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I have training in pharmacology and cancer research with an interest in cancer drug discovery and development. My research for the past 25 years has studied the molecular basis for the antineoplastic activity of nonsteroidal anti-inflammatory drugs (NSAIDs). My research in the pharmaceutical industry supported the preclinical development of the non-COX inhibitory sulfone metabolite of sulindac, exisulind, to treat precancerous adenomas in patients with familial adenomatous polyposis (FAP) that was advanced to Phase 3 clinical trials and showed promising efficacy but did not receive FDA approval due to hepatotoxicity.
Department Head, Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University 2021
W.W. Walker Professor, Department of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University 2021
Professor, Department of Pharmacology, Frederick P. Whiddon College of Medicine, University of South Alabama (past)
Professor, Mitchell Cancer Institute, University of South Alabama (past)