85 Publications (Page 1 of 4)
2024
A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation.
Nguyen, Bao V⋅Özden, Can⋅Dong, Kairong⋅Torres-Ocampo, Ana P⋅Dziedzic, Noelle⋅Flaherty, Daniel⋅Huang, Jian⋅Sankura, Saketh⋅Abromson, Nikki Lyn⋅Tomchick, Diana R⋅Chen, Jianhan⋅Garman, Scott C and Stratton, Margaret M
bioRxiv : the preprint server for biology, March 27, 2024. | Journal Article
 
Data Science for Integrated Dynamic Structural Biology-the 21st IUPAB Congress session summary commentary
Tama, Florence and Chen, Jianhan
Biophysical reviews, vol. 16, (no. 5), pp. 529-531, Oct 2024. | Journal Article
 
Small Molecule NS11021 Promotes BK Channel Activation by Increasing Inner Pore Hydration
Nordquist, Erik B⋅Jia, Zhiguang and Chen, Jianhan
Journal of chemical information and modeling, Sep 12, 2024. | Journal Article
 
Structural basis for hyperpolarization-dependent opening of human HCN1 channel
Burtscher, Verena⋅Mount, Jonathan⋅Huang, Jian⋅Cowgill, John⋅Chang, Yongchang⋅Bickel, Kathleen⋅Chen, Jianhan⋅Yuan, Peng and Chanda, Baron
Nature communications, vol. 15, (no. 1), pp. 5216, Jun 18, 2024. | Journal Article
 
Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms
Huang, Jian⋅Korsunsky, Aron⋅Yazdani, Mahdieh and Chen, Jianhan
Frontiers in Molecular Neuroscience, Jan 11, 2024. | Journal Article
2023
Hydrophobic gating in bundle-crossing ion channels: a case study of TRPV4
Huang, Jian and Chen, Jianhan
Communications Biology, vol. 6, (no. 1), pp. 1094, 2023. | Journal Article
 
Incorporating physics to overcome data scarcity in predictive modeling of protein function: a case study of BK channels.
Nordquist, Erik⋅Zhang, Guohui⋅Barethiya, Shrishti⋅Ji, Nathan⋅White, Kelli M⋅Han, Lu⋅Jia, Zhiguang⋅Shi, Jingyi⋅Cui, Jianmin and Chen, Jianhan
bioRxiv : the preprint server for biology, June 26, 2023. | Journal Article
 
Incorporating physics to overcome data scarcity in predictive modeling of protein function: A case study of BK channels.
Nordquist, Erik⋅Zhang, Guohui⋅Barethiya, Shrishti⋅Ji, Nathan⋅White, Kelli M⋅Han, Lu⋅Jia, Zhiguang⋅Shi, Jingyi⋅Cui, Jianmin and Chen, Jianhan
PLoS computational biology, vol. 19, (no. 9), pp. e1011460, September 2023. | Journal Article
 
Machine Learning Generation of Dynamic Protein Conformational Ensembles
Li-E, Zheng⋅Li-E, Zheng⋅Barethiya, Shrishti⋅Barethiya, Shrishti⋅Nordquist, Erik⋅Chen, Jianhan and Chen, Jianhan
Molecules, vol. 28, (no. 10), 2023. | Journal Article
 
Re-Balancing Replica Exchange with Solute Tempering for Sampling Dynamic Protein Conformations.
Zhang, Yumeng⋅Liu, Xiaorong and Chen, Jianhan
Journal of chemical theory and computation, February 15, 2023. | Journal Article
 
Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.
Huang, Jian⋅Korsunsky, Aron⋅Yazdani, Mahdieh and Chen, Jianhan
Frontiers in molecular neuroscience, vol. 16, pp. 1334370, 2023. | Journal Article
 
Toward Accurate Simulation of Coupling between Protein Secondary Structure and Phase Separation.
Zhang, Yumeng⋅Li, Shanlong⋅Gong, Xiping and Chen, Jianhan
Journal of the American Chemical Society, December 19, 2023. | Journal Article
2022
Computationally-Aided Modeling of Hsp70-Client Interactions: Past, Present, and Future.
Nordquist, Erik B⋅Clerico, Eugenia M⋅Chen, Jianhan and Gierasch, Lila M
The journal of physical chemistry. B, August 30, 2022. | Journal Article
 
Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D.
Zhao, Jing⋅Liu, Xinyue⋅Blayney, Alan⋅Zhang, Yumeng⋅Gandy, Lauren⋅Olivia Mirsky, Paige⋅Smith, Nathan⋅Zhang, Fuming⋅Linhardt, Robert J⋅Chen, Jianhan⋅Baines, Christopher⋅Loh, Stewart N and Wang, Chunyu
Journal of molecular biology, pp. 167552, March 24, 2022. | Journal Article
 
Toward Accurate Coarse-Grained Simulations of Disordered Proteins and Their Dynamic Interactions.
Zhang, Yumeng⋅Liu, Xiaorong and Chen, Jianhan
Journal of chemical information and modeling, vol. 62, (no. 18), pp. 4523-4536, September 26, 2022. | Journal Article
 
Using Metadynamics To Explore the Free Energy of Dewetting in Biologically Relevant Nanopores.
Nordquist, Erik B⋅Schultz, Samantha A and Chen, Jianhan
The journal of physical chemistry. B, August 23, 2022. | Journal Article
2021
Advanced Sampling Methods for Multiscale Simulation of Disordered Proteins and Dynamic Interactions
Gong, Xiping⋅Gong, Xiping⋅Zhang, Yumeng⋅Zhang, Yumeng⋅Chen, Jianhan and Chen, Jianhan
Biomolecules, vol. 11, (no. 10), 2021. | Journal Article
 
Cancer-Associated Mutations Perturb the Disordered Ensemble and Interactions of the Intrinsically Disordered p53 Transactivation Domain.
Schrag, Lynn G⋅Schrag, Lynn G⋅Liu, Xiaorong⋅Liu, Xiaorong⋅Thevarajan, Indhujah⋅Thevarajan, Indhujah⋅Prakash, Om⋅Prakash, Om⋅Zolkiewski, Michal⋅Zolkiewski, Michal⋅Chen, Jianhan and Chen, Jianhan
Journal of molecular biology, pp. 167048, May 10, 2021. | Journal Article
 
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
Zhao, Jing⋅Zhao, Jing⋅Zhao, Jing⋅Zhao, Jing⋅Blayney, Alan⋅Blayney, Alan⋅Blayney, Alan⋅Blayney, Alan⋅Liu, Xiaorong⋅Liu, Xiaorong⋅Liu, Xiaorong⋅Liu, Xiaorong⋅Gandy, Lauren⋅Gandy, Lauren⋅Gandy, Lauren⋅Gandy, Lauren⋅Jin, Weihua⋅Jin, Weihua⋅Jin, Weihua⋅Jin, Weihua⋅Lufeng, Yan⋅Lufeng, Yan⋅Lufeng, Yan⋅Lufeng, Yan⋅Canning, Ashley J⋅Canning, Ashley J⋅Canning, Ashley J⋅Canning, Ashley J⋅Connelly, Michael⋅Connelly, Michael⋅Connelly, Michael⋅Connelly, Michael⋅Yang, Chao⋅Yang, Chao⋅Yang, Chao⋅Yang, Chao⋅Cosgrove, Michael S⋅Cosgrove, Michael S⋅Cosgrove, Michael S⋅Cosgrove, Michael S⋅Solmaz, Sozanne R⋅Solmaz, Sozanne R⋅Solmaz, Sozanne R⋅Solmaz, Sozanne R⋅⋅⋅⋅⋅Ban, David⋅Ban, David⋅Ban, David⋅Ban, David⋅Chen, Jianhan⋅Chen, Jianhan⋅Chen, Jianhan⋅Chen, Jianhan⋅Loh, Stewart N⋅Loh, Stewart N⋅Loh, Stewart N⋅Loh, Stewart N⋅Wang, Chunyu⋅Wang, Chunyu⋅Wang, Chunyu and Wang, Chunyu
Nature Communications, vol. 12, (no. 1), 2021. | Journal Article
 
Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones.
Nordquist, Erik B⋅English, Charles A⋅Clerico, Eugenia M⋅Sherman, Woody⋅Gierasch, Lila M⋅Gierasch, Lila M and Chen, Jianhan
PLoS computational biology, vol. 17, (no. 11), pp. e1009567, November 2021. | Journal Article
 
Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels.
Jia, Zhiguang and Chen, Jianhan
Communications biology, vol. 4, (no. 1), pp. 259, February 26, 2021. | Journal Article
2020
Accelerating atomistic simulations of proteins using multiscale enhanced sampling with independent tempering.
Liu, Xiaorong⋅Gong, Xiping and Chen, Jianhan
Journal of computational chemistry, December 10, 2020. | Journal Article
 
Bioinspired bio-voltage memristors
⋅Liu, Xiaomeng⋅Ward, Joy E⋅Liu, Xiaorong⋅Yin, Bing⋅Ye, Zhuo⋅Joshua, Yang J⋅Chen, Jianhan⋅ and Yao, Jun
Nature Communications, vol. 11, (no. 1), 2020. | Journal Article
 
Bioinspired bio-voltage memristors.
Fu, Tianda⋅Liu, Xiaomeng⋅Gao, Hongyan⋅Ward, Joy E⋅Liu, Xiaorong⋅Yin, Bing⋅Wang, Zhongrui⋅Zhuo, Ye⋅Walker, David J F⋅Joshua Yang, J⋅Chen, Jianhan⋅Lovley, Derek R and Yao, Jun
Nature communications, vol. 11, (no. 1), pp. 1861, April 20, 2020. | Journal Article
 
Different Anomeric Sugar Bound States of Maltose Binding Protein Resolved by a Cytolysin A Nanopore Tweezer.
Li, Xin⋅Lee, Kuo Hao⋅Shorkey, Spencer⋅Chen, Jianhan and Chen, Min
ACS nano, vol. 14, (no. 2), pp. 1727-1737, February 25, 2020. | Journal Article