The focus of my laboratory is to investigate the structure and function of large multi-protein complexes in gene expression in eukaryotes.

The current projects include (i) reconstitution and structure determination of the entire Mediator complex, which is composed of 21 subunits (see Figure 1), (ii) structure-guided functional studies of the mechanisms of Mediator, (iii) reconstitution of multi-protein complexes involved in gene expressions, and (iv) engineering of protein complex expression and purification technologies.

Past Affiliations
Biochemistry, Biochemistry, Molecular Biology, Cellular Biochemistry, Molecular Biochemistry, Chemistry
PhD, University of Oklahoma, Biochemistry, 1997
MS, University of Tokyo, Chemistry, 1989
BS, Ibaraki University, Chemistry, 1987
biochemistry & molecular biology

Research Frontiers Trailblazer Award, IUPUI Office of the Vice Chancellor for Research, 2014