Several questions are currently of high interest to us:
- Functional interactions between channels and transporters
- Structure-function analysis of anion channels and transporters
Our laboratory studies the regulation, structure and function of proteins that both act as tumor suppressors and mediate the movement of solutes into and out of cells. We are particularly interested in the physical and functional interactions between members of the multidrug resistance/ATP binding cassette (MDR/ABC) and solute carrier (SLC) families of transport proteins.
We are especially interested in 1) defining the regulation of these transport proteins by MDR/ABC proteins within macromolecular signaling complexes, and 2) learning how their respective transport functions participate in basic processes that ultimately antagonize tumor formation.”
We are particularly interested in the physical and functional interactions between members of the multidrug resistance/ATP binding cassette (MDR/ABC) and solute carrier (SLC) families of transport proteins.
Dr. Fong’s present research focuses on how these proteins function in the physiological context of airways, pancreas, and thyroid, as well as glia and neurons within the central nervous system.
Research:
- Anatomy & Physiology – Studies regulation, structure and function of ion channels and transporters in macromolecular complexes
Expertise:
- Anatomy & Physiology - Studies how transporters organize and communicate within functional complexes in epithelia using cellular and molecular methods
Areas of expertise:
- Cell Signaling
- Epithelial physiology, membrane channels and transporters
- Endocrine physiology and function
- Cell migration and cell-to-cell contact
Keywords:
- Membrane transporters, channels & trafficking, thyroid dysfunction, cystic fibrosis
