157 Publications (Page 2 of 7)
2017
Translational Control in the Latency of Apicomplexan Parasites
Holmes, Michael JHolmes, Michael JAugusto, Leonardo da SilvaAugusto, Leonardo da SilvaZhang, MinZhang, MinWek, Ronald CWek, Ronald CSullivan, William J and Sullivan, William J
Trends in Parasitology, vol. 33, (no. 12), pp. 960, December 2017. | Journal Article
2016
ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis
Srivastava, Ritesh KLi, ChangzhaoAhmad, AftabAbrams, OnikaGorbatyuk, Marina SHarrod, Kevin SWek, Ronald CAfaq, Farrukh and Athar, Mohammad
Archives of Biochemistry and Biophysics, vol. 609, pp. 50, 2016-11-01. | Journal Article
 
General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.
Phillipson-Weiner, LindseyPhillipson-Weiner, LindseyMirek, Emily TMirek, Emily TWang, YongpingWang, YongpingMcAuliffe, W GeoffreyMcAuliffe, W GeoffreyWek, Ronald CWek, Ronald CAnthony, Tracy G and Anthony, Tracy G
American journal of physiology. Gastrointestinal and liver physiology, vol. 310, (no. 11), pp. G1061-G1070, June 1, 2016. | Journal Article
 
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential
Kwon, Jason JKwon, Jason JKwon, Jason JWilly, Jeffrey AWilly, Jeffrey AWilly, Jeffrey AQuirin, Kayla AQuirin, Kayla AQuirin, Kayla AWek, Ronald CWek, Ronald CWek, Ronald CKorc, MurrayKorc, MurrayKorc, MurrayYin, Xiao-MingYin, Xiao-MingYin, Xiao MingKota, JanaiahKota, Janaiah and Kota, Janaiah
Oncotarget, vol. 7, (no. 44), pp. 71650, 2016-11-01. | Journal Article
 
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
Young, Sara KYoung, Sara KShao, YuShao, YuBidwell, Joseph PBidwell, Joseph PWek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 26), pp. 13780-13788, June 24, 2016. | Journal Article
 
Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response.
Young, Sara KYoung, Sara KPalam, Lakshmi ReddyPalam, Lakshmi ReddyWu, ChengWu, ChengSachs, Matthew SSachs, Matthew SWek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 12), pp. 6546-6558, March 18, 2016. | Journal Article
 
Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.
Fusakio, M.E.Fusakio, Michael EFusakio, Michael EWilly, J.A.Willy, Jeffrey AWilly, Jeffrey AWang, YongpingWang, YongpingWang, Y.Mirek, Emily TMirek, E.T.Mirek, Emily TBaghdadi, R.J.T.A.Baghdadi, R.J.T.A.Al Baghdadi, Rana J TAl Baghdadi, Rana J TAdams, C.M.Adams, Christopher MAdams, Christopher MAnthony, T.G.Anthony, Tracy GAnthony, Tracy GWek, Ronald CWek, Ronald C and Wek, R.C.
Molecular biology of the cell, vol. 27, (no. 9), pp. 1536-1551, May 1, 2016. | Journal Article
 
Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons.
Young, Sara KBaird, Thomas D and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 20), pp. 10824-10835, May 13, 2016. | Journal Article
 
Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response.
Young, Sara K and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 33), pp. 16927-16935, August 12, 2016. | Journal Article
2015
Bmi1 promotes erythroid development through regulating ribosome biogenesis.
Gao, RuiGao, RuiChen, SisiChen, SisiKobayashi, MichihiroKobayashi, MichihiroYu, HaoYu, HaoZhang, YingchiZhang, YingchiWan, YangWan, YangYoung, Sara KYoung, Sara KSoltis, AnthonySoltis, AnthonyYu, MingYu, MingVemula, SasidharVemula, SasidharFraenkel, ErnestFraenkel, ErnestCantor, AlanCantor, AlanAntipin, YevgeniyAntipin, YevgeniyXu, YangXu, YangYoder, Mervin CYoder, Mervin CWek, Ronald CWek, Ronald CEllis, Steven REllis, Steven RKapur, ReubenKapur, ReubenZhu, XiaofanZhu, XiaofanLiu, Yan and Liu, Yan
Stem cells (Dayton, Ohio), vol. 33, (no. 3), pp. 925-938, March 2015. | Journal Article
 
CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis.
Willy, Jeffrey AYoung, Sara KStevens, James LMasuoka, Howard C and Wek, Ronald C
Molecular biology of the cell, vol. 26, (no. 12), pp. 2190-2204, June 15, 2015. | Journal Article
 
GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.
Wilson, Gabriel JWilson, Gabriel JWilson, Gabriel JWilson, Gabriel JLennox, Brittany ALennox, Brittany ALennox, Brittany ALennox, Brittany AShe, PengxiangShe, PengxiangShe, PengxiangShe, PengxiangMirek, Emily TMirek, Emily TMirek, Emily TMirek, Emily TAl Baghdadi, Rana J TAl Baghdadi, Rana J TAl Baghdadi, Rana J TAl Baghdadi, Rana J TFusakio, Michael EFusakio, Michael EFusakio, Michael EFusakio, Michael EDixon, Joseph LDixon, Joseph LDixon, Joseph LDixon, Joseph LHenderson, Gregory CHenderson, Gregory CHenderson, Gregory CHenderson, Gregory CWek, Ronald CWek, Ronald CWek, Ronald CWek, Ronald CAnthony, Tracy GAnthony, Tracy GAnthony, Tracy G and Anthony, Tracy G
American journal of physiology. Endocrinology and metabolism, vol. 308, (no. 4), pp. E283-E293, February 15, 2015. | Journal Article
 
Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis.
Benmerzouga, ImaanCheckley, Lisa AFerdig, Michael TArrizabalaga, GustavoWek, Ronald C and Sullivan, William J
Antimicrobial agents and chemotherapy, vol. 59, (no. 11), pp. 6939-6945, November 2015. | Journal Article
 
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
Young, Sara KWilly, Jeffrey AWu, ChengSachs, Matthew S and Wek, Ronald C
The Journal of biological chemistry, vol. 290, (no. 47), pp. 28257-28271, November 20, 2015. | Journal Article
 
Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response.
Collier, Ann ECollier, Ann EWek, Ronald CWek, Ronald CSpandau, Dan F and Spandau, Dan F
The Journal of investigative dermatology, vol. 135, (no. 10), pp. 2502-2511, October 2015. | Journal Article
2014
Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals.
He, HongzhenHe, HongzhenSingh, IshaSingh, IshaWek, Sheree AWek, Sheree ADey, SouvikDey, SouvikBaird, Thomas DBaird, Thomas DWek, Ronald CWek, Ronald CGeorgiadis, Millie M and Georgiadis, Millie M
The Journal of biological chemistry, vol. 289, (no. 21), pp. 15023-34, 2014/May/23. | Journal Article
 
Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Cambiaghi, Tavane DPereira, Catia MShanmugam, RenukaBolech, MichaelWek, Ronald CSattlegger, Evelyn and Castilho, Beatriz A
Biochemical and biophysical research communications, vol. 443, (no. 2), pp. 592-7, 2014/Jan/10. | Journal Article
 
GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii.
Konrad, ChristianWek, Ronald C and Sullivan, William J
International journal for parasitology, vol. 44, (no. 2), pp. 139-46, 2014/Feb. | Journal Article
 
Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα
Baird, Thomas DBaird, T.D.Palam, Lakshmi ReddyPalam, L.R.Fusakio, M.E.Fusakio, Michael EWilly, Jeffrey AWilly, J.A.Davis, C.M.Davis, Christopher MMcClintick, J.N.McClintick, Jeanette NAnthony, Tracy GAnthony, T.G.Wek, Ronald C and Wek, R.C.
Molecular Biology of the Cell, vol. 25, pp. 1666-1675. | Journal Article
2013
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.
Teske, Brian FFusakio, Michael EZhou, DonghuiShan, JixiuMcClintick, Jeanette NKilberg, Michael S and Wek, Ronald C
Molecular biology of the cell, vol. 24, (no. 15), pp. 2477-90, 2013/Aug. | Journal Article
 
General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice.
She, PengxiangShe, PengxiangBunpo, PiyawanBunpo, PiyawanCundiff, Judy KCundiff, Judy K.Wek, Ronald CWek, Ronald C.Harris, Robert A.Harris, Robert AAnthony, Tracy G and Anthony, Tracy G.
The Journal of biological chemistry, vol. 288, (no. 43), pp. 31250-60, 2013/Oct/25. | Journal Article
 
Inhibitors of eIF2 alpha Dephosphorylation Slow Replication and Stabilize Latency in Toxoplasma gondii
Konrad, ChristianQueener, Sherry FWek, Ronald and Sullivan, William J
Antimicrobial Agents & Chemotherapy, vol. 57, (no. 4), pp. 1815-1822, 2013. | Journal Article
 
Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.
Konrad, ChristianQueener, Sherry FWek, Ronald C and Sullivan, William J
Antimicrobial agents and chemotherapy, vol. 57, (no. 4), pp. 1815-22, 2013/Apr. | Journal Article
 
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
Babcock, Justin TNguyen, Hoa BHe, YujunHendricks, Jeremiah WWek, Ronald C and Quilliam, Lawrence A
The Journal of biological chemistry, vol. 288, (no. 22), pp. 15687-98, 2013/May/31. | Journal Article
 
The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment
Wilson, Gabriel JWilson, Gabriel JBunpo, PiyawanBunpo, PiyawanCundiff, Judy KCundiff, Judy KWek, Ronald CWek, RonaldAnthony, Tracy G and Anthony, Tracy G
American Journal of Physiology, vol. 305, (no. 9), Nov 1, 2013. | Journal Article