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Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.Luo, Meihua⋅Zhang, Jun⋅He, Hongzhen⋅Su, Dian⋅Chen, Qiujia⋅Gross, Michael L⋅Kelley, Mark and Georgiadis, Millie MBiochemistry, vol. 51, (no. 2), pp. 695-705, 2012/Jan/17.
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2011
Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondiiOnyango, David O⋅Naguleswaran, Arunasalam⋅Delaplane, Sarah⋅Reed, April⋅Kelley, Mark R⋅Georgiadis, Millie M and Sullivan, William JDNA Repair, vol. 10, (no. 5), pp. 466-475, 2011.
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Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1Kelley, Mark R⋅Luo, M.⋅Reed, A.⋅Su, D.⋅Delaplane, S.⋅Borch, Rich F⋅Nyland, RL I⋅Gross, Michael L and Georgiadis, Millie MAntioxidants and Redox Signaling, vol. 14, (no. 8), pp. 1387-1401, 2011.
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Interactions of apurinic/apyrimidinic endonuclease with aoxidative half-reaction : evidence for an alternate conformation of the enzymeSu, Dian⋅Su, Dian⋅Vu, Bich⋅Vu, Bich⋅Kelley, Mark⋅Kelley, Mark⋅Gross, Michael⋅Gross, Michael⋅Georgiadis, Millie⋅Georgiadis, Millie⋅Delaplane, Sarah⋅Delaplane, Sarah⋅Luo, Meihua⋅Luo, Meihua⋅Rempel, Don and Rempel, DonBiochemistry, vol. 50, (no. 1), pp. 82, 20110111.
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