Special interest:
- to investigate the novel approach that PAF-R agonists generated via oxidative stressors (environmental exposure or therapeutic treatments) suppress the host immunity and thus could compromise the effectiveness of immunotherapy against melanoma
- to test novel approach that suppressing PAF-R activation could block these oxidized lipids induced systemic immunosuppression and thus could increase the efficacy of melanoma immunotherapy and
- to investigate potential suppressive immune subtypes involved in this process.
My long term research career goals are to understand the mechanisms by which pro-oxidative stressors generated platelet-activating factor (PAF) agonists mediate systemic immunosuppressive effects and modulate melanoma tumor growth. I am also interested in (1) determining the role and effects of the immunomodulatory events triggered by PAF-agonists in the therapeutic interventions of melanoma and (2) to investigate potentially successful approach that could enhance the efficacy of melanoma therapies via augmenting host anti-tumor immune responses.
