Specialty:
Research Interests:
- Vitamin B3 (Niacin) metabolism and its impact on disease management, treatment and prevention
- Cellular metabolism and its relevance to health through balanced and informed vitamin supplementation
- Novel chemical entities as putatives anti-cancer lead compounds
Over the past decade, Dr. Migaud’s laboratory has developed an extensive chemical biology program that focuses on vitamin B3 and its role in health and disease.
Her studies have opened the door to detailed analyses of a number of NAD metabolism processes and helped correlate how vitamin supplements impact health status and recovery following chemotherapy and radiotherapy treatment.
Synthetic organic chemist and chemical biologist with expertise in nucleoside, nucleotide, and dinucleotide chemistry and with focused interests on developing tools to probe vitamin Bs' chemical biology and its role in understanding diseases’ pathogenesis and pathophysiology.
My research interest resides in developing modular multidisciplinary strategies that seek to modulate the bioavailability of B-vitamin derived redox cofactors to interrogate biological systems while allowing the traceability of changes.
Areas of expertise:
- Organic Synthesis
- Organic Synthesis; Nucleoside, Nucleotides, Dinucleotides, Phosphate Chemistry; Ionic Liquids in Organic Chemistry; Mechanochemistry
- Chemical Biology
- Isotopic and Fluorescent Tracing; Metabolomics
- Drug Delivery
- Nanoparticle generation and characterization
- Oncological Chemical Biology
- Cell metabolism; Mitochondrial Dysfunction
- Micronutrition in cancer
- Metabolic and Signaling coenzymes (NAD; FAD; SAM; Acyl-CoA)-biosynthetic pathways in cancer
Current Projects:
- Biosynthesis and catabolism of riboflavin cofactors
- Catabolites of NAD(P) and their functions
- Ovarian and Breast Tumor Microenvironment from a micronutrionents’ perspective
- Novel precursors of redox and signaling cofactors.
