The focus of my laboratory is to investigate the structure and function of large multi-protein complexes in gene expression in eukaryotes.
The current projects include (i) reconstitution and structure determination of the entire Mediator complex, which is composed of 21 subunits (see Figure 1), (ii) structure-guided functional studies of the mechanisms of Mediator, (iii) reconstitution of multi-protein complexes involved in gene expressions, and (iv) engineering of protein complex expression and purification technologies.
