46 Publications (Page 1 of 2)
2013
Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death.
Theobald, Benjamin⋅Bonness, Kathy⋅Musiyenko, Alla⋅Andrews, Joel F⋅Urban, Gudrun⋅Huang, Xizhong⋅Dean, Nicholas M and Honkanen, Richard E
Molecular cancer research : MCR, vol. 11, (no. 8), pp. 845-55, 2013/Aug. | Journal Article
2011
Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity.
Yang, Xiulan⋅Liu, Yanping⋅Yang, Xi-Ming⋅Hu, Fangdi⋅Cui, Lin⋅Swingle, Mark R⋅Honkanen, Richard E⋅Soltani, Peyman⋅Tissier, Renaud⋅Cohen, Michael V and Downey, James M
Basic research in cardiology, vol. 106, (no. 3), pp. 421-30, 2011/May. | Journal Article
2010
Total synthesis and evaluation of phostriecin and key structural analogues.
Burke, Christopher P⋅Swingle, Mark R⋅Honkanen, Richard E and Boger, Dale L
The Journal of organic chemistry, vol. 75, (no. 22), pp. 7505-13, 2010/Nov/19. | Journal Article
2009
Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors.
Swingle, Mark R⋅Amable, Lauren⋅Lawhorn, Brian G⋅Buck, Suzanne B⋅Burke, Christopher P⋅Ratti, Pukar⋅Fischer, Kimberly L⋅Boger, Dale L and Honkanen, Richard E
The Journal of pharmacology and experimental therapeutics, vol. 331, (no. 1), pp. 45-53, 2009/Oct. | Journal Article
2008
Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer.
Golden, Teresa⋅Golden, T.⋅Aragon, Ileana V⋅Aragon, I.V.⋅Rutland, Beth⋅Rutland, B.⋅Tucker, J A⋅Tucker, J.A.⋅Shevde, L.A.⋅Shevde, Lalita A⋅Samant, R.S.⋅Samant, Rajeev S⋅Zhou, G.⋅Zhou, Guofei⋅Amable, Lauren⋅Amable, L.⋅Skarra, Danalea⋅Skarra, D.⋅Honkanen, R.E. and Honkanen, Richard E
Biochimica et biophysica acta, vol. 1782, (no. 4), pp. 259-70, 2008/Apr. | Journal Article
 
The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer
Golden, Teresa⋅Swingle, Mark and Honkanen, Richard E
Cancer and Metastasis Reviews, vol. 27, (no. 2), pp. 169-78, Jun 2008. | Journal Article
2006
Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2A alpha
Bonness, Kathy⋅Aragon, Ileana V⋅Rutland, Beth⋅Ofori-Acquah, Solomon⋅Dean, Nicholas M and Honkanen, Richard E
Molecular Cancer Therapeutics, vol. 5, (no. 11), pp. 2727-2736, 2006. | Journal Article
 
Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2Aalpha.
Bonness, Kathy⋅Aragon, Ileana V⋅Rutland, Beth⋅Ofori-Acquah, Solomon⋅Dean, Nicholas M and Honkanen, Richard E
Molecular cancer therapeutics, vol. 5, (no. 11), pp. 2727-36, 2006/Nov. | Journal Article
 
Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition.
Lawhorn, Brian G⋅Boga, Sobhana B⋅Wolkenberg, Scott E⋅Colby, David A⋅Gauss, Carla-Maria⋅Swingle, Mark R⋅Amable, Lauren⋅Honkanen, Richard E and Boger, Dale L
Journal of the American Chemical Society, vol. 128, (no. 51), pp. 16720-32, 2006/Dec/27. | Journal Article
2005
Glutamate inhibits protein phosphatases and promotes insulin exocytosis in pancreatic beta-cells.
Lehtihet, Mikael⋅Webb, Dominic-Luc⋅Honkanen, Richard E and Sjöholm, Ake
Biochemical and biophysical research communications, vol. 328, (no. 2), pp. 601-607, March 11, 2005. | Journal Article
2004
Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice
Golden, T.⋅Aragon, I. V⋅Zhou, G.⋅Cooper, S. R⋅Dean, NM and Honkanen, Richard E
Cancer Letters, vol. 215, (no. 1), pp. 95-100, 2004. | Journal Article
 
Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade.
Zhou, Guofei⋅Golden, Teresa⋅Aragon, Ileana V and Honkanen, Richard E
The Journal of biological chemistry, vol. 279, (no. 45), pp. 46595-605, 2004/Nov/5. | Journal Article
2003
Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition.
Buck, Suzanne B⋅Hardouin, Christophe⋅Ichikawa, Satoshi⋅Soenen, Danielle R⋅Gauss, C-M⋅Hwang, Inkyu⋅Swingle, Mark R⋅Bonness, Kathy M⋅Honkanen, Richard E and Boger, Dale L
Journal of the American Chemical Society, vol. 125, (no. 51), pp. 15694-5, 2003/Dec/24. | Journal Article
 
Identification of a Functional Link for the p53 Tumor Suppressor Protein in Dexamethasone-induced Growth Suppression
Urban, G.⋅Golden, T.⋅Aragon, I. V⋅Cowsert, L.⋅Cooper, S. R⋅Dean, NM and Honkanen, Richard E
Journal of Biological Chemistry, vol. 278, (no. 11), pp. 9747-9753, 2003. | Journal Article
 
Regulating the expression of protein phosphatase type 5.
Golden, Teresa A and Honkanen, Richard E
Methods in enzymology, vol. 366, pp. 372-390, 2003. | Journal Article
2002
Regulators of Serine / Threonine Protein Phosphatases at the Dawn of a Clinical Era?
Honkanen, Richard E and Golden, T.
Current Medicinal Chemistry, vol. 9, (no. 22), pp. 2055-2075, Nov 2002. | Journal Article
 
Use of antisense oligonucleotides: advantages, controls, and cardiovascular tissue.
Golden, Teresa⋅Dean, Nicholas M and Honkanen, Richard E
Microcirculation (New York, N.Y. : 1994), vol. 9, (no. 1), pp. 51-64, 2002/Jan. | Journal Article
2001
Identification of an Estrogen-inducible Phosphatase (PP5) That Converts MCF-7 Human Breast Carcinoma Cells into an Estrogen-independent Phenotype when Expressed Constitutively
Urban, G.⋅Golden, T.⋅Aragon, I. V⋅Scammell, JG⋅Dean, NM and Honkanen, Richard E
Journal of Biological Chemistry, vol. 276, (no. 29), pp. 27638-27646, 2001. | Journal Article
 
Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling
Dean, David A⋅Urban, Gudrun⋅Aragon, Ileana V⋅Swingle, Mark⋅Miller, Beth⋅Rusconi, Sandro⋅Bueno, Manuel⋅Dean, Nicholas M and Honkanen, Richard E
BMC Cell Biology, vol. 2, pp. 6-6, 2001. | Journal Article
 
Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling.
Dean, David A⋅Urban, G⋅Aragon, I V⋅Swingle, M⋅Miller, B⋅Rusconi, S⋅Bueno, M⋅Dean, N M and Honkanen, Richard E
BMC cell biology [electronic resource]. , vol. 2, pp. 6, 2001. | Journal Article
2000
Photoreceptor serine/threonine protein phosphatase type 7: cloning, expression, and functional analysis.
Huang, X⋅Swingle, M R and Honkanen, Richard E
Methods in enzymology, vol. 315, pp. 579-93, 2000. | Journal Article
 
Serine/threonine protein phosphatase type 1gamma1 is required for the completion of cytokinesis in human A549 lung carcinoma cells.
Cheng, A⋅Dean, N M and Honkanen, Richard E
The Journal of biological chemistry, vol. 275, (no. 3), pp. 1846-54, 2000/Jan/21. | Journal Article
 
Serine/Threonine Protein Phosphatase Type 1 gamma 1 Is Required for the Completion of Cytokinesis in Human A549 Lung Carcinoma Cells
Cheng, A.⋅Dean, NM and Honkanen, Richard E
Journal of Biological Chemistry, vol. 275, (no. 3), pp. 1846-1854, 2000. | Journal Article
1999
A low voltage-activated Ca2+ current mediates cytokine-induced pancreatic beta-cell death.
Wang, L⋅Bhattacharjee, Arin⋅Zuo, Z⋅Hu, Frank⋅Honkanen, Richard E⋅Berggren, P O and Li, M
Endocrinology, vol. 140, (no. 3), pp. 1200-4, 1999/Mar. | Journal Article
 
A Low Voltage-Activated Ca2+ Current Mediates Cytokine-Induced Pancreatic β-Cell Death.
Wang, Lin⋅Wang, Lin⋅Bhattacharjee, Arin⋅Bhattacharjee, Arin⋅Zuo, Zhuang⋅Zuo, Zhuang⋅Hu, Fuquan⋅Hu, Fuquan⋅Honkanen, Richard E⋅Honkanen, Richard E⋅Berggren, Per-Olof⋅Berggren, Per-Olof⋅Li, Ming and Li, Ming
Endocrinology, vol. 140, (no. 3), pp. 1200-1204, March 1, 1999. | Journal Article