59 Publications (Page 2 of 3)
2016
?-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG
Lee, K.⋅Lindsey, A.S.⋅Li, N.⋅Gary, B.⋅Andrews, J.⋅Keeton, A.B. and Piazza, G.A.
Oncotarget, vol. 7, pp. 5353-5365. | Journal Article
 
Increasing the endoplasmic reticulum pool of the F508del allele of the cystic fibrosis transmembrane conductance regulator leads to greater folding correction by small molecule therapeutics
Chung, W⋅Chung, W J⋅Chung, W.J.⋅Goeckeler-Fried, Jennifer L⋅Goeckeler-Fried, Jennifer⋅Goeckeler-Fried, J.L.⋅Havasi, Viktoria⋅Havasi, Viktoria⋅Havasi, V.⋅Chiang, Annette⋅Chiang, Annette⋅Chiang, A.⋅Rowe, S.M.⋅Rowe, Steven⋅Rowe, Steven M⋅Plyler, Zackery E⋅Plyler, Zackery⋅Plyler, Z.E.⋅Hong, Jeong S⋅Hong, Jeong⋅Hong, J.S.⋅Mazur, M.⋅Mazur, Marina⋅Mazur, Marina⋅Piazza, G.A.⋅Piazza, Gary A⋅Piazza, Gary⋅Keeton, Adam⋅Keeton, A.B.⋅Keeton, Adam B⋅White, E.L.⋅White, E⋅White, E L⋅Rasmussen, Lynn⋅Rasmussen, L.⋅Rasmussen, Lynn⋅Weissman, A.M.⋅Weissman, Allan⋅Weissman, Allan M⋅Denny, R⋅Brodsky, Jeffrey L⋅Brodsky, J.L.⋅Brodsky, Jeffrey and Sorscher, Eric J
PLoS ONE, vol. 11. | Journal Article
 
Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells
Prasain, J.K.⋅Rajbhandari, R.⋅Keeton, A.B.⋅Piazza, G.A. and Barnes, S.
Food and Function, vol. 7, pp. 4012-4019. | Journal Article
 
Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion.
Whitt, Jason D⋅Keeton, Adam B⋅Gary, Bernard D⋅Sklar, Larry A⋅Sodani, Kamlesh⋅Chen, Zhe-Sheng and Piazza, Gary A
Journal of biomedical research, vol. 30, (no. 2), pp. 120-133, March 2016. | Journal Article
 
Synthesis and Optimization of New 3,6-Disubstitutedindole Derivatives and Their Evaluation as Anticancer Agents Targeting the MDM2/MDMx Complex
Rezk, Mohamed Salah⋅Abdel-Halim, Mohammad⋅Keeton, Adam⋅Franklin, Derek⋅Bauer, Matthias⋅Boeckler, Frank Michael⋅Engel, Matthias⋅Hartmann, Rolf Wolfgang⋅Zhang, Yanping⋅Piazza, Gary Anthony and Abadi, Ashraf Hassan
Chemical and Pharmaceutical Bulletin, vol. 64, (no. 1), pp. 41, 2016. | Journal Article
2015
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.
Li, N⋅Lee, K⋅Xi, Y⋅Zhu, B⋅Gary, B D⋅Ramírez-Alcántara, V⋅Gurpinar, E⋅Canzoneri, J C⋅Fajardo, A⋅Sigler, S⋅Piazza, J T⋅Chen, X⋅Andrews, J⋅Thomas, M⋅Lu, W⋅Li, Y⋅Laan, D J⋅Moyer, M P⋅Russo, S⋅Eberhardt, B T⋅Yet, L⋅Keeton, A B⋅Grizzle, W E and Piazza, G A
Oncogene, vol. 34, (no. 12), pp. 1499-1509, March 19, 2015. | Journal Article
 
Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.
Li, Nan⋅Chen, Xi⋅Zhu, Bing⋅Ramírez-Alcántara, Verónica⋅Canzoneri, Joshua C⋅Lee, Kevin⋅Sigler, Sara⋅Gary, Bernard⋅Li, Yonghe⋅Zhang, Wei⋅Moyer, Mary P⋅Salter, E Alan⋅Wierzbicki, Andrzej⋅Keeton, Adam B and Piazza, Gary A
Oncotarget, vol. 6, (no. 29), pp. 27403-27415, September 29, 2015. | Journal Article
2014
Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention
Aboul-Fadl, T.⋅Al-Hamad, S.S.⋅Lee, K.⋅Li, N.⋅Gary, B.D.⋅Keeton, A.B.⋅Piazza, G.A. and Abdel-Hamid, M.K.
Medicinal Chemistry Research, vol. 23, pp. 4177-4188. | Journal Article
2013
6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.
Hamed, Mostafa M⋅AbouElElla, D.A.⋅Abou El Ella, Dalal A⋅Keeton, Adam B⋅Piazza, Gary A⋅Abadi, Ashraf H⋅Hartmann, Rolf W and Engel, Matthias
ChemMedChem, vol. 8, (no. 9), pp. 1495-1504, September 2013. | Journal Article
 
A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.
Gurpinar, Evrim⋅Grizzle, William E⋅Shacka, John⋅Mader, Burton J⋅Li, Nan⋅Piazza, Nicholas A⋅Russo, Suzanne⋅Keeton, Adam B and Piazza, Gary A
Molecular cancer therapeutics, vol. 12, (no. 5), pp. 663-74, 2013/May. | Journal Article
 
New NSAID targets and derivatives for colorectal cancer chemoprevention
Tinsley, H.N.⋅Grizzle, W.E.⋅Abadi, A.⋅Keeton, A.⋅Zhu, B.⋅Xi, Y. and Piazza, G.A.
(pp. 105-120)
 
Quinazoline and tetrahydropyridothieno[2,3-d]pyrimidine derivatives as irreversible EGFR tyrosine kinase inhibitors: Influence of the position 4 substituent
Hamed, M.M.⋅Abou El Ella, D.A.⋅Keeton, A.B.⋅Piazza, G.A.⋅Engel, M.⋅Hartmann, R.W. and Abadi, A.H.
MedChemComm, vol. 4, pp. 1202-1207. | Journal Article
 
Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
Li, Nan⋅Xi, Yaguang⋅Tinsley, Heather N⋅Gurpinar, Evrim⋅Gary, Bernard D⋅Zhu, Bing⋅Li, Yonghe⋅Chen, Xi⋅Keeton, Adam B⋅Abadi, Ashraf H⋅Moyer, Mary P⋅Grizzle, William E⋅Chang, Wen-Chi⋅Clapper, Margie L and Piazza, Gary A
Molecular cancer therapeutics, vol. 12, (no. 9), pp. 1848-59, 2013/Sep. | Journal Article
 
Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity
Awadallah, F.M.⋅Piazza, G.A.⋅Gary, B.D.⋅Keeton, A.B. and Canzoneri, J.C.
European Journal of Medicinal Chemistry, vol. 70, pp. 273-279. | Journal Article
 
Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53
Abdel-Halim, M.⋅Keeton, A.B.⋅Gurpinar, E.⋅Gary, B.D.⋅Vogel, S.M.⋅Engel, M.⋅Piazza, G.A.⋅Boeckler, F.M.⋅Hartmann, R.W. and Abadi, A.H.
Bioorganic and Medicinal Chemistry, vol. 21, pp. 7343-7356. | Journal Article
2012
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
Whitt, Jason D⋅Li, Nan⋅Tinsley, Heather N⋅Chen, Xi⋅Zhang, Wei⋅Li, Yonghe⋅Gary, Bernard D⋅Keeton, Adam B⋅Xi, Yaguang⋅Abadi, Ashraf H⋅Grizzle, William E and Piazza, Gary A
Cancer prevention research (Philadelphia, Pa.), vol. 5, (no. 6), pp. 822-833, June 2012. | Journal Article
2011
A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells.
Li, Hui-Fang⋅Keeton, Adam⋅Vitolo, Michele I⋅Maddox, Clinton⋅Rasmussen, Lynn⋅Hobrath, Judith⋅Lucille White, E.⋅White, E L⋅Park, Ben H⋅Piazza, Gary A⋅Kim, Jung-Sik and Waldman, Todd
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening, vol. 16, (no. 4), pp. 383-93, 2011/Apr. | Journal Article
 
Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.
Tinsley, Heather N⋅Gary, Bernard D⋅Keeton, Adam B⋅Lu, Wenyan⋅Li, Yonghe and Piazza, Gary A
Cancer prevention research (Philadelphia, Pa.), vol. 4, (no. 8), pp. 1275-1284, August 2011. | Journal Article
2010
Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.
Tinsley, Heather N⋅Gary, Bernard D⋅Thaiparambil, Jose⋅Li, Nan⋅Lu, Wenyan⋅Li, Yonghe⋅Maxuitenko, Yulia Y⋅Keeton, Adam B and Piazza, Gary A
Cancer prevention research (Philadelphia, Pa.), vol. 3, (no. 10), pp. 1303-1313, October 2010. | Journal Article
 
NSAIDs: Old Drugs Reveal New Anticancer Targets
Piazza, Gary A⋅Keeton, Adam B⋅Tinsley, Heather N⋅Whitt, Jason D⋅Gary, Bernard D⋅Mathew, Bini⋅Singh, Raj⋅Grizzle, William E and Reynolds, Robert C
(pp. 1652-1667). 2010
2009
A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.
Piazza, Gary A⋅Keeton, Adam B⋅Tinsley, Heather N⋅Gary, Bernard D⋅Whitt, Jason D⋅Mathew, Bini⋅Thaiparambil, Jose⋅Coward, Lori⋅Gorman, Gregory⋅Li, Yonghe⋅Sani, Brahma⋅Hobrath, Judith V⋅Maxuitenko, Yulia Y and Reynolds, Robert C
Cancer prevention research (Philadelphia, Pa.), vol. 2, (no. 6), pp. 572-580, June 2009. | Journal Article
 
Assay for isolation of inhibitors of her2-kinase expression.
Chiosis, Gabriela and Keeton, Adam B
Methods in molecular biology (Clifton, N.J.), vol. 486, pp. 139-49, 2009. | Journal Article
 
Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G
Tinsley, H.N.⋅Gary, B.D.⋅Keeton, A.B.⋅Zhang, W.⋅Abadi, A.H.⋅Reynolds, R.C. and Piazza, G.A.
Molecular Cancer Therapeutics, vol. 8, pp. 3331-3340. | Journal Article
 
Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation.
Lu, Wenyan⋅Tinsley, Heather N⋅Keeton, Adam⋅Qu, Zhican⋅Piazza, Gary A and Li, Yonghe
European journal of pharmacology, vol. 602, (no. 1), pp. 8-14, January 5, 2009. | Journal Article
 
Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents
Abadi, A.H.⋅Abouel-Ella, D.A.⋅Ahmed, N.S.⋅Gary, B.D.⋅Thaiparambil, J.T.⋅Tinsley, H.N.⋅Keeton, A.B. and Piazza, G.A.
Arzneimittel-Forschung/Drug Research, vol. 59, pp. 415-421. | Journal Article