Research Areas: Biochemistry
Research and Teaching Interests:
- Biochemistry: Structure and function of heme-dependent enzymes
The common threads that join our research interests together are the topics of bacterial virulence, antibiotic resistance, and discovery of new leads for antibiotic development, most especially with respect to Mycobacterium tuberculosis. We have two enzyme systems on which we are particularly focused: 1) the multifunctional heme enzyme catalase-peroxidase known as KatG, and 2) shikimate kinase, an enzyme essential for the biosynthesis of aromatic compounds, most prominently the aromatic amino acids.
- Catalase-peroxidase (KatG)
- Shikimate Kinase
My primary area of research in the Marnett laboratory was the mechanisms of intramolecular electron transfer in prostaglandin H synthase.