16 Publications
2017
Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics
Garcia, Brandon L⋅Garcia, Brandon L⋅Andrew, Skaff D⋅Andrew, Skaff D⋅Hanning, Anders⋅Hanning, Anders⋅Walker, John K⋅Walker, John K⋅Wyckoff, Gerald J⋅Wyckoff, Gerald J⋅Geisbrecht, Brian V and Geisbrecht, Brian V
The Journal of Immunology, vol. 198, (no. 9), pp. 3705-3718, May 1, 2017. | Journal Article
2016
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex.
Garcia, Brandon L⋅Zhi, Hui⋅Wager, Beau⋅Höök, Magnus and Skare, Jon T
PLoS pathogens, vol. 12, (no. 1), pp. e1005404, January 2016. | Journal Article
 
Novel Evasion Mechanisms of the Classical Complement Pathway.
Garcia, Brandon L⋅Zwarthoff, Seline A⋅Rooijakkers, Suzan H M and Geisbrecht, Brian V
Journal of immunology (Baltimore, Md. : 1950), vol. 197, (no. 6), pp. 2051-2060, September 15, 2016. | Journal Article
2015
Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb.
Georgoutsou-Spyridonos, Maria⋅Ricklin, Daniel⋅Pratsinis, Haris⋅Perivolioti, Eustathia⋅Pirmettis, Ioannis⋅Garcia, Brandon L⋅Geisbrecht, Brian V⋅Foukas, Periklis G⋅Lambris, John D⋅Mastellos, Dimitrios C and Sfyroera, Georgia
Journal of immunology (Baltimore, Md. : 1950), vol. 195, (no. 8), pp. 3946-3958, October 15, 2015. | Journal Article
 
Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins.
Summers, Brady J⋅Garcia, Brandon L⋅Woehl, Jordan L⋅Ramyar, Kasra X⋅Yao, Xiaolan and Geisbrecht, Brian V
Molecular immunology, vol. 67, (no. 2 Pt B), pp. 193-205, October 2015. | Journal Article
 
Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects.
Takahashi, Daisuke⋅Garcia, Brandon L and Kanost, Michael R
Proceedings of the National Academy of Sciences of the United States of America, vol. 112, (no. 45), pp. 13856-13861, November 10, 2015. | Journal Article
2014
The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase.
Woehl, Jordan L⋅Stapels, Daphne A C⋅Garcia, Brandon L⋅Ramyar, Kasra X⋅Keightley, Andrew⋅Ruyken, Maartje⋅Syriga, Maria⋅Sfyroera, Georgia⋅Weber, Alexander B⋅Zolkiewski, Michal⋅Ricklin, Daniel⋅Lambris, John D⋅Rooijakkers, Suzan H M and Geisbrecht, Brian V
Journal of immunology (Baltimore, Md. : 1950), vol. 193, (no. 12), pp. 6161-6171, December 15, 2014. | Journal Article
2013
A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins.
Garcia, Brandon L⋅Summers, Brady J⋅Ramyar, Kasra X⋅Tzekou, Apostolia⋅Lin, Zhuoer⋅Ricklin, Daniel⋅Lambris, John D⋅Laity, John H and Geisbrecht, Brian
The Journal of biological chemistry, vol. 288, (no. 4), pp. 2870-81, 2013/Jan/25. | Journal Article
2012
Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins.
Garcia, Brandon L⋅Ramyar, Kasra X⋅Ricklin, Daniel⋅Lambris, John D and Geisbrecht, Brian
Advances in experimental medicine and biology, vol. 946, pp. 113-33, 2012. | Journal Article
 
Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family.
Garcia, Brandon L⋅Summers, Brady J⋅Lin, Zhuoer⋅Ramyar, Kasra X⋅Ricklin, Daniel⋅Kamath, Divya V⋅Fu, Zheng-Qing⋅Lambris, John D and Geisbrecht, Brian
The Journal of biological chemistry, vol. 287, (no. 1), pp. 628-40, 2012/Jan/2. | Journal Article
 
MAP1272c Encodes an NlpC/P60 Protein, an Antigen Detected in Cattle with Johne's Disease
Bannantine, John P⋅Lingle, Cari K⋅Stabel, Judith⋅Ramyar, Kasra X⋅Garcia, Brandon L⋅Raeber, Alex J⋅Schacher, Pascal⋅Kapur, Vivek and Geisbrecht, Brian
Clinical and Vaccine Immunology, vol. 19, (no. 7), pp. 1083-1092, 2012. | Journal Article
2010
Allosteric inhibition of complement function by a staphylococcal immune evasion protein.
Chen, Hui⋅Ricklin, Daniel⋅Hammel, Michal⋅Garcia, Brandon L⋅McWhorter, William J⋅Sfyroera, Georgia⋅Wu, You-Qiang⋅Tzekou, Apostolia⋅Li, Sheng⋅Geisbrecht, Brian⋅Woods, Virgil L and Lambris, John D
Proceedings of the National Academy of Sciences of the United States of America, vol. 107, (no. 41), pp. 17621-6, 2010/Oct/12. | Journal Article
 
Convertase Inhibitory Properties of Staphylococcal Extracellular Complement-binding Protein
Jongerius, Ilse⋅Garcia, Brandon L⋅Geisbrecht, Brian⋅Van Strijp, Jos A⋅van Strijp, Jos A G and Rooijakkers, Suzan H
Journal of Biological Chemistry, vol. 285, (no. 20), pp. 14973-14979, 2010. | Journal Article
 
Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b
Garcia, Brandon L⋅Ramyar, Kasra X⋅Tzekou, Apostolia⋅Ricklin, Daniel⋅McWhorter, William J⋅Lambris, John D and Geisbrecht, Brian
Journal of Molecular Biology, vol. 402, (no. 1), pp. 17-29, 2010. | Journal Article
2009
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family.
Ricklin, Daniel⋅Tzekou, Apostolia⋅Garcia, Brandon L⋅Hammel, Michal⋅McWhorter, William J⋅Sfyroera, Georgia⋅Wu, You-Qiang⋅Holers, Michael⋅Herbert, Andrew P⋅Barlow, Paul⋅Geisbrecht, Brian and Lambris, John D
Journal of immunology (Baltimore, Md. : 1950), vol. 183, (no. 4), pp. 2565-74, 2009/Aug/15. | Journal Article
 
Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN).
Garcia, Brandon L⋅Tzekou, Apostolia⋅Ramyar, Kasra X⋅McWhorter, William J⋅Ricklin, Daniel⋅Lambris, John D and Geisbrecht, Brian
Acta crystallographica. Section F, Structural biology and crystallization communications, vol. 65, (no. Pt 5), pp. 482-5, 2009/May/1. | Journal Article