Expertise

Specialization:

  • Anticancer drug discovery, Structure-based rational drug design, DNA G-quadruplex, NMR, Computer modeling

My research program focuses on structures and functions of cancer-specific DNA molecular targets and structure-based rational design of new anticancer drugs.

Research Interests:

  • DNA G-quadruplex secondary structures and functions
  • Interactions of DNA G-quadruplexes with small molecules and rational drug design
  • Protein interactions of DNA G-quadruplexes
  • Targeting DNA binding of transcription factors by novel DNA bis-intercalators

Research in my laboratory is focused on structures and functions of cancer-specific DNA molecular targets and structure-based rational design of new anticancer drugs.

Research Interests:

  • Structures and Functions of DNA G-quadruplexes
  • G4-targeting Drug Discovery
  • Target the MYC promoter G4 to suppress MYC oncogene
  • Targeting Human Telomeres
  • Protein interactions of DNA G-quadruplexes.

Research:

  • Cancer-specific DNA-related molecular targets & structure-based rational design
    • Structures and functions of DNA G-quadruplex secondary structures
    • Protein interactions of G-quadruplexes
    • Targeting G-quadruplexes for anticancer drug development.
    • Structure-based rational drug design

Subject Area:

  • cancer

Area of research:

  • Molecular and Cellular Pharmacology; Medicinal Chemistry and Chemical Biology; Biophysical and Computation Chemistry

 

Affiliations

Professor, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University

Adjunct Professor, IUSM West Lafayette, Indiana University School of Medicine

Professor, Department of Chemistry, College of Science, Purdue University

Purdue Center for Cancer Research, Office of Research, Purdue University

Past Affiliations

Bindley Bioscience Center, Discovery Park District, Office of Research, Purdue University (past)

Associate Dean, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University (past)

Chair, Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University (past)

Communities
Pharmacology, Chemistry
Degrees
PhD, University of Illinois at Urbana-Champaign, Biophysics, 1996
BS, University of Science and Technology of China, China, Molecular and Cell Biology, 1989