76 Publications (Page 1 of 4)
2024
Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine
2023
Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor
Hennessy, Madeline R.⋅Gutridge, Anna M.⋅French, Alexander R.⋅Rhoda, Elizabeth S.⋅Meqbil, Yazan J.⋅Gill, Meghna⋅Kashyap, Yavnika⋅Appourchaux, Kevin⋅Paul, Barnali⋅Wang, Zaijie Jim⋅Van Rijn, Richard M. and Riley, Andrew P.
Journal of medicinal chemistry, vol. 66, (no. 5), pp. 3326, 2023-03-09. | Journal Article
 
Receptor expression and signaling properties in the brain, and structural ligand motifs that contribute to delta opioid receptor agonist-induced seizures. Neuropharmacology
. | Journal Article
2022
An updated assessment of the translational promise of G-protein-biased kappa opioid receptor agonists to treat pain and other indications without debilitating adverse effects
French, Alexander R. and Rijn, Richard M.
Pharmacological Research, vol. 177, pp. 106091. | Journal Article
 
ClickArr: a novel, high throughput assay for evaluating β-arrestin isoform recruitment
 
Copper Modulates Adult Neurogenesis in Brain Subventricular Zone
Liu, Luke L⋅Van Rijn, Richard M⋅Zheng, Wei and Zheng, Wei
International Journal of Molecular Sciences, vol. 23, (no. 17), 2022. | Journal Article
 
Copper Modulates Adult Neurogenesis in Brain Subventricular Zone. International Journal of Molecular Sciences
 
Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II
Molecules. | Journal Article
 
Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II
Van Rijn, Richard M⋅Van Rijn, Richard M⋅Spetea, Mariana and Spetea, Mariana
2022
 
Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors
Meqbil, Yazan J⋅Van Rijn, Richard M and van Rijn, Richard M
Pharmaceuticals, vol. 15, (no. 7), 2022. | Journal Article
 
Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors. Pharmaceuticals
2021
A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects
Chakraborty, Soumen⋅DiBerto, Jeffrey F.⋅Faouzi, Abdelfattah⋅Bernhard, Sarah M.⋅Gutridge, Anna M.⋅Ramsey, Steven⋅Zhou, Yuchen⋅Provasi, Davide⋅Nuthikattu, Nitin⋅Jilakara, Rahul⋅Nelson, Melissa N.F.⋅Asher, Wesley B.⋅Eans, Shainnel O.⋅Wilson, Lisa L.⋅Chintala, Satyanarayana M⋅Filizola, Marta⋅Rijn, Richard M.⋅Margolis, Elyssa B.⋅Roth, Bryan L.⋅Mc Laughlin, Jay P.⋅Che, Tao⋅Sames, Dalibor⋅Javitch, Jonathan A. and Majumdar, Susruta
Cold Spring Harbor Laboratory
 
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects
Chakraborty, Soumen⋅DiBerto, Jeffrey F.⋅Faouzi, Abdelfattah⋅Bernhard, Sarah M.⋅Gutridge, Anna M.⋅Ramsey, Steven⋅Zhou, Yuchen⋅Provasi, Davide⋅Nuthikattu, Nitin⋅Jilakara, Rahul⋅Nelson, Melissa N. F.⋅Asher, Wesley B.⋅Eans, Shainnel O.⋅Wilson, Lisa L.⋅Chintala, Satyanarayana M.⋅Filizola, Marta⋅Rijn, Richard M.⋅Margolis, Elyssa B.⋅Roth, Bryan L.⋅Mc Laughlin, Jay P.⋅Che, Tao⋅Sames, Dalibor⋅Javitch, Jonathan A. and Majumdar, Susruta
pp. 13873–13892. | Journal Article
 
Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa
Ganzen, Logan⋅Logan, Ganzen⋅Jung, Ko M⋅Ko, Mee Jung⋅Zhang, Mengrui⋅Xie, Rui⋅Chen, Yongkai⋅Zhang, Liyun⋅Zhang, Liyun⋅James, Rebecca⋅James, Rebecca⋅Mumm, Jeff⋅Mumm, Jeff⋅Rijn, Richard M.⋅Zhong, Wenxuan⋅Pang, Chi P⋅Pang, Chi Pui⋅Zhang, Mingzhi⋅Zhang, Mingzhi⋅Tsujikawa, Motokazu⋅Leung, Yuk Fai and Leung, Yuk F
Scientific Reports, vol. 11. | Journal Article
 
Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose.
Sharifi, Farrokh⋅Sharifi, Farrokh⋅Meqbil, Yazan J.⋅Meqbil, Yazan J⋅Otte, Andrew⋅Otte, Andrew⋅Gutridge, Anna M.⋅Gutridge, Anna M⋅Blaine, Arryn T.⋅Blaine, Arryn T⋅van Rijn, Richard M.⋅van Rijn, Richard M⋅Park, Kinam and Park, Kinam
Pharmaceutical research. | Journal Article
 
Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder
Gutridge, Anna M.⋅Chakraborty, Soumen⋅Varga, Balazs R.⋅Rhoda, Elizabeth S.⋅French, Alexander R.⋅Blaine, Arryn T.⋅Royer, Quinten H.⋅Cui, Haoyue⋅Yuan, Jinling⋅Cassell, Robert J.⋅Szabó, Márk⋅Majumdar, Susruta and Rijn, Richard M.
Frontiers in Pharmacology, vol. 12. | Journal Article
 
Identification of a Novel Delta Opioid Receptor Agonist Chemotype with Potential Negative Allosteric Modulator Capabilities
Molecules. | Journal Article
 
Modulating \upbeta-Arrestin-2 Recruitment at the \updelta- and \upmu-Opioid Receptors Using Peptidomimetic Ligands
Sharma, Krishna Kumar⋅Sharma, Krishna K.⋅Cassell, Robert J.⋅Cassell, Robert J.⋅Meqbil, Yazan J.⋅Meqbil, Yazan J.⋅Su, HongYu⋅Su, Hongyu⋅Blaine, Arryn⋅Blaine, Arryn T.⋅Cummins, Benjamin R.⋅Cummins, Benjamin R.⋅Mores, Kendall⋅Mores, Kendall L.⋅Johnson, David K.⋅Johnson, David K.⋅Rijn, Richard M.⋅Rijn, Richard⋅Altman, Ryan A and Altman, Ryan A.
RSC Medicinal Chemistry. | Journal Article
 
β-Arrestin–dependent ERK signaling reduces anxiety-like and conditioned fear–related behaviors in mice
Ko, Mee Jung⋅Chiang, Terrance⋅Mukadam, Arbaaz A⋅Mulia, Grace E⋅Gutridge, Anna M⋅Lin, Angel⋅Chester, Julia A and van Rijn, Richard M
Science Signaling. | Journal Article
2020
A non‐convulsant delta‐opioid receptor agonist, KNT‐127, reduces cortical spreading depression and nitroglycerin‐induced allodynia
Headache: The Journal of Head and Face Pain. | Journal Article
 
Drug Screening with Zebrafish Visual Behavior Identifies Carvedilol as a Potential Treatment for Retinitis Pigmentosa
Ganzen, Logan⋅Ko, Mee Jung⋅Zhang, Mengrui⋅Xie, Rui⋅Chen, Yongkai⋅Zhang, Liyun⋅James, Rebecca⋅Mumm, Jeff⋅Rijn, Richard⋅Zhong, Wenxuan⋅Pang, Chi Pui⋅Zhang, Mingzhi⋅Tsujikawa, Motokazu and Leung, Yuk Fai
Cold Spring Harbor Laboratory
 
G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder
Gutridge, Anna M.⋅Robins, Meridith T.⋅Cassell, Robert J.⋅Uprety, Rajendra⋅Mores, Kendall L.⋅Ko, Mee Jung⋅Pasternak, Gavril W.⋅Majumdar, Susruta and Rijn, Richard M.
British Journal of Pharmacology. | Journal Article
 
Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids
Creed, Simone M.⋅Gutridge, Anna M.⋅Argade, Malaika D.⋅Hennessy, Madeline R.⋅Friesen, J. Brent⋅Pauli, Guido F.⋅Rijn, Richard M. and Riley, Andrew P.
Journal of Natural Products. | Journal Article
 
Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids
Creed, Simone⋅Gutridge, Anna⋅Argade, Malaika⋅Hennessy, Madeline⋅Friesen, J. Brent⋅Pauli, Guido⋅Rijn, Richard and Riley, Andrew
American Chemical Society (ACS)
 
Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids
Creed, Simone⋅Gutridge, Anna⋅Argade, Malaika⋅Hennessy, Madeline⋅Friesen, J. Brent⋅Pauli, Guido⋅Rijn, Richard and Riley, Andrew