A part of my laboratory has been engaged with performing fundamental studies on the biochemistry and structural biology of base excision repair (BER) complexes involved in the repair of non-bulky lesions formed in mtDNA.
Furthermore, we are interested in three aspects of NEIL-enzyme regulation including (1) identifying the subcellular localization of NEIL enzymes in response to oxidative stress, (2) regulation of NEIL activity by post- translational modifications, and (3) structure-driven functional studies that seek to identify unique protein interacting partners of the NEIL enzymes, which are essential for successful repair.
