33 Publications (Page 1 of 2)
2021
Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors.
Bellail, Anita C⋅Bellail, Anita C⋅Bellail, Anita C⋅Bellail, Anita C⋅Jin, Hong Ri⋅Jin, Hong Ri⋅Jin, Hong Ri⋅Jin, Hong Ri⋅Lo, Ho-Yin⋅Lo, Ho-Yin⋅Lo, Ho-Yin⋅Lo, Ho-Yin⋅Jung, Sung Han⋅Jung, Sung Han⋅Jung, Sung Han⋅Jung, Sung Han⋅Hamdouchi, Chafiq⋅Hamdouchi, Chafiq⋅Hamdouchi, Chafiq⋅Hamdouchi, Chafiq⋅Kim, Daeho⋅Kim, Daeho⋅Kim, Daeho⋅Kim, Daeho⋅Higgins, Ryan K⋅Higgins, Ryan K⋅Higgins, Ryan K⋅Higgins, Ryan K⋅Blanck, Maximilian⋅Blanck, Maximilian⋅Blanck, Maximilian⋅Blanck, Maximilian⋅le Sage, Carlos⋅le Sage, Carlos⋅le Sage, Carlos⋅le Sage, Carlos⋅Cross, Benedict C S⋅Cross, Benedict C S⋅Cross, Benedict C S⋅Cross, Benedict C S⋅Li, Jing⋅Li, Jing⋅Li, Jing⋅Li, Jing⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Wijeratne, Aruna B⋅Wijeratne, Aruna B⋅Wijeratne, Aruna B⋅Wijeratne, Aruna B⋅Jiang, Wen⋅Jiang, Wen⋅Jiang, Wen⋅Jiang, Wen⋅Ghosh, Manali⋅Ghosh, Manali⋅Ghosh, Manali⋅Ghosh, Manali⋅Zhao, Yin Quan⋅Zhao, Yin Quan⋅Zhao, Yin Quan⋅Zhao, Yin Quan⋅Hauck, Paula M⋅Hauck, Paula M⋅Hauck, Paula M⋅Hauck, Paula M⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Hao, Chunhai⋅Hao, Chunhai⋅Hao, Chunhai and Hao, Chunhai
Science translational medicine, vol. 13, (no. 615), pp. eabh1486, October 13, 2021. | Journal Article
2018
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus
Hamdouchi, Chafiq⋅Maiti, Pranab⋅Warshawsky, Alan M⋅DeBaillie, Amy C⋅Otto, Keith A⋅Wilbur, Kelly L⋅Kahl, Steven D⋅Patel Lewis, Anjana⋅Cardona, Guemalli R⋅Zink, Richard W⋅Chen, Keyue⋅CR, Siddaramaiah⋅Lineswala, Jayana P⋅Neathery, Grace L⋅Bouaichi, Cecilia⋅Diseroad, Benjamin A⋅Campbell, Alison N⋅Sweetana, Stephanie A⋅Adams, Lisa A⋅Cabrera, Over⋅Ma, Xiaosu⋅Yumibe, Nathan P⋅Montrose-Rafizadeh, Chahrzad⋅Chen, Yanyun and Miller, Anne Reifel
Journal of Medicinal Chemistry, vol. 61, (no. 3), pp. 945, 20180208. | Journal Article
 
Structural basis for GPR40 allosteric agonism and incretin stimulation
Ho, Joseph D⋅Chau, Betty⋅Rodgers, Logan⋅Lu, Frances⋅Wilbur, Kelly L⋅Otto, Keith A⋅Chen, Yanyun⋅Song, Min⋅Riley, Jonathan P⋅Yang, Hsiu-Chiung⋅Reynolds, Nichole A⋅Kahl, Steven D⋅Lewis, Anjana Patel⋅Groshong, Christopher⋅Madsen, Russell E⋅Conners, Kris⋅Lineswala, Jayana P⋅Gheyi, Tarun⋅Saflor, Melbert-Brian Decipulo⋅Lee, Matthew R⋅Benach, Jordi⋅Baker, Kenton A⋅Montrose-Rafizadeh, Chahrzad⋅Genin, Michael J⋅Miller, Anne R and Hamdouchi, Chafiq
Nature communications, vol. 9, (no. 1), pp. 11, 2018-04-25. | Journal Article
2016
A selective GPR40 (FFAR1) agonist LY2881835 provides immediate and durable glucose control in rodent models of type 2 diabetes
Chen, Yanyun⋅Song, Min⋅Riley, Jonathan P⋅Hu, Charlie C⋅Peng, Xianbu⋅Scheuner, Donalyn⋅Bokvist, Krister⋅Maiti, Pranab⋅Kahl, Steven D⋅Montrose‐Rafizadeh, Chahrzad⋅Hamdouchi, Chafiq and Miller, Anne Reifel
Pharmacology Research & Perspectives, vol. 4, (no. 6), pp. n/a, December 2016. | Journal Article
 
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470)
Hamdouchi, Chafiq⋅Kahl, Steven D⋅Patel Lewis, Anjana⋅Cardona, Guemalli R⋅Zink, Richard W⋅Chen, Keyue⋅Eessalu, Thomas E⋅Ficorilli, James V⋅Marcelo, Marialuisa C⋅Otto, Keith A⋅Wilbur, Kelly L⋅Lineswala, Jayana P⋅Piper, Jared L⋅Coffey, D. Scott⋅Sweetana, Stephanie A⋅Haas, Joseph V⋅Brooks, Dawn A⋅Pratt, Edward J⋅Belin, Ruth M⋅Deeg, Mark A⋅Ma, Xiaosu⋅Cannady, Ellen A⋅Johnson, Jason T⋅Yumibe, Nathan P⋅Chen, Qi⋅Maiti, Pranab⋅Montrose-Rafizadeh, Chahrzad⋅Chen, Yanyun and Reifel Miller, Anne
Journal of Medicinal Chemistry, vol. 59, (no. 24), pp. 10916, 20161222. | Journal Article
2009
Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond
Ciccocioppo, Roberto⋅Ciccocioppo, Roberto⋅Gehlert, Donald R.⋅Gehlert, Donald R⋅Ryabinin, Andrey⋅Ryabinin, Andrey⋅Kaur, Simranjit⋅Kaur, Simranjit⋅Cippitelli, Andrea⋅Cippitelli, Andrea⋅Thorsell, Annika⋅Thorsell, Annika⋅Lê, Anh D⋅Lê, Anh D.⋅Hipskind, Philip A⋅Hipskind, Philip A.⋅Hamdouchi, Chafiq⋅Hamdouchi, Chafiq⋅Lu, Jianliang⋅Lu, Jianliang⋅Hembre, Erik J⋅Hembre, Erik J.⋅Cramer, Jeffrey⋅Cramer, Jeffrey⋅Song, Min⋅Song, Min⋅Mc Kinzie, David L⋅McKinzie, David⋅Morin, Michelle⋅Morin, Michelle⋅Economidou, Daina⋅Economidou, Daina⋅Stopponi, Serena⋅Stopponi, Serena⋅Cannella, Nazzareno⋅Cannella, Nazzareno⋅Braconi, Simone⋅Braconi, Simone⋅Kallupi, Marsida⋅Kallupi, Marsida⋅de Guglielmo, Giordano⋅de Guglielmo, Giordano⋅Massi, Maurizio⋅Massi, Maurizio⋅George, David T⋅George, David T.⋅Gilman, Jody⋅Gilman, Jody⋅Hersh, Jacqueline R⋅Hersh, Jacqueline⋅Tauscher, Johannes T.⋅Tauscher, Johannes T⋅Hunt, Stephen P⋅Hunt, Stephen P.⋅Hommer, Daniel⋅Hommer, Daniel⋅Heilig, Markus and Heilig, Markus
Alcohol, vol. 43, (no. 7), pp. 491-8, 2009. | Journal Article
2007
3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with Efficacy in Animal Models of Alcoholism
Gehlert, Donald⋅Gehlert, Donald⋅Cippitelli, Andrea⋅Cippitelli, Andrea⋅Thorsell, Annika⋅Thorsell, Annika⋅Le, Anh⋅Le, Anh⋅Hipskind, Philip⋅Hipskind, Philip⋅Hamdouchi, Chafiq⋅Hamdouchi, Chafiq⋅Lu, Jianliang⋅Lu, Jianliang⋅Hembre, Erik⋅Hembre, Erik⋅Cramer, Jeffrey⋅Cramer, Jeffrey⋅Song, Min⋅Song, Min⋅McKinzie, David⋅McKinzie, David⋅Morin, Michelle⋅Morin, Michelle⋅Ciccocioppo, Roberto⋅Ciccocioppo, Roberto⋅Heilig, Markus and Heilig, Markus
Journal of Neuroscience, vol. 27, (no. 10), pp. 2726, 20070307. | Journal Article
 
Delayed Functional Expression of Neuronal Chemokine Receptors Following Focal Nerve Demyelination in the Rat: A Mechanism for the Development of Chronic Sensitization of Peripheral Nociceptors
Bhangoo, Sonia⋅Bhangoo, Sonia⋅Ren, Dongjun⋅Ren, Dongjun⋅Miller, Richard J⋅Miller, Richard J⋅Henry, Kenneth J⋅Henry, Kenneth J⋅Lineswala, Jayana⋅Lineswala, Jayana⋅Hamdouchi, Chafiq⋅Hamdouchi, Chafiq⋅Li, Baolin⋅Li, Baolin⋅Monahan, Patrick E⋅Monahan, Patrick E⋅Chan, David M⋅Chan, David M⋅Ripsch, Matthew S⋅Ripsch, Matthew S⋅White, Fletcher A and White, Fletcher A
Molecular Pain, vol. 3, (no. 1), pp. 38, 20071212. | Journal Article
2006
Stereodynamics of Ar–CO rotation and conformational preferences of 2-amino-3-(2,4-difluorobenzoyl)-imidazo[1,2- a]pyridine
Jaramillo, Carlos⋅de Diego, José Eugenio⋅Rivera-Sagredo, Alfonso⋅Hamdouchi, Chafiq and Espinosa, Juan F
Tetrahedron, vol. 62, (no. 52), pp. 12419, 2006. | Journal Article
2005
Cloning and functional characterization of the rabbit C-C chemokine receptor 2
Lu, Deshun⋅Yuan, Xiu-juan⋅Evans, Jr, Robert J⋅Pappas, Amy T⋅Wang, He⋅Su, Eric W⋅Hamdouchi, Chafiq and Venkataraman, Chandrasekar
BMC immunology, vol. 6, (no. 1), pp. 15, 2005-Jul-07. | Journal Article
 
Structure-based design of a new class of highly selective aminoimidazo[1,2- a]pyridine-based inhibitors of cyclin dependent kinases
Hamdouchi, C.⋅Hamdouchi, Chafiq⋅Zhong, Boyu⋅Zhong, B.⋅Mendoza, Jose⋅Mendoza, J.⋅Collins, Elizabeth⋅Collins, E.⋅Jaramillo, Carlos⋅Jaramillo, C.⋅De Diego, Jose Eugenio⋅De Diego, J.E.⋅Robertson, Daniel⋅Robertson, D.⋅Spencer, C.D.⋅Spencer, Charles D⋅Anderson, Bryan D⋅Anderson, B.D.⋅Watkins, S.A.⋅Watkins, Scott A⋅Zhang, Faming⋅Zhang, F.⋅Brooks, H.B. and Brooks, Harold B
Bioorganic & Medicinal Chemistry Letters, vol. 15, (no. 7), pp. 1947, 2005. | Journal Article
 
Structure‐Based Design of a New Class of Highly Selective Aminoimidazo[1,2‐a]pyridine‐Based Inhibitors of Cyclin Dependent Kinases
Hamdouchi, Chafiq and et al, et al
ChemInform, vol. 36, (no. 30), pp. no, July 26, 2005. | Journal Article
2004
Aminoimidazo[1,2- a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation
Jaramillo, Carlos⋅Jaramillo, Carlos⋅de Diego, J. Eugenio⋅de Diego, J. Eugenio⋅Hamdouchi, Chafiq⋅Hamdouchi, Chafiq⋅Collins, Elizabeth⋅Collins, Elizabeth⋅Keyser, Heather⋅Keyser, Heather⋅Sánchez-Martı́nez, Concha⋅Sánchez-Martı́nez, Concha⋅del Prado, Miriam⋅del Prado, Miriam⋅Norman, Bryan⋅Norman, Bryan⋅Brooks, Harold B⋅Brooks, Harold B⋅Watkins, Scott A⋅Watkins, Scott A⋅Spencer, Charles D⋅Spencer, Charles D⋅Dempsey, Jack Alan⋅Dempsey, Jack Alan⋅Anderson, Bryan D⋅Anderson, Bryan D⋅Campbell, Robert M⋅Campbell, Robert M⋅Leggett, Tellie⋅Leggett, Tellie⋅Patel, Bharvin⋅Patel, Bharvin⋅Schultz, Richard M⋅Schultz, Richard M⋅Espinosa, Juan⋅Espinosa, Juan⋅Vieth, Michal⋅Vieth, Michal⋅Zhang, Faming⋅Zhang, Faming⋅Timm, David E and Timm, David E
Bioorganic & Medicinal Chemistry Letters, vol. 14, (no. 24), pp. 6099, 2004. | Journal Article
 
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines
Hamdouchi, Chafiq⋅Keyser, Heather⋅Collins, Elizabeth⋅Jaramillo, Carlos⋅Diego, Jose⋅Spencer, Charles⋅Dempsey, Jack⋅Anderson, Bryan⋅Leggett, Tillie⋅Stamm, Nancy⋅Schultz, Richard⋅Watkins, Scott⋅Cocke, Kim⋅Lemke, Stephanie⋅Burke, Teresa⋅Beckmann, Richard⋅Dixon, Jeffrey⋅Gurganus, Thomas⋅Rankl, Nancy⋅Houck, Keith⋅Zhang, Faming⋅Vieth, Michal⋅Espinosa, Juan⋅Timm, David⋅Campbell, Robert⋅Patel, Bharvin and Brooks, Harold
Molecular Cancer Therapeutics, vol. 3, (no. 1), pp. 1, 20040101. | Journal Article
2003
Imidazo[1,2-b]pyridazines, Novel Nucleus with Potent and Broad Spectrum Activity against Human Picornaviruses:  Design, Synthesis, and Biological Evaluation
Hamdouchi, Chafiq⋅Sanchez-Martinez, Concha⋅Gruber, Joseph⋅del Prado, Miriam⋅Lopez, Javier⋅Rubio, Almudena and Heinz, Beverly A
Journal of Medicinal Chemistry, vol. 46, (no. 20), pp. 4341, 20030925. | Journal Article
 
Regioselective Synthesis of 3,6‐Disubstituted‐2‐aminoimidazo[1,2‐a]pyridines
Jaramillo, Carlos⋅Carretero, Juan Carlos⋅de Diego, J. Eugenio⋅del Prado, Miriam⋅Hamdouchi, Chafiq⋅Roldan, Jose Luis and Sanchez‐Martinez, Concha
ChemInform, vol. 34, (no. 7), pp. no, February 18, 2003. | Journal Article
2002
A New Approach to the Synthesis of 2-Aminoimidazo[1,2-a]pyridineDerivatives Through Rapid Parallel Synthesis
Jaramillo, Carlos⋅de Diego, J. Eugenio and Hamdouchi, Chafiq
Synlett, vol. 2002, (no. 9), pp. 1546, 20020902. | Journal Article
 
ChemInform Abstract: A New Approach to the Synthesis of 2‐Aminoimidazo[1,2‐a]pyridine Derivatives Through Rapid Parallel Synthesis
Jaramillo, Carlos⋅de Diego, J. Eugenio and Hamdouchi, Chafiq
ChemInform, vol. 33, (no. 49), pp. no, December 10, 2002. | Journal Article
 
Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2- a]pyridines
Jaramillo, Carlos⋅Carretero, Juan Carlos⋅de Diego, J.Eugenio⋅del Prado, Miriam⋅Hamdouchi, Chafiq⋅Roldán, José Luis and Sánchez-Martı́nez, Concha
Tetrahedron Letters, vol. 43, (no. 50), pp. 9054, 2002. | Journal Article
2000
ChemInform Abstract: New Approach to the Stereoselective Synthesis of the [4.5] Spiroketal Moiety of Papulacandins
Carretero, Juan C⋅de Diego, J. Eugenio and Hamdouchi, Chafiq
ChemInform, vol. 31, (no. 12), pp. no, March 21, 2000. | Journal Article
1999
2-Amino-3-substituted-6-[(E)-1-phenyl-2-(N-methylcarbamoyl)vinyl]imidazo[1,2-a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus:  Stereospecific Synthesis and Antiviral Activity
Hamdouchi, Chafiq⋅de Blas, Jesús⋅del Prado, Mirian⋅Gruber, Joseph⋅Heinz, Beverly A and Vance, Lori
Journal of Medicinal Chemistry, vol. 42, (no. 1), pp. 59, 19990114. | Journal Article
 
A new approach to the synthesis of 2-aminoimidazo[1,2- a]pyridine derivatives through microwave-assisted N-alkylation of 2-halopyridines
Vega, Juan A⋅Vaquero, Juan J⋅Alvarez-Builla, Julio⋅Ezquerra, Jesús and Hamdouchi, Chafiq
Tetrahedron, vol. 55, (no. 8), pp. 2326, 1999. | Journal Article
 
A new stereocontrolled entry into the anthracyclinone families. Part 1: Synthesis of bicyclic precursors of 4-demethoxy-7-deoxy-derivatives
Garcı́a Ruano, José L⋅Garcı́a Paredes, Cristina and Hamdouchi, Chafiq
Tetrahedron: Asymmetry, vol. 10, (no. 15), pp. 2944, 1999. | Journal Article
 
A novel application of the Ullmann coupling reaction for the alkylsulfenylation of 2-amino-imidazo[1,2- a]pyridine
Hamdouchi, Chafiq⋅de Blas, Jesús and Ezquerra, Jesús
Tetrahedron, vol. 55, (no. 2), pp. 548, 1999. | Journal Article
 
ChemInform Abstract: 2‐Amino‐3‐substituted‐6‐ [(E)‐1‐phenyl‐2‐(N‐methylcarbamoyl)vinyl]imidazo‐[1,2‐a]pyridines as a Novel Class of Inhibitors of Human Rhinovirus: Stereospecific Synthesis and Antiviral Activity
Hamdouchi, Chafiq⋅de Blas, Jesus⋅del Prado, Mirian⋅Gruber, Joseph⋅Heinz, Beverly A and Vance, Lori
ChemInform, vol. 30, (no. 21), pp. no, May 25, 1999. | Journal Article