Dr. Griffett’s research interests focus on characterizing novel compounds targeting nuclear receptors that can be optimized and further developed for therapeutics.

Research Interests

  • Nuclear Receptors, Chemical Biology, Cardiometabolic Diseases, Pain, NAFLD/NASH

Academic Areas

  • Physiology, Pharmacology

Key Words

  • Nuclear Receptors, Drug Discovery, Metabolic Disease, Chronic Inflammation, Pain

My work focuses on nuclear receptor pharmacology and physiology, and the development of novel therapeutics for cardio-metabolic, inflammatory, and related diseases.

Research: Investigating the role of nuclear receptors in cardio-metabolic diseases, diabetes complications, cancer, and inflammatory pain to develop novel tools and therapeutics.

Our main research focus is on Nuclear Receptor Pharmacology and Drug Discovery.

The focus of the Griffett lab is to elucidate the role of various nuclear hormone receptors in physiology and disease, and discover novel chemical probes that may provide insight into future therapeutics.

Research Interests

  • Discovering Novel Therapeutics for NAFLD, NASH, and Metabolic Diseases
  • Developing Non-Opioid Therapeutics for Chronic Pain Conditions
  • Circadian Regulation of Pain
  • Future Research Plans: Chemical-Biology Approaches to Developing Small Molecule Probes for Nuclear Receptors
Past Affiliations

PhD Student, Department of Cell Biology, Microbiology and Molecular Biology, School of Natural Sciences and Mathematics, College of Arts and Sciences, University of South Florida (past)

Postdoc, Department of Molecular Medicine, Scripps Research Institute (past)

Postdoctoral Fellow, Department of Pharmacological and Physiological Science, School of Medicine, Saint Louis University (past)

Research Assistant Professor, Department of Pharmacological and Physiological Science, School of Medicine, Saint Louis University (past)

Assistant Professor, Center for Clinical Pharmacology, Washington University in St. Louis (past)

Pharmacology, Physiology, Human Anatomy
PhD, University of South Florida, 2011
MS, Long Island University Brooklyn Campus, 2006
BS, St. Joseph’s College, 2004