59 Publications (Page 1 of 3)
2023
Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats
Tinsley, H.N.⋅Mathew, B.⋅Chen, X.⋅Maxuitenko, Y.Y.⋅Li, N.⋅Lowe, W.M.⋅Whitt, J.D.⋅Zhang, W.⋅Gary, B.D.⋅Keeton, A.B.⋅Grizzle, W.E.⋅Grubbs, C.J.⋅Reynolds, R.C. and Piazza, G.A.
Cancers, vol. 15. | Journal Article
2022
Pan-RAS inhibitors: Hitting multiple RAS isozymes with one stone
Coley, Alexander B⋅Coley, A.B.⋅Coley, AB⋅Ward, A⋅Ward, A.⋅Ward, Antonio⋅Keeton, AB⋅Keeton, Adam B⋅Keeton, A.B.⋅Chen, X⋅Chen, X.⋅Chen, Xi⋅Maxuitenko, Y.⋅Maxuitenko, Yulia⋅Maxuitenko, Y⋅Prakash, Aishwarya⋅Prakash, A.⋅Prakash, A⋅Li, F.⋅Li, Feng⋅Li, F⋅Foote, Jeremy B⋅Foote, J.B.⋅Foote, JB⋅Buchsbaum, Donald J⋅Buchsbaum, D.J.⋅Buchsbaum, Dj⋅Piazza, G.A.⋅Piazza, GA and Piazza, Gary A
(pp. 131-168)
 
Phosphodiesterase 10A (PDE10A) as a novel target to suppress ?-catenin and RAS signaling in epithelial ovarian cancer
Borneman, R.M.⋅Gavin, E.⋅Musiyenko, A.⋅Richter, W.⋅Lee, K.J.⋅Crossman, D.K.⋅Andrews, J.F.⋅Wilhite, A.M.⋅McClellan, S.⋅Aragon, I.⋅Ward, A.B.⋅Chen, X.⋅Keeton, A.B.⋅Berry, K.⋅Piazza, G.A.⋅Scalici, J.M. and Silva, L.M.
Journal of Ovarian Research, vol. 15. | Journal Article
 
The path to the clinic: a comprehensive review on direct KRASG12C inhibitors. Journal of Experimental & Clinical Cancer Research
2021
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity
Abdel-Halim, M.⋅Sigler, S.⋅Racheed, N.A.S.⋅Hefnawy, A.⋅Fathalla, R.K.⋅Hammam, M.A.⋅Maher, A.⋅Maxuitenko, Y.⋅Keeton, A.B.⋅Hartmann, R.W.⋅Engel, M.⋅Piazza, G.A. and Abadi, A.H.
Journal of Medicinal Chemistry, vol. 64, pp. 4462-4477. | Journal Article
 
Novel thiazolidine derivatives as potent selective pro-apoptotic agents
Hafez, D.E.⋅Eddiasty, I.⋅Shih, S.-P.⋅Chien, L.-C.⋅Hong, Y.-J.⋅Lin, H.-Y.⋅Keeton, A.B.⋅Piazza, G.A.⋅Abdel-Halim, M. and Abadi, A.H.
Bioorganic Chemistry, vol. 114. | Journal Article
 
Suppression of colon tumorigenesis in mutant apc mice by a novel PDE10 inhibitor that reduces oncogenic ?-catenin
Lee, K.J.⋅Chang, W.-C.L.⋅Chen, X.⋅Valiyaveettil, J.⋅Ramirez-Alcantara, V.⋅Gavin, E.⋅Musiyenko, A.⋅Da Silva, L.M.⋅Annamdevula, N.S.⋅Leavesley, S.J.⋅Ward, A.⋅Mattox, T.⋅Lindsey, A.S.⋅Andrews, J.⋅Zhu, B.⋅Wood, C.⋅Neese, A.⋅Nguyen, A.⋅Berry, K.⋅Maxuitenko, Y.⋅Moyer, M.P.⋅Nurmemmedov, E.⋅Gorman, G.⋅Coward, L.⋅Zhou, G.⋅Keeton, A.B.⋅Cooper, H.S.⋅Clapper, M.L. and Piazza, G.A.
Cancer Prevention Research, vol. 14, pp. 995-1008. | Journal Article
2020
Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors
Abdel-Halim, M.⋅Tinsley, H.⋅Keeton, A.B.⋅Weam, M.⋅Atta, N.H.⋅Hammam, M.A.⋅Hefnawy, A.⋅Hartmann, R.W.⋅Engel, M.⋅Piazza, G.A. and Abadi, A.H.
Bioorganic Chemistry, vol. 104. | Journal Article
 
Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS
Ward, AB⋅Keeton, Ab⋅Chen, X⋅Mattox, TE⋅Coley, AB⋅Maxuitenko, YY⋅Buchsbaum, Dj⋅Randall, TD⋅Zhou, G and Piazza, GA
MedComm, vol. 1, pp. 121–128. | Journal Article
 
Exploiting RAS nucleotide cycling as a strategy for drugging RAS-driven cancers
Mattox, T.E.⋅Chen, X.⋅Maxuitenko, Y.Y.⋅Keeton, A.B. and Piazza, G.A.
International Journal of Molecular Sciences, vol. 21. | Journal Article
 
Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors
ElHady, A.K.⋅Shih, S.-P.⋅Chen, Y.-C.⋅Liu, Y.-C.⋅Ahmed, N.S.⋅Keeton, A.B.⋅Piazza, G.A.⋅Engel, M.⋅Abadi, A.H. and Abdel-Halim, M.
Bioorganic Chemistry, vol. 98. | Journal Article
 
Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy
Emmanouilidi, A⋅Casari, I⋅Akkaya, BG⋅Maffucci, T⋅Furic, L⋅Guffanti, F⋅Broggini, M⋅Chen, X⋅Maxuitenko, YY⋅Keeton, Ab⋅Piazza, GA⋅Linton, KJ and Falasca, M
CANCERS, vol. 12. | Journal Article
 
New isatin?indole conjugates: Synthesis, characterization, and a plausible mechanism of their in vitro antiproliferative activity
Al-Wabli, R.I.⋅Almomen, A.A.⋅Almutairi, M.S.⋅Keeton, A.B.⋅Piazza, G.A. and Attia, M.I.
Drug Design, Development and Therapy, vol. 14, pp. 483-495. | Journal Article
 
PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity. Drug Discovery Today
Piazza, Gary A.⋅Ward, Antonio⋅Chen, Xi⋅Maxuitenko, Yulia⋅Coley, Alex⋅Aboelella, Nada S.⋅Buchsbaum, Donald J.⋅Boyd, Michael R.⋅Keeton, Adam B. and Zhou, Gang
 
Quinazolinone-schiff’s base hybrids as phosphodiesterase 4b inhibitors with dual activity against COPD and lung cancer
Mansour, M.A.⋅El-Saadi, M.T.⋅Amin, N.H.⋅Canzoneri, J.C.⋅Keeton, A.B.⋅Piazza, G.A. and Abdel-Rahman, H.M.
Egyptian Journal of Chemistry, vol. 63, pp. 4851-4866. | Journal Article
 
Targeting cGMP/PKG signaling for the treatment or prevention of colorectal cancer with novel sulindac derivatives lacking cyclooxygenase inhibitory activity. Oncology Signaling
Piazza, GA⋅Chen, X⋅Ward, A⋅Coley, A⋅Zhou, G⋅Buchsbaum, Dj and Maxuitenko, Y
2019
Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins
Almutairi, M.S.⋅Hassan, E.S.⋅Keeton, A.B.⋅Piazza, G.A.⋅Abdelhameed, A.S. and Attia, M.I.
Drug Design, Development and Therapy, vol. 13, pp. 3069-3078. | Journal Article
 
Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity
Abd El-Aleam, R.H.⋅George, R.F.⋅Lee, K.J.⋅Keeton, A.B.⋅Piazza, G.A.⋅Kamel, A.A.⋅El-Daly, M.E.⋅Hassan, G.S. and Abdel-Rahman, H.M.
Archiv der Pharmazie, vol. 352. | Journal Article
 
Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer
Adamska, A.⋅Domenichini, A.⋅Capone, E.⋅Damiani, V.⋅Akkaya, B.G.⋅Linton, K.J.⋅Di Sebastiano, P.⋅Chen, X.⋅Keeton, A.B.⋅Ramirez-Alcantara, V.⋅Maxuitenko, Y.⋅Piazza, G.A.⋅De Laurenzi, V.⋅Sala, G. and Falasca, M.
Journal of Experimental and Clinical Cancer Research, vol. 38. | Journal Article
2018
Synthesis and biological evaluation of certain hydrazonoindolin-2-one derivatives as new potent anti-proliferative agents
Eldehna, W.M.⋅Al-Wabli, R.I.⋅Almutairi, M.S.⋅Keeton, A.B.⋅Piazza, G.A.⋅Abdel-Aziz, H.A. and Attia, M.I.
Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 33, pp. 867-878. | Journal Article
2017
Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
Abdel-Aziz, Hatem A⋅Abdel-Aziz, Hatem A⋅Eldehna, Wagdy M⋅Eldehna, Wagdy M⋅Keeton, Adam B⋅Keeton, Adam B⋅Piazza, Gary A⋅Piazza, Gary A⋅Kadi, Adnan A⋅Kadi, Adnan A⋅Attwa, Mohamed W⋅Attwa, Mohamed W⋅Abdelhameed, Ali S⋅Abdelhameed, Ali S⋅Attia, Mohamed I and Attia, Mohamed I
Drug Design, Development and Therapy, vol. 11, pp. 2333-2346, 2017. | Journal Article
 
New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres
Attia, Mohamed I⋅Attia, Mohamed I⋅Eldehna, Wagdy M⋅Eldehna, Wagdy M⋅Afifi, Samar A⋅Afifi, Samar A⋅Keeton, Adam B⋅Keeton, Adam B⋅Piazza, Gary A⋅Piazza, Gary A⋅Abdel-Aziz, Hatem A and Abdel-Aziz, Hatem A
PLoS One, vol. 12, (no. 7), Jul 2017. | Journal Article
 
Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking ?-catenin and MAPK signaling
Zhu, B.⋅Lindsey, A.⋅Li, N.⋅Lee, K.⋅Ramirez-Alcantara, V.⋅Canzoneri, J.C.⋅Fajardo, A.⋅Silva, L.M.⋅Thomas, M.⋅Piazza, J.T.⋅Yet, L.⋅Eberhardt, B.T.⋅Gurpinar, E.⋅Otali, D.⋅Grizzle, W.⋅Valiyaveettil, J.⋅Chen, X. and Keeton, A.B.
Oncotarget, vol. 8, pp. 69264-69280. | Journal Article
 
Search for Inhibitors of Ras-Driven Cancers
Keeton, A.B. and Piazza, G.A.
(pp. 135-154)
 
The RAS-effector interaction as a drug target
Keeton, A.B.⋅Salter, E.A. and Piazza, G.A.
Cancer Research, vol. 77, pp. 221-226. | Journal Article