152 Publications (Page 1 of 7)
2021
Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
Misra, JagannathHolmes, Michael JT. Mirek, EmilyLangevin, MichaelKim, Hyeong-GeugCarlson, Kenneth RWatford, MalcolmDong, X CharlieAnthony, Tracy G and Wek, Ronald C
Nucleic Acids Research, vol. 49, pp. 5726–5742. | Journal Article
 
Host sensing and signal transduction during Toxoplasma stage conversion
Augusto, LeonardoWek, Ronald C. and Sullivan, William J.
Molecular Microbiology, vol. 115, pp. 839–848. | Journal Article
2019
Adapting to cell stress from inside and out
Staschke, Kirk AStaschke, Kirk AWek, Ronald C and Wek, Ronald C
Nature cell biology, vol. 21, (no. 7), pp. 800, 2019-07-00. | Journal Article
 
Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation
Martynowicz, JenniferAugusto, LeonardoWek, Ronald CBoehm, 2nd, Stephen L and Sullivan, Jr, William J
mBio, vol. 10, (no. 2), pp. e00381-19, 2019-04-30. | Journal Article
 
Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality
Shao, YuShao, YuShao, YuShao, YuShao, YuShao, YuShao, YuWichern, EmilyWichern, EmilyWichern, EmilyWichern, EmilyWichern, EmilyWichern, EmilyWichern, EmilyChildress, Paul JChildress, Paul JChildress, Paul JChildress, Paul JChildress, Paul JChildress, Paul JChildress, Paul JAdaway, MicheleAdaway, MicheleAdaway, MicheleAdaway, MicheleAdaway, MicheleAdaway, MicheleAdaway, MicheleMisra, JagannathMisra, JagannathMisra, JagannathMisra, JagannathMisra, JagannathMisra, JagannathMisra, JagannathKlunk, AngelaKlunk, AngelaKlunk, AngelaKlunk, AngelaKlunk, AngelaKlunk, AngelaKlunk, AngelaBurr, David BBurr, David BBurr, David BBurr, David BBurr, David BBurr, David BBurr, David BWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CMosley, Amber LMosley, Amber LMosley, Amber LMosley, Amber LMosley, Amber LMosley, Amber LMosley, Amber LLiu, YunlongLiu, YunlongLiu, YunlongLiu, YunlongLiu, YunlongLiu, YunlongLiu, YunlongRobling, Alexander GRobling, Alexander GRobling, Alexander GRobling, Alexander GRobling, Alexander GRobling, Alexander GRobling, Alexander GBrustovetsky, NickolayBrustovetsky, NickolayBrustovetsky, NickolayBrustovetsky, NickolayBrustovetsky, NickolayBrustovetsky, NickolayBrustovetsky, NickolayHamilton, JamesHamilton, JamesHamilton, JamesHamilton, JamesHamilton, JamesHamilton, JamesHamilton, JamesJacobs, KylieJacobs, KylieJacobs, KylieJacobs, KylieJacobs, KylieJacobs, KylieJacobs, KylieVashishth, DeepakVashishth, DeepakVashishth, DeepakVashishth, DeepakVashishth, DeepakVashishth, DeepakVashishth, DeepakStayrook, Keith RStayrook, Keith RStayrook, Keith RStayrook, Keith RStayrook, Keith RStayrook, Keith RStayrook, Keith RAllen, Matthew RAllen, Matthew RAllen, Matthew RAllen, Matthew RAllen, Matthew RAllen, Matthew RAllen, Matthew RWallace, Joseph MWallace, Joseph MWallace, Joseph MWallace, Joseph MWallace, Joseph MWallace, Joseph MWallace, Joseph MBidwell, Joseph PBidwell, Joseph PBidwell, Joseph PBidwell, Joseph PBidwell, Joseph PBidwell, Joseph P and Bidwell, Joseph P
American journal of physiology. Endocrinology and metabolism, vol. 316, (no. 5), pp. E772, 2019-05-01. | Journal Article
 
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion
Jiang, JieJiang, JieJiang, JieJiang, JieSrivastava, SankalpSrivastava, SankalpSrivastava, SankalpSrivastava, SankalpSeim, GretchenSeim, GretchenSeim, GretchenSeim, GretchenPavlova, Natalya NPavlova, Natalya NPavlova, Natalya NPavlova, Natalya NKing, BryanKing, BryanKing, BryanKing, BryanZou, LihuaZou, LihuaZou, LihuaZou, LihuaZhang, ChiZhang, ChiZhang, ChiZhang, ChiZhong, MinghuaZhong, MinghuaZhong, MinghuaZhong, MinghuaFeng, HuiFeng, HuiFeng, HuiFeng, HuiKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CFan, JingFan, JingFan, JingFan, JingZhang, JiZhang, JiZhang, Ji and Zhang, Ji
The Journal of biological chemistry, vol. 294, (no. 49), pp. 18684, 2019-Dec-06. | Journal Article
 
Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii
Augusto, LeonardoAugusto, LeonardoAmin, Parth HAmin, Parth HWek, Ronald CWek, Ronald CSullivan, William J and Sullivan, Jr, William J
PLoS pathogens, vol. 15, (no. 6), pp. e1007746, 2019-06-00. | Journal Article
 
Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii
Holmes, Michael JHolmes, Michael JShah, PremalShah, PremalWek, Ronald CWek, Ronald CSullivan, William J and Sullivan, Jr, William J
mSphere, vol. 4, (no. 3), pp. e00292-19, 2019-06-05. | Journal Article
2018
Effects of PERK eIF2α kinase inhibitor against Toxoplasma gondii.
Augusto, LeonardoAugusto, LeonardoMartynowicz, JenniferMartynowicz, JenniferStaschke, Kirk AStaschke, Kirk AWek, Ronald CWek, Ronald CSullivan, William J and Sullivan, Jr, William J
Antimicrobial agents and chemotherapy, September 4, 2018. | Journal Article
 
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
Ogbechi, JoyOgbechi, JoyHall, Belinda SHall, Belinda SSbarrato, ThomasSbarrato, ThomasTaunton, JackTaunton, JackWillis, Anne EWillis, Anne EWek, Ronald CWek, Ronald CSimmonds, Rachel E and Simmonds, Rachel E
Cell death & disease, vol. 9, (no. 3), pp. 15, 2018-03-14. | Journal Article
 
Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress.
Wek, Ronald C
Cold Spring Harbor perspectives in biology, February 12, 2018. | Journal Article
 
Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver
Nikonorova, Inna AMirek, Emily TSignore, Christina CGoudie, Michael PWek, Ronald C and Anthony, Tracy G
The Journal of biological chemistry, vol. 293, (no. 14), pp. 5015, 2018-04-06. | Journal Article
 
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes
Collier, Ann ECollier, Ann ESpandau, Dan FSpandau, Dan FWek, Ronald C and Wek, Ronald C
Molecular biology of the cell, vol. 29, (no. 1), pp. 41, 2018-01-01. | Journal Article
2017
Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice123
Pettit, A.P.Pettit, Ashley PJonsson, William OJonsson, W.O.Bargoud, Albert RBargoud, A.R.Mirek, E.T.Mirek, Emily TPeelor, F.F.Peelor, Frederick FWang, Y.Wang, YongpingGettys, T.W.Gettys, Thomas WKimball, Scot RKimball, S.R.Miller, Benjamin FMiller, B.F.Hamilton, K.L.Hamilton, Karyn LWek, R.C.Wek, Ronald CAnthony, T.G. and Anthony, Tracy G
The Journal of Nutrition, vol. 147, (no. 6), pp. 1040, 2017-04-26. | Journal Article
 
Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response
Willy, Jeffrey AWilly, Jeffrey AWilly, Jeffrey AWilly, Jeffrey AYoung, Sara KYoung, Sara KYoung, Sara KYoung, Sara KMosley, Amber LMosley, Amber LMosley, Amber LMosley, Amber LGawrieh, SamerGawrieh, SamerGawrieh, SamerGawrieh, SamerStevens, James LStevens, James LStevens, James LStevens, James LMasuoka, Howard CMasuoka, Howard CMasuoka, Howard CMasuoka, Howard CWek, Ronald CWek, Ronald CWek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 292, (no. 34), pp. 14065, 2017-08-25. | Journal Article
 
Human keratinocyte differentiation requires translational control by the eIF2α kinase GCN2.
Collier, Ann ECollier, Ann EWek, Ronald CWek, Ronald CSpandau, Dan F and Spandau, Dan F
The Journal of investigative dermatology, May 17, 2017. | Journal Article
 
Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism
Shao, YuShao, YuShao, YuShao, YuShao, YuShao, YuShao, YuHernandez-Buquer, SeleneHernandez-Buquer, SeleneHernandez-Buquer, SeleneHernandez-Buquer, SeleneHernandez-Buquer, SeleneHernandez-Buquer, SeleneHernandez-Buquer, SeleneChildress, PaulChildress, PaulChildress, PaulChildress, PaulChildress, PaulChildress, PaulChildress, PaulStayrook, Keith RStayrook, Keith RStayrook, Keith RStayrook, Keith RStayrook, Keith RStayrook, Keith RStayrook, Keith RAlvarez, Marta BAlvarez, Marta BAlvarez, Marta BAlvarez, Marta BAlvarez, Marta BAlvarez, Marta BAlvarez, Marta BDavis, HannahDavis, HannahDavis, HannahDavis, HannahDavis, HannahDavis, HannahDavis, HannahPlotkin, Lilian IPlotkin, Lilian IPlotkin, Lilian IPlotkin, Lilian IPlotkin, Lilian IPlotkin, Lilian IPlotkin, Lilian IHe, YongzhengHe, YongzhengHe, YongzhengHe, YongzhengHe, YongzhengHe, YongzhengHe, YongzhengCondon, Keith WCondon, Keith WCondon, Keith WCondon, Keith WCondon, Keith WCondon, Keith WCondon, Keith WBurr, David BBurr, David BBurr, David BBurr, David BBurr, David BBurr, David BBurr, David BWarden, Stuart JWarden, Stuart JWarden, Stuart JWarden, Stuart JWarden, Stuart JWarden, Stuart JWarden, Stuart JRobling, Alexander GRobling, Alexander GRobling, Alexander GRobling, Alexander GRobling, Alexander GRobling, Alexander GRobling, Alexander GYang, Feng-ChunYang, Feng-ChunYang, Feng-ChunYang, Feng-ChunYang, Feng-ChunYang, Feng-ChunYang, Feng ChunWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CAllen, Matthew RAllen, Matthew RAllen, Matthew RAllen, Matthew RAllen, Matthew RAllen, Matthew RAllen, Matthew RBidwell, Joseph PBidwell, Joseph PBidwell, Joseph PBidwell, Joseph PBidwell, Joseph PBidwell, Joseph P and Bidwell, Joseph P
Endocrinology, vol. 158, (no. 9), pp. 2740, 2017-09-01. | Journal Article
 
Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency
Zhang, MinZhang, MinGallego-Delgado, JulioGallego-Delgado, JulioFernandez-Arias, CristinaFernandez-Arias, CristinaWaters, Norman CWaters, Norman CRodriguez, AnaRodriguez, AnaTsuji, MoriyaTsuji, MoriyaWek, Ronald CWek, Ronald CNussenzweig, VictorNussenzweig, VictorSullivan, William J and Sullivan, William J
Cell Host & Microbe, vol. 22, (no. 6), pp. 776.e4, 2017-12-13. | Journal Article
 
Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice
Nikonorova, I.A.Nikonorova, I.A.Nikonorova, Inna AAl-Baghdadi, R.J.T.Al-Baghdadi, Rana J TAl-Baghdadi, R.J.T.Mirek, E.T.Mirek, Emily TMirek, E.T.Wang, Y.Wang, Y.Wang, YongpingGoudie, M.P.Goudie, Michael PGoudie, M.P.Wetstein, B.B.Wetstein, B.B.Wetstein, Berish BDixon, Joseph LDixon, J.L.Dixon, J.L.Hine, ChristopherHine, C.Hine, C.Mitchell, James RMitchell, J.R.Mitchell, J.R.Adams, C.M.Adams, C.M.Adams, Christopher MWek, X.R.C.Wek, X.R.C.Wek, Ronald CAnthony, T.G.Anthony, T.G. and Anthony, Tracy G
The Journal of biological chemistry, vol. 292, (no. 16), pp. 6798, 2017-04-21. | Journal Article
 
Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.
Anthony, TracyAl-Baghdadi, Rana J TNikonorova, Inna AMirek, Emily TWang, YongpingPark, JinheeBelden, William JWek, Ronald C and Anthony, Tracy G
Scientific reports, vol. 7, (no. 1), pp. 1272, April 28, 2017. | Journal Article
 
Translational Control in the Latency of Apicomplexan Parasites
Holmes, Michael JHolmes, Michael JAugusto, Leonardo da SilvaAugusto, Leonardo da SilvaZhang, MinZhang, MinWek, Ronald CWek, Ronald CSullivan, William J and Sullivan, William J
Trends in Parasitology, vol. 33, (no. 12), pp. 960, December 2017. | Journal Article
2016
ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis
Srivastava, Ritesh KLi, ChangzhaoAhmad, AftabAbrams, OnikaGorbatyuk, Marina SHarrod, Kevin SWek, Ronald CAfaq, Farrukh and Athar, Mohammad
Archives of Biochemistry and Biophysics, vol. 609, pp. 50, 2016-11-01. | Journal Article
 
General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.
Phillipson-Weiner, LindseyMirek, Emily TWang, YongpingMcAuliffe, W GeoffreyWek, Ronald C and Anthony, Tracy G
American journal of physiology. Gastrointestinal and liver physiology, vol. 310, (no. 11), pp. G1061-G1070, June 1, 2016. | Journal Article
 
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential
Kwon, Jason JKwon, Jason JKwon, Jason JWilly, Jeffrey AWilly, Jeffrey AWilly, Jeffrey AQuirin, Kayla AQuirin, Kayla AQuirin, Kayla AWek, Ronald CWek, Ronald CWek, Ronald CKorc, MurrayKorc, MurrayKorc, MurrayYin, Xiao-MingYin, Xiao-MingYin, Xiao MingKota, JanaiahKota, Janaiah and Kota, Janaiah
Oncotarget, vol. 7, (no. 44), pp. 71650, 2016-11-01. | Journal Article
 
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
Young, Sara KYoung, Sara KShao, YuShao, YuBidwell, Joseph PBidwell, Joseph PWek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 26), pp. 13780-13788, June 24, 2016. | Journal Article