11 Publications
2011
Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase.
Chai, Sergio⋅Wang, Wen-Long⋅Ding, De-Rong and Ye, Qi Zhuang
European journal of medicinal chemistry, vol. 46, (no. 8), pp. 3537-40, 2011/Aug. | Journal Article
 
Synthesis and biological evaluation of salicylate-based compounds as a novel class of methionine aminopeptidase inhibitors
Wang, Wen-Long⋅Chai, Sergio and Ye, Qi Zhuang
Bioorganic and Medicinal Chemistry Letters, vol. 21, (no. 23), pp. 7151-7154, 2011. | Journal Article
 
Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes
Yuan, Hai⋅Chai, Sergio⋅Lam, Christopher K⋅Xu, HHoward and Ye, Qi Zhuang
Bioorganic and Medicinal Chemistry Letters, vol. 21, (no. 11), pp. 3395-3398, 2011. | Journal Article
2010
A cell-based assay that targets methionine aminopeptidase in a physiologically relevant environment
Chai, Sergio and Ye, Qi Zhuang
Bioorganic and Medicinal Chemistry Letters, vol. 20, (no. 7), pp. 2129-2132, 2010. | Journal Article
 
Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase.
Lu, Jing-Ping⋅Chai, Sergio and Ye, Qi Zhuang
Journal of medicinal chemistry, vol. 53, (no. 3), pp. 1329-37, 2010/Feb/11. | Journal Article
2009
Analysis of the stoichiometric metal activation of methionine aminopeptidase.
Chai, Sergio and Ye, Qi Zhuang
BMC biochemistry, vol. 10, pp. 32, 2009. | Journal Article
 
Determination of binding affinity of metal cofactor to the active site of methionine aminopeptidase based on quantitation of functional enzyme
Chai, Sergio⋅Lu, Jing-Ping and Ye, Qi Zhuang
Analytical Biochemistry, vol. 395, (no. 2), pp. 263-264, 2009. | Journal Article
 
Metal-mediated inhibition is a viable approach for inhibiting cellular methionine aminopeptidase
Chai, Sergio and Ye, Qi Zhuang
Bioorganic and Medicinal Chemistry Letters, vol. 19, (no. 24), pp. 6862-6864, 2009. | Journal Article
 
Synthesis and structure-function analysis of Fe(II)-form-selective antibacterial inhibitors of Escherichia coli methionine aminopeptidase
Wang, Wen-Long⋅Chai, Sergio and Ye, Qi Zhuang
Bioorganic and Medicinal Chemistry Letters, vol. 19, (no. 4), pp. 1080-1083, 2009. | Journal Article
2008
Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity.
Wang, Wen-Long⋅WL, Wang⋅Chai, Sergio⋅SC, Chai⋅Huang, Min⋅M, Huang⋅He, Hong-Zhen⋅HZ, He⋅Hurley, Thomas D⋅TD, Hurley⋅Ye, Qi Zhuang and QZ, Ye
Journal of medicinal chemistry, vol. 51, (no. 19), pp. 6110-20, 2008/Oct/9. | Journal Article
 
FE(II) Is the Native Cofactor for Escherichia coli Methionine Aminopeptidase.
Chai, Sergio⋅Wang, Wen-Long and Ye, Qi Zhuang
Journal of biological chemistry., vol. 283, (no. 40), pp. 26879-26885, 2008. | Journal Article