The central theme of our scholarly work over the past several decades has been synthesis and assessment of structural and stereochemical isomerism in synthetic NPS drugs.

In recent years we have expanded our research efforts in collaboration with pharmacology colleagues to include basic receptor pharmacology of the novel drugs we have synthesized, as well as investigation of their potential mechanisms of neurotoxicity.


  • Design, synthesis and biochemical evaluation of enzyme inhibitors; synthesis and chemical reactivity of potential chemotherapeutic agents; synthesis of novel heterocycles as potential medicinal agents.


  • Design, Synthesis and Biochemical Actions of Aldose Reductase Inhibitors
  • Design and Synthesis of Novel Ligands for the Opiate Receptor
  • Stereochemical Aspects of Drug Synthesis and Drug-Target Interactions
  • Synthesis, Methods of Analysis and Pharmacology of Drugs of Abuse
  • Design and Synthesis of Inhibitors of Aldose Reductase
  • Publications: J. Med. Chem., J. Heterocyclic Chem., J. Chromatogr. Sci


PhD, Virginia Commonwealth University, Medicinal Chemistry, 1982
MS, University of Michigan, Medicinal Chemistry, 1978
BS, Hope College, Chemistry, 1976
pharmacy & pharmacology
Alabama Academy of Science
American Chemical Society