My research interests are in the areas of: a) cardiovascular biomechanics (e.g., coronary circulation and tissue mechanics) related to stenosis, hypertension, and heart failure, b) mechanobiology (e.g., oxidative stress and redox signaling in endothelium and integrin-mediated mechanotransduction in smooth muscle cells) for arterial stiffness and aging, and c) innovative diagnosis and bioinstrumentation. Most of the present work makes use of physical principles, with the help of bio-imaging techniques, physiological measurements in large animal models or patients, and theoretical analysis, to explain and predict coronary heart diseases in quantitative and statistical terms.
