157 Publications (Page 5 of 7)
2006
Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.
Joshi, Mandar A⋅Jeoung, Nam Ho⋅Obayashi, Mariko⋅Hattab, Eyas M⋅Brocken, Eric G⋅Liechty, Edward A⋅Kubek, Michael J⋅Vattem, Krishna M⋅Wek, Ronald C and Harris, Robert A
The Biochemical journal, vol. 400, (no. 1), pp. 153-162, November 15, 2006. | Journal Article
 
Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus
Carnevalli, Larissa S⋅Pereira, Catia M⋅Jaqueta, Carolina B⋅Alves, Viviane S⋅Paiva, Vanessa N⋅Vattem, Krishna M⋅Wek, Ronald⋅Mello, Luiz E and Castilho, Beatriz A
Biochemical Journal, vol. 397, (no. 1), pp. 187-194, 2006. | Journal Article
 
Phosphorylation of the α subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus
Carnevalli, Larissa S⋅Pereira, Catia M⋅Jaqueta, Carolina B⋅Alves, Viviane S⋅Paiva, Vanessa N⋅Vattem, Krishna M⋅Wek, Ronald C⋅Mello, Luiz Eugênio A M and Castilho, Beatriz A
The Biochemical journal, vol. 397, (no. 1), pp. 194, 2006-Jul-01. | Journal Article
 
Role of Glutamine Depletion in Directing Tissue-specific Nutrient Stress Responses to L-Asparaginase
Reinert, Rachel B⋅Oberle, L. M⋅Wek, Sheree A⋅Bunpo, Piyawan⋅Wang, Xue P⋅Mileva, Izolda⋅Goodwin, Leslie O⋅Aldrich, Carla J⋅Durden, Donald L⋅McNurlan, Margaret A⋅Wek, Ronald⋅others and Anthony, Tracy G
Journal of biological chemistry., vol. 281, (no. 42), pp. 31222-31233, 2006. | Journal Article
2005
GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation.
Jiang, Hao-Yuan and Wek, Ronald C
The Biochemical journal, vol. 385, pp. 371-380, January 15, 2005. | Journal Article
 
IMPACT, a Protein Preferentially Expressed in the Mouse Brain, Binds GCN1 and Inhibits GCN2 Activation.
Pereira, Cátia M⋅Sattlegger, Evelyn⋅Jiang, Hao-Yuan⋅Longo, Beatriz M⋅Jaqueta, Carolina B⋅Hinnebusch, Alan G⋅Wek, Ronald⋅Mello, Luiz E and Castilho, Beatriz A
Journal of biological chemistry., vol. 280, (no. 31), pp. 28316-28323, 2005. | Journal Article
 
Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition.
Jiang, Hao-Yuan and Wek, Ronald C
The Journal of biological chemistry, vol. 280, (no. 14), pp. 14189-14202, April 8, 2005. | Journal Article
 
Phosphorylation of the α-Subunit of the Eukaryotic Initiation Factor-2 (eIF2α) Reduces Protein Synthesis and Enhances Apoptosis in Response to Proteasome Inhibition
Jiang, Hao-Yuan and Wek, Ronald C
The Journal of biological chemistry, vol. 280, (no. 14), pp. 14202, 2005-Apr-08. | Journal Article
 
Stress-Activated Protein Kinase Pathway Functions To Support Protein Synthesis and Translational Adaptation in Response to Environmental Stress in Fission Yeast
Dunand-Sauthier, Isabelle⋅Walker, Carol A⋅Narasimhan, Jana⋅Pearce, Amanda K⋅Wek, Ronald C and Humphrey, Tim
Eukaryotic Cell, vol. 4, (no. 11), pp. 1785-1793, 2005. | Journal Article
 
Uncharged tRNA and Sensing of Amino Acid Deficiency in Mammalian Piriform Cortex
Hao, Shuzhen⋅Hao, Shuzhen⋅Sharp, James W⋅Sharp, James⋅Ross-Inta, Catherine M⋅Ross-Inta, Catherine⋅McDaniel, Brent J⋅McDaniel, Brent⋅Anthony, Tracy G⋅Anthony, Tracy⋅Wek, Ronald⋅Wek, Ronald⋅Cavener, Douglas R⋅Cavener, Douglas⋅McGrath, Barbara⋅McGrath, Barbara C⋅Rudell, John B⋅Rudell, John⋅Koehnle, Thomas⋅Koehnle, Thomas⋅Gietzen, Dorothy W⋅Gietzen, Dorothy and others
Science., vol. 307, (no. 5716), pp. 1776-1778, 2005. | Journal Article
2004
Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.
Jiang, Hao-Yuan⋅Wek, Sheree A⋅McGrath, Barbara C⋅Lu, Dan⋅Hai, Tsonwin⋅Harding, Heather P⋅Wang, Xiaozhong Alec⋅Ron, David⋅Cavener, Douglas R and Wek, Ronald C
Molecular and cellular biology, vol. 24, (no. 3), pp. 1365-77, 2004/Feb. | Journal Article
 
Differential Activation of eIF2 Kinases in Response to Cellular Stresses in Schizosaccharomyces pombe
Zhan, Ke⋅Narasimhan, Jana and Wek, Ronald
Genetics, vol. 168, (no. 4), pp. 1867-1875, Dec 2004. | Journal Article
 
Dimerization Is Required for Activation of eIF2 Kinase Gcn2 in Response to Diverse Environmental Stress Conditions
Narasimhan, J.⋅Narasimhan, Jana⋅Staschke, KA⋅Staschke, Kirk⋅Wek, Ronald and Wek, Ronald
Journal of Biological Chemistry, vol. 279, (no. 22), pp. 22820-22832, 2004. | Journal Article
 
Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control.
Sullivan, William J⋅Narasimhan, Jana⋅Bhatti, Micah M and Wek, Ronald C
The Biochemical journal. , vol. 380, (no. Pt 2), pp. 523-31, 2004/Jun/1. | Journal Article
 
Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2
Anthony, Tracy G⋅Anthony, Tracy G⋅McDaniel, Brent J⋅Mcdaniel, Brent J⋅McDaniel, Brent J⋅Byerley, Rachel L⋅Byerley, Rachel L⋅Mcgrath, Barbara C⋅McGrath, Barbara C⋅McGrath, Barbara C⋅Cavener, Douglas R⋅Cavener, Douglas R⋅McNurlan, Margaret A⋅McNurlan, Margaret A⋅Mcnurlan, Margaret A⋅Wek, Ronald and Wek, Ronald C
Journal of Biological Chemistry, vol. 279, (no. 35), pp. 36553-36561, 2004. | Journal Article
 
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells.
Vattem, Krishna M and Wek, Ronald C
Proceedings of the National Academy of Sciences of the United States of America, vol. 101, (no. 31), pp. 11269-11274, August 3, 2004. | Journal Article
 
Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity.
Senée, Valérie⋅Vattem, Krishna M⋅Delépine, Marc⋅Rainbow, Lynn A⋅Haton, Céline⋅Lecoq, Annick⋅Shaw, Nick J⋅Robert, Jean-Jacques⋅Rooman, Raoul⋅Diatloff-Zito, Catherine⋅Michaud, Jacques L⋅Bin-Abbas, Bassan⋅Taha, Doris⋅Zabel, Bernard⋅Franceschini, Piergiorgio⋅Topaloglu, A K⋅Lathrop, G M⋅Barrett, Timothy G⋅Nicolino, Marc⋅Wek, Ronald C and Julier, Cécile
Diabetes, vol. 53, (no. 7), pp. 1876-83, 2004/Jul. | Journal Article
2003
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses.
Jiang, Hao-Yuan⋅Wek, Sheree A⋅McGrath, Barbara C⋅Scheuner, Donalyn⋅Kaufman, Randal J⋅Cavener, Douglas R and Wek, Ronald C
Molecular and cellular biology, vol. 23, (no. 16), pp. 5651-63, 2003/Aug. | Journal Article
 
Phosphorylation of the alpha Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF- Kappa B in Response to Diverse Cellular Stresses
Jiang, H-Y⋅Wek, SA⋅McGrath, BC⋅Scheuner, D.⋅Kaufman, RJ⋅Cavener, Douglas R and Wek, Ronald
Molecular and Cellular Biology, vol. 23, (no. 16), pp. 5651-5663, 2003. | Journal Article
 
Site-directed mutagenesis of the active site of diacylglycerol kinase α: calcium and phosphatidylserine stimulate enzyme activity via distinct mechanisms
Abe, Takahiro⋅Lu, Xiaolan⋅Jiang, Ying⋅Boccone, Clark E⋅Qian, Shaomin⋅Vattem, Krishna M⋅Wek, Ronald C and Walsh, James P
The Biochemical journal, vol. 375, (no. Pt 3), pp. 680, 2003-Nov-01. | Journal Article
2002
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress.
Ma, Kun⋅Vattem, Krishna M and Wek, Ronald C
The Journal of biological chemistry, vol. 277, (no. 21), pp. 18728-35, 2002/May/24. | Journal Article
 
Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses.
Zhan, Ke⋅Vattem, Krishna M⋅Bauer, Bettina N⋅Dever, Thomas E⋅Chen, Jane-Jane and Wek, Ronald C
Molecular and cellular biology, vol. 22, (no. 20), pp. 7134-46, 2002/Oct. | Journal Article
 
Phosphorylation of Eukaryotic Initiation Factor 2 by Heme-Regulated Inhibitor Kinase-Related Protein Kinases in Schizosaccharomyces pombe Is Important for Resistance to Environmental Stresses
Zhan, Ke⋅Vattem, KM⋅Bauer, BN⋅Dever, TE⋅Chen, J. and Wek, Ronald
Molecular and Cellular Biology, vol. 22, (no. 20), pp. 7134-7146, 2002. | Journal Article
 
Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame.
Fernandez, James⋅Yaman, Ibrahim⋅Merrick, William C⋅Koromilas, Antonis⋅Wek, Ronald C⋅Sood, Rushira⋅Hensold, Jack and Hatzoglou, Maria
The Journal of biological chemistry, vol. 277, (no. 3), pp. 2050-8, 2002/Jan/18. | Journal Article
 
Regulation of Internal Ribosome Entry Site-mediated Translation by Eukaryotic Initiation Factor-2 alpha Phosphorylation and Translation of a Small Upstream Open Reading Frame
Fernandez, J.⋅Yaman, I.⋅Merrick, William C⋅Koromilas, Antonis⋅Wek, Ronald⋅Sood, R.⋅Hensold, J. and Hatzoglou, Maria
Journal of Biological Chemistry, vol. 277, (no. 3), pp. 2050-2058, 2002. | Journal Article