22 Publications
2017
Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
Abdel-Aziz, Hatem A⋅Abdel-Aziz, Hatem A⋅Eldehna, Wagdy M⋅Eldehna, Wagdy M⋅Keeton, Adam B⋅Keeton, Adam B⋅Piazza, Gary A⋅Piazza, Gary A⋅Kadi, Adnan A⋅Kadi, Adnan A⋅Attwa, Mohamed W⋅Attwa, Mohamed W⋅Abdelhameed, Ali S⋅Abdelhameed, Ali S⋅Attia, Mohamed I and Attia, Mohamed I
Drug Design, Development and Therapy, vol. 11, pp. 2333-2346, 2017. | Journal Article
 
New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres
Attia, Mohamed I⋅Attia, Mohamed I⋅Eldehna, Wagdy M⋅Eldehna, Wagdy M⋅Afifi, Samar A⋅Afifi, Samar A⋅Keeton, Adam B⋅Keeton, Adam B⋅Piazza, Gary A⋅Piazza, Gary A⋅Abdel-Aziz, Hatem A and Abdel-Aziz, Hatem A
PLoS One, vol. 12, (no. 7), Jul 2017. | Journal Article
2015
Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity.
Li, N⋅Lee, K⋅Xi, Y⋅Zhu, B⋅Gary, B D⋅Ramírez-Alcántara, V⋅Gurpinar, E⋅Canzoneri, J C⋅Fajardo, A⋅Sigler, S⋅Piazza, J T⋅Chen, X⋅Andrews, J⋅Thomas, M⋅Lu, W⋅Li, Y⋅Laan, D J⋅Moyer, M P⋅Russo, S⋅Eberhardt, B T⋅Yet, L⋅Keeton, A B⋅Grizzle, W E and Piazza, G A
Oncogene, vol. 34, (no. 12), pp. 1499-1509, March 19, 2015. | Journal Article
 
Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10.
Li, Nan⋅Chen, Xi⋅Zhu, Bing⋅Ramírez-Alcántara, Verónica⋅Canzoneri, Joshua C⋅Lee, Kevin⋅Sigler, Sara⋅Gary, Bernard⋅Li, Yonghe⋅Zhang, Wei⋅Moyer, Mary P⋅Salter, E Alan⋅Wierzbicki, Andrzej⋅Keeton, Adam B and Piazza, Gary A
Oncotarget, vol. 6, (no. 29), pp. 27403-27415, September 29, 2015. | Journal Article
2014
NSAIDs inhibit tumorigenesis, but how?
Gurpinar, Evrim⋅Grizzle, William E and Piazza, Gary A
Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 20, (no. 5), pp. 1104-1113, March 1, 2014. | Journal Article
 
The role of cyclic nucleotide signaling pathways in cancer: targets for prevention and treatment.
Fajardo, Alexandra M⋅Piazza, Gary A and Tinsley, Heather N
Cancers, vol. 6, (no. 1), pp. 436-458, February 26, 2014. | Journal Article
2013
6-Aryl and heterocycle quinazoline derivatives as potent EGFR inhibitors with improved activity toward gefitinib-sensitive and -resistant tumor cell lines.
Hamed, Mostafa M⋅AbouElElla, D.A.⋅Abou El Ella, Dalal A⋅Keeton, Adam B⋅Piazza, Gary A⋅Abadi, Ashraf H⋅Hartmann, Rolf W and Engel, Matthias
ChemMedChem, vol. 8, (no. 9), pp. 1495-1504, September 2013. | Journal Article
 
Hypoxia-regulated microRNAs in human cancer
Shen, Guomin⋅Shen, Guomin⋅Li, Xiaobo⋅Li, Xiaobo⋅Jia, Yong-feng⋅Jia, Yong-feng⋅Piazza, Gary A⋅Piazza, Gary A⋅Xi, Yaguang and Xi, Yaguang
Acta Pharmacologica Sinica, vol. 34, (no. 3), pp. 336-41, Mar 2013. | Journal Article
 
MicroRNA and cancer chemoprevention.
Yi, Bin⋅Piazza, Gary A⋅Su, Xiulan and Xi, Yaguang
Cancer prevention research (Philadelphia, Pa.), vol. 6, (no. 5), pp. 401-409, May 2013. | Journal Article
 
MicroRNAs are involved in the self-renewal and differentiation of cancer stem cells
Wang, Zheng-ming⋅Wang, Zheng-ming⋅Du, Wen-jun⋅Du, Wen-jun⋅Piazza, Gary A⋅Piazza, Gary A⋅Xi, Yaguang and Xi, Yaguang
Acta Pharmacologica Sinica, vol. 34, (no. 11), pp. 1374-80, Nov 2013. | Journal Article
 
Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling.
Li, Nan⋅Xi, Yaguang⋅Tinsley, Heather N⋅Gurpinar, Evrim⋅Gary, Bernard D⋅Zhu, Bing⋅Li, Yonghe⋅Chen, Xi⋅Keeton, Adam B⋅Abadi, Ashraf H⋅Moyer, Mary P⋅Grizzle, William E⋅Chang, Wen-Chi⋅Clapper, Margie L and Piazza, Gary A
Molecular cancer therapeutics, vol. 12, (no. 9), pp. 1848-59, 2013/Sep. | Journal Article
2012
A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.
Whitt, Jason D⋅Li, Nan⋅Tinsley, Heather N⋅Chen, Xi⋅Zhang, Wei⋅Li, Yonghe⋅Gary, Bernard D⋅Keeton, Adam B⋅Xi, Yaguang⋅Abadi, Ashraf H⋅Grizzle, William E and Piazza, Gary A
Cancer prevention research (Philadelphia, Pa.), vol. 5, (no. 6), pp. 822-833, June 2012. | Journal Article
 
Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases.
Tinsley, Heather N and Piazza, Gary A
Current colorectal cancer reports, vol. 8, (no. 4), pp. 325-330, December 2012. | Journal Article
 
Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs.
Li, X⋅Li, X.⋅Gao, L.⋅Gao, L⋅Cui, Q.⋅Cui, Q⋅Gary, B D⋅Gary, B.D.⋅Dyess, D L⋅Dyess, D.L.⋅Taylor, W⋅Taylor, W.⋅Shevde, L.A.⋅Shevde, L A⋅Samant, R S⋅Samant, R.S.⋅Dean-Colomb, W⋅Dean-Colomb, W.⋅Piazza, G.A.⋅Piazza, G A⋅Xi, Y. and Xi, Y
Oncogene, vol. 31, (no. 48), pp. 4979-4986, November 29, 2012. | Journal Article
2011
Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.
Tinsley, Heather N⋅Gary, Bernard D⋅Keeton, Adam B⋅Lu, Wenyan⋅Li, Yonghe and Piazza, Gary A
Cancer prevention research (Philadelphia, Pa.), vol. 4, (no. 8), pp. 1275-1284, August 2011. | Journal Article
2010
Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.
Tinsley, Heather N⋅Gary, Bernard D⋅Thaiparambil, Jose⋅Li, Nan⋅Lu, Wenyan⋅Li, Yonghe⋅Maxuitenko, Yulia Y⋅Keeton, Adam B and Piazza, Gary A
Cancer prevention research (Philadelphia, Pa.), vol. 3, (no. 10), pp. 1303-1313, October 2010. | Journal Article
 
NSAIDs: Old Drugs Reveal New Anticancer Targets
Piazza, Gary A⋅Keeton, Adam B⋅Tinsley, Heather N⋅Whitt, Jason D⋅Gary, Bernard D⋅Mathew, Bini⋅Singh, Raj⋅Grizzle, William E and Reynolds, Robert C
(pp. 1652-1667). 2010
2009
A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.
Piazza, Gary A⋅Keeton, Adam B⋅Tinsley, Heather N⋅Gary, Bernard D⋅Whitt, Jason D⋅Mathew, Bini⋅Thaiparambil, Jose⋅Coward, Lori⋅Gorman, Gregory⋅Li, Yonghe⋅Sani, Brahma⋅Hobrath, Judith V⋅Maxuitenko, Yulia Y and Reynolds, Robert C
Cancer prevention research (Philadelphia, Pa.), vol. 2, (no. 6), pp. 572-580, June 2009. | Journal Article
 
Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation.
Lu, Wenyan⋅Tinsley, Heather N⋅Keeton, Adam⋅Qu, Zhican⋅Piazza, Gary A and Li, Yonghe
European journal of pharmacology, vol. 602, (no. 1), pp. 8-14, January 5, 2009. | Journal Article
2004
Nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors for prostate cancer chemoprevention.
Basler, Joseph W and Piazza, Gary A
The Journal of urology. , vol. 171, (no. 2 Pt 2), pp. S59-62; discussion S62-3, 2004/Feb. | Journal Article
1999
Sulindac sulfone induced regression of rectal polyps in patients with familial adenomatous polyposis.
Stoner, Gary D⋅Budd, G. T⋅Ganapathi, Ram⋅DeYoung, B⋅Deyoung, Barry R⋅Kresty, Laura A⋅Nitert, M⋅Fryer, B⋅Church, J M⋅Provencher, K⋅Pamukcu, R⋅Piazza, G⋅Hawk, E⋅Kelloff, G⋅Elson, P and van Stolk, R U
Advances in experimental medicine and biology, vol. 470, pp. 45-53, 1999. | Journal Article
1998
Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines
Han, Edward K⋅Arber, Nadir⋅Yamamoto, Hirofumi⋅Lim, Jin T⋅Delohery, Tom⋅Pamukcu, Rifat⋅Piazza, Gary A⋅Xing, Wang Q and Weinstein, I B
Breast Cancer Research and Treatment, vol. 48, (no. 3), pp. 195-203, Apr 1998. | Journal Article