As part of the Center for Lung Biology team, we primarily focus on the mechanobiology of lungs. Several of our ongoing projects involve identifying the physical laws that govern migration, deformation, division, detachment and death of lung endothelial cells.
Research:
- Intercellular tractions revealed
- Moments of individual cells revealed
- Sprawling "subdivisions" and narrow "boundaries"
- Integrative Toolkit to Analyze Cellular Signals (iTACS)
- Neighbors shape cellular behavior forcefully
- Plithotaxis
- Rugged stress landscape with local tug-of-war
- Monolayer Stress Microscopy
- Barrier function as a collective phenomenon
Keywords: Cellular biomechanics, monolayer stress microscopy
Expertise:
- Physical laws governing the function of cells, tissues, and organs
- Mechanical characterization of cells, tissues, and organs
- Tools for life sciences researchers and healthcare providers
- Monolayer stress microscopy and monolayer mechanics
- Creativity-focused activities in engineering education
Expertise:
- Mechanical behavior of endothelial cells and their microenvironment in pulmonary venous hypertension