79 Publications (Page 1 of 4)
2024
Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanismsHuang, Jian⋅Korsunsky, Aron⋅Yazdani, Mahdieh and Chen, JianhanFrontiers in Molecular Neuroscience, Jan 11, 2024.
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2023
Hydrophobic gating in bundle-crossing ion channels: a case study of TRPV4Huang, Jian and Chen, JianhanCommunications Biology, vol. 6, (no. 1), pp. 1094, 2023.
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Incorporating physics to overcome data scarcity in predictive modeling of protein function: a case study of BK channels.Nordquist, Erik⋅Zhang, Guohui⋅Barethiya, Shrishti⋅Ji, Nathan⋅White, Kelli M⋅Han, Lu⋅Jia, Zhiguang⋅Shi, Jingyi⋅Cui, Jianmin and Chen, JianhanbioRxiv : the preprint server for biology, June 26, 2023.
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Incorporating physics to overcome data scarcity in predictive modeling of protein function: A case study of BK channels.Nordquist, Erik⋅Zhang, Guohui⋅Barethiya, Shrishti⋅Ji, Nathan⋅White, Kelli M⋅Han, Lu⋅Jia, Zhiguang⋅Shi, Jingyi⋅Cui, Jianmin and Chen, JianhanPLoS computational biology, vol. 19, (no. 9), pp. e1011460, September 2023.
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Machine Learning Generation of Dynamic Protein Conformational EnsemblesLi-E, Zheng⋅Li-E, Zheng⋅Barethiya, Shrishti⋅Barethiya, Shrishti⋅Nordquist, Erik⋅Chen, Jianhan and Chen, JianhanMolecules, vol. 28, (no. 10), 2023.
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Re-Balancing Replica Exchange with Solute Tempering for Sampling Dynamic Protein Conformations.Zhang, Yumeng⋅Liu, Xiaorong and Chen, JianhanJournal of chemical theory and computation, February 15, 2023.
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Toward Accurate Simulation of Coupling between Protein Secondary Structure and Phase Separation.Zhang, Yumeng⋅Li, Shanlong⋅Gong, Xiping and Chen, JianhanJournal of the American Chemical Society, December 19, 2023.
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2022
Computationally-Aided Modeling of Hsp70-Client Interactions: Past, Present, and Future.Nordquist, Erik B⋅Clerico, Eugenia M⋅Chen, Jianhan and Gierasch, Lila MThe journal of physical chemistry. B, August 30, 2022.
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Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D.Zhao, Jing⋅Liu, Xinyue⋅Blayney, Alan⋅Zhang, Yumeng⋅Gandy, Lauren⋅Olivia Mirsky, Paige⋅Smith, Nathan⋅Zhang, Fuming⋅Linhardt, Robert J⋅Chen, Jianhan⋅Baines, Christopher⋅Loh, Stewart N and Wang, ChunyuJournal of molecular biology, pp. 167552, March 24, 2022.
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Toward Accurate Coarse-Grained Simulations of Disordered Proteins and Their Dynamic Interactions.Zhang, Yumeng⋅Liu, Xiaorong and Chen, JianhanJournal of chemical information and modeling, vol. 62, (no. 18), pp. 4523-4536, September 26, 2022.
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Using Metadynamics To Explore the Free Energy of Dewetting in Biologically Relevant Nanopores.Nordquist, Erik B⋅Schultz, Samantha A and Chen, JianhanThe journal of physical chemistry. B, August 23, 2022.
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2021
Advanced Sampling Methods for Multiscale Simulation of Disordered Proteins and Dynamic InteractionsGong, Xiping⋅Gong, Xiping⋅Zhang, Yumeng⋅Zhang, Yumeng⋅Chen, Jianhan and Chen, JianhanBiomolecules, vol. 11, (no. 10), 2021.
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Cancer-Associated Mutations Perturb the Disordered Ensemble and Interactions of the Intrinsically Disordered p53 Transactivation Domain.Schrag, Lynn G⋅Schrag, Lynn G⋅Liu, Xiaorong⋅Liu, Xiaorong⋅Thevarajan, Indhujah⋅Thevarajan, Indhujah⋅Prakash, Om⋅Prakash, Om⋅Zolkiewski, Michal⋅Zolkiewski, Michal⋅Chen, Jianhan and Chen, JianhanJournal of molecular biology, pp. 167048, May 10, 2021.
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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interactionZhao, Jing⋅Zhao, Jing⋅Zhao, Jing⋅Zhao, Jing⋅Blayney, Alan⋅Blayney, Alan⋅Blayney, Alan⋅Blayney, Alan⋅Liu, Xiaorong⋅Liu, Xiaorong⋅Liu, Xiaorong⋅Liu, Xiaorong⋅Gandy, Lauren⋅Gandy, Lauren⋅Gandy, Lauren⋅Gandy, Lauren⋅Jin, Weihua⋅Jin, Weihua⋅Jin, Weihua⋅Jin, Weihua⋅Lufeng, Yan⋅Lufeng, Yan⋅Lufeng, Yan⋅Lufeng, Yan⋅Canning, Ashley J⋅Canning, Ashley J⋅Canning, Ashley J⋅Canning, Ashley J⋅Connelly, Michael⋅Connelly, Michael⋅Connelly, Michael⋅Connelly, Michael⋅Yang, Chao⋅Yang, Chao⋅Yang, Chao⋅Yang, Chao⋅Cosgrove, Michael S⋅Cosgrove, Michael S⋅Cosgrove, Michael S⋅Cosgrove, Michael S⋅Solmaz, Sozanne R⋅Solmaz, Sozanne R⋅Solmaz, Sozanne R⋅Solmaz, Sozanne R⋅⋅⋅⋅⋅Ban, David⋅Ban, David⋅Ban, David⋅Ban, David⋅Chen, Jianhan⋅Chen, Jianhan⋅Chen, Jianhan⋅Chen, Jianhan⋅Loh, Stewart N⋅Loh, Stewart N⋅Loh, Stewart N⋅Loh, Stewart N⋅Wang, Chunyu⋅Wang, Chunyu⋅Wang, Chunyu and Wang, ChunyuNature Communications, vol. 12, (no. 1), 2021.
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Physics-based modeling provides predictive understanding of selectively promiscuous substrate binding by Hsp70 chaperones.Nordquist, Erik B⋅English, Charles A⋅Clerico, Eugenia M⋅Sherman, Woody⋅Gierasch, Lila M⋅Gierasch, Lila M and Chen, JianhanPLoS computational biology, vol. 17, (no. 11), pp. e1009567, November 2021.
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Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels.Jia, Zhiguang and Chen, JianhanCommunications biology, vol. 4, (no. 1), pp. 259, February 26, 2021.
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2020
Accelerating atomistic simulations of proteins using multiscale enhanced sampling with independent tempering.Liu, Xiaorong⋅Gong, Xiping and Chen, JianhanJournal of computational chemistry, December 10, 2020.
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Bioinspired bio-voltage memristors⋅Liu, Xiaomeng⋅Ward, Joy E⋅Liu, Xiaorong⋅Yin, Bing⋅Ye, Zhuo⋅Joshua, Yang J⋅Chen, Jianhan⋅ and Yao, JunNature Communications, vol. 11, (no. 1), 2020.
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Bioinspired bio-voltage memristors.Fu, Tianda⋅Liu, Xiaomeng⋅Gao, Hongyan⋅Ward, Joy E⋅Liu, Xiaorong⋅Yin, Bing⋅Wang, Zhongrui⋅Zhuo, Ye⋅Walker, David J F⋅Joshua Yang, J⋅Chen, Jianhan⋅Lovley, Derek R and Yao, JunNature communications, vol. 11, (no. 1), pp. 1861, April 20, 2020.
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Different Anomeric Sugar Bound States of Maltose Binding Protein Resolved by a Cytolysin A Nanopore Tweezer.Li, Xin⋅Lee, Kuo Hao⋅Shorkey, Spencer⋅Chen, Jianhan and Chen, MinACS nano, vol. 14, (no. 2), pp. 1727-1737, February 25, 2020.
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Modulation of p53 Transactivation Domain Conformations by Ligand Binding and Cancer-Associated Mutations.Liu, Xiaorong and Chen, JianhanPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, vol. 25, pp. 195-206, 2020.
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Power generation from ambient humidity using protein nanowiresLiu, Xiaomeng⋅Gao, Hongyan⋅Ward, Joy E⋅Liu, Xiaorong⋅Yin, Bing⋅Fu, Tianda⋅Chen, Jianhan⋅Lovley, Derek R and Yao, JunNature, vol. 578, (no. 7796), pp. 550-554,554A-554B, Feb 27, 2020.
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Targeting Intrinsically Disordered Proteins through Dynamic Interactions.Chen, Jianlin⋅Liu, Xiaorong and Chen, JianhanBiomolecules, vol. 10, (no. 5), May 11, 2020.
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2019
An inner activation gate controls TMEM16F phospholipid scrambling.Le, Trieu⋅Le, Trieu⋅Jia, Zhiguang⋅Jia, Zhiguang⋅Le, Son C⋅Le, Son C⋅Zhang, Yang⋅Zhang, Yang⋅Chen, Jianhan⋅Chen, Jianhan⋅Yang, Huanghe and Yang, HuangheNature communications, vol. 10, (no. 1), pp. 1846, April 23, 2019.
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Expression and Characterization of Manduca sexta Stress Responsive Peptide-1; an Inducer of Antimicrobial Peptide Synthesis.Schrag, Lynn G⋅Cao, Xiaolong⋅Dembele, Hawa⋅Liu, Xiaorong⋅Souhail, Qasim Al⋅Kanost, Michael R⋅Chen, Jianhan⋅Jiang, Haobo and Prakash, OmBiochemistry and molecular biology (New York, N.Y.), vol. 4, (no. 3), pp. 42-52, May 2019.
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