128 Publications (Page 3 of 6)
2010
Updated Functional Classification of ?-Lactamases
Bush, Karen and Jacoby, George A
Antimicrobial Agents & Chemotherapy, vol. 54, (no. 3), pp. 969-976, 2010. | Journal Article
2009
Comment on: Redefining extended-spectrum β-lactamases: balancing science and clinical need
Bush, Karen⋅Bush, Karen⋅Jacoby, George A⋅Jacoby, George A⋅Amicosante, Gianfranco⋅Amicosante, Gianfranco⋅Bonomo, Robert A⋅Bonomo, Robert A⋅Bradford, Patricia⋅Bradford, Patricia⋅Cornaglia, Giuseppe⋅Cornaglia, Giuseppe⋅Garau, Javier⋅Garau, Javier⋅Giamarellou, Helen⋅Giamarellou, Helen⋅Jarlier, Vincent⋅Jarlier, Vincent⋅Martinez-Martinez, Luis⋅Martinez-Martinez, Luis⋅Miriagou, Vivi⋅Miriagou, Vivi⋅Palzkill, Timothy G⋅Palzkill, Timothy⋅Pascual, Alvaro⋅Pascual, Alvaro⋅Rodriguez-Baño, Jesus⋅Rodriguez-Baño, Jesus⋅Rossolini, Gian M⋅Rossolini, Gian Maria⋅Sougakoff, Wladimir⋅Sougakoff, Wladimir⋅Vatopoulos, Alkiviadis and Vatopoulos, Alkiviadis
Journal of Antimicrobial Chemotherapy, vol. 64, (no. 1), pp. 213, 20090700. | Journal Article
 
Effect of MexXY overexpression on ceftobiprole susceptibility in Pseudomonas aeruginosa.
Baum, Ellen Z⋅Crespo-Carbone, Steven M⋅Morrow, Brian J⋅Davies, Todd A⋅Foleno, Barbara D⋅He, Wenping⋅Queenan, Anne M and Bush, Karen
Antimicrobial agents and chemotherapy, vol. 53, (no. 7), pp. 2785-90, 2009/Jul. | Journal Article
 
Molecular characterisation of meticillin-resistant Staphylococcus aureus isolates from two ceftobiprole Phase 3 complicated skin and skin-structure infection clinical trials
Davies, Todd⋅Shang, Wenchi⋅Amsler, Karen⋅Bajaksouzian, Saralee⋅Jacobs, Michael and Bush, Karen
International Journal of Antimicrobial Agents, vol. 34, (no. 2), pp. 168, 2009. | Journal Article
 
MurF inhibitors with antibacterial activity: effect on muropeptide levels.
Baum, Ellen Z⋅Crespo-Carbone, Steven M⋅Foleno, Barbara D⋅Simon, Lee D⋅Guillemont, Jerome⋅Macielag, Mark and Bush, Karen
Antimicrobial agents and chemotherapy, vol. 53, (no. 8), pp. 3240-7, 2009/Aug. | Journal Article
 
Synthesis and antibacterial activity of 7-(1,2,3,4-tetrahydropyrrolo[1,2- a]pyrazin-7-yl) quinolones
Zhu, Bin⋅Marinelli, Brett A⋅Goldschmidt, Raul⋅Foleno, Barbara D⋅Hilliard, Jamese J⋅Bush, Karen and Macielag, Mark J
Bioorganic & Medicinal Chemistry Letters, vol. 19, (no. 17), pp. 4936, 2009. | Journal Article
2008
Activity of doripenem and comparator β-lactams against US clinical isolates of Streptococcus pneumoniae with defined mutations in the penicillin-binding domains of pbp1a, pbp2b and pbp2x
Davies, Todd A⋅Shang, Wenchi⋅Bush, Karen and Flamm, Robert K
Journal of Antimicrobial Chemotherapy, vol. 61, (no. 3), pp. 753, 20080300. | Journal Article
 
Affinity of Doripenem and Comparators to Penicillin-Binding Proteins in Escherichia coli and Pseudomonas aeruginosa
Davies, Todd⋅Shang, Wenchi⋅Bush, Karen and Flamm, Robert
Antimicrobial Agents and Chemotherapy, vol. 52, (no. 4), pp. 1512, 20080401. | Journal Article
 
A Randomized, Double-Blind Trial Comparing Ceftobiprole Medocaril with Vancomycin Plus Ceftazidime for the Treatment of Patients with Complicated Skin and Skin-Structure Infections
Noel, Gary⋅Bush, Karen⋅Bagchi, Partha⋅Ianus, Juliana and Strauss, Richard
Clinical Infectious Diseases, vol. 46, (no. 5), pp. 655, 20080301. | Journal Article
 
Characterization and Dynamics of Middle Ear Fluid and Nasopharyngeal Isolates of Streptococcus pneumoniae from 12 Children Treated with Levofloxacin
Davies, Todd⋅Leibovitz, Eugene⋅Noel, Gary⋅McNeeley, David⋅Bush, Karen and Dagan, Ron
Antimicrobial Agents and Chemotherapy, vol. 52, (no. 1), pp. 381, 20080101. | Journal Article
 
Effects of the 7-Valent Pneumococcal Conjugate Vaccine on U.S. Levofloxacin-ResistantStreptococcus pneumoniae
Davies, Todd A⋅Yee, Y. Cheung⋅Bush, Karen⋅Sahm, Dan⋅Evangelista, Alan and Goldschmidt, Raul
Microbial Drug Resistance, vol. 14, (no. 3), pp. 196, 2008-09-00. | Journal Article
 
In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
Amsler, Karen M⋅Davies, Todd A⋅Shang, Wenchi⋅Jacobs, Michael R and Bush, Karen
Antimicrobial agents and chemotherapy, vol. 52, (no. 9), pp. 3418-23, 2008/Sep. | Journal Article
2007
A MurF Inhibitor That Disrupts Cell Wall Biosynthesis in Escherichia coli
Baum, Ellen⋅Crespo-Carbone, Steven⋅Klinger, Alexandra⋅Foleno, Barbara⋅Turchi, Ignatius⋅Macielag, Mark and Bush, Karen
Antimicrobial Agents and Chemotherapy, vol. 51, (no. 12), pp. 4426, 20071201. | Journal Article
 
Anti-MRSA -lactams in development, with a focus on ceftobiprole: the first anti-MRSA -lactam to demonstrate clinical efficacy
Bush, Karen⋅Heep, Markus⋅Macielag, Mark J and Noel, Gary J
Expert Opinion on Investigational Drugs, vol. 16, (no. 4), pp. 429, April 2007. | Journal Article
 
Binding of Ceftobiprole and Comparators to the Penicillin-Binding Proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae
Davies, Todd A⋅Page, Malcolm G⋅Shang, Wenchi⋅Andrew, Ted⋅Kania, Malgosia and Bush, Karen
Antimicrobial Agents & Chemotherapy, vol. 51, (no. 7), pp. 2621-2624, 2007. | Journal Article
 
Carbapenemases: the versatile beta-lactamases.
Queenan, Anne M and Bush, Karen
Clinical microbiology reviews, vol. 20, (no. 3), pp. 440-58, table of contents, 2007/Jul. | Journal Article
 
Interactions of Ceftobiprole with β-Lactamases from Molecular Classes A to D
Queenan, Anne⋅Shang, Wenchi⋅Kania, Malgosia⋅Page, Malcolm and Bush, Karen
Antimicrobial Agents and Chemotherapy, vol. 51, (no. 9), pp. 3095, 20070901. | Journal Article
 
In Vitro Antibacterial Activity of the Pyrrolopyrazolyl-Substituted Oxazolidinone RWJ-416457
Foleno, Barbara⋅Abbanat, Darren⋅Goldschmidt, Raul⋅Flamm, Robert⋅Paget, Steve⋅Webb, Glenda⋅Wira, Ellyn⋅Macielag, Mark and Bush, Karen
Antimicrobial Agents and Chemotherapy, vol. 51, (no. 1), pp. 365, 20070101. | Journal Article
 
Preparation of Erythromycin Analogues Having Functional Groups at C-15
Ashley, Gary W⋅Burlingame, Mark⋅Desai, Ruchir⋅Fu, Hong⋅Leaf, Tim⋅Licari, Peter J⋅Tran, Chau⋅Abbanat, Darren⋅Bush, Karen and Macielag, Mark
ChemInform, vol. 38, (no. 3), 2007-01-16. | Journal Article
 
Synthesis and antibacterial activity of 3-keto-6- O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives
Zhu, Bin⋅Marinelli, Brett A⋅Abbanat, Darren⋅Foleno, Barbara D⋅Bush, Karen and Macielag, Mark J
Bioorganic & Medicinal Chemistry Letters, vol. 17, (no. 14), pp. 3904, 2007. | Journal Article
2006
Activities of Ceftobiprole and Other β-Lactams against Streptococcus pneumoniae Clinical Isolates from the United States with Defined Substitutions in Penicillin-Binding Proteins PBP 1a, PBP 2b, and PBP 2x
Davies, Todd⋅Shang, Wenchi and Bush, Karen
Antimicrobial Agents and Chemotherapy, vol. 50, (no. 7), pp. 2532, 20060701. | Journal Article
 
Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements
Paget, Steven D⋅Boggs, Christine M⋅Foleno, Barbara D⋅Goldschmidt, Raul M⋅Hlasta, Dennis J⋅Weidner-Wells, Michele A⋅Werblood, Harvey M⋅Bush, Karen and Macielag, Mark J
Bioorganic & Medicinal Chemistry Letters, vol. 16, (no. 17), pp. 4542, 2006. | Journal Article
 
Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
Robicsek, Ari⋅Strahilevitz, Jacob⋅Jacoby, George A⋅Macielag, Mark⋅Abbanat, Darren⋅Park, Chi H⋅Bush, Karen and Hooper, David C
Nature Medicine, vol. 12, (no. 1), pp. 83-88, 2006. | Journal Article
 
Infrequent occurrence of single mutations in topoisomerase IV and DNA gyrase genes among US levofloxacin-susceptible clinical isolates of Streptococcus pneumoniae from nine institutions (1999–2003)
Davies, Todd A⋅Yee, Y Cheung⋅Goldschmidt, Raul⋅Bush, Karen⋅Sahm, Daniel F and Evangelista, Alan
The Journal of antimicrobial chemotherapy, vol. 57, (no. 3), pp. 442, 2006-Mar. | Journal Article
 
Preparation of Erythromycin Analogs Having Functional Groups at C-15
Ashley, Gary W⋅Burlingame, Mark⋅Desai, Ruchir⋅Fu, Hong⋅Leaf, Tim⋅Licari, Peter J⋅Tran, Chau⋅Abbanat, Darren⋅Bush, Karen and Macielag, Mark
The Journal of Antibiotics, vol. 59, (no. 7), pp. 401, 2006-07-00. | Journal Article