The role of specific bacterial virulence factors in dental caries; improving the clinical efficacy of topical fluorides; fluoride distribution and clearance in the oral cavity; evaluation of the clinical efficacy of topical fluorides using in situ caries models; development and evaluation of new methods of early caries detection and caries lesion activity assessment; evaluation of etiology and prevention of dental erosion using in vitro and in situ models; evaluating salivary diagnostic biomarkers; use of biologics for the treatment of Sjogren's Disease and TMD.
