- Comparative and functional genomics in animal health and diseases:
- Genomics and metagenomics on host-microbial interactions
- Assorted topics in evolutionary genomics
Keywords: Genomics; Epigenomics; Metagenomics; Evolution; Gene Expression
Dr. Wang's primary research area is multi-omics analysis of health, performance, production, welfare, and disease in companion and food animals, with emphasis from fundamental sciences to veterinary/agricultural applications. Wang laboratory uses next-generation sequencing technologies and comparative and functional genomic approaches to investigate animal genome, transcriptome, DNA methylome, and microbiome. They have analyzed allele-specific gene expression and allele-specific DNA methylation in mammalian placenta samples including marsupials, mouse, cattle, dog, and interspecific equid hybrids (mules and hinnies), and characterized different forms of X chromosome inactivation and their epigenetic regulation in the placenta. Wang lab also performs metagenomic analyses of human, cattle, cat, and chicken gut microbiota, to search for differential composition and abundance of gut microbes at normal and diseased conditions.