Keywords
- cachexia, muscle, bone, cancer
Areas of Expertise
- cancer cachexia, muscle physiology, muscle pathology, cancer-associated musculoskeletal disease, sarcopenia of aging, IL-6, STAT3, RANKL, chemotherapy toxicities, ovarian cancer, colorectal cancer, tumor-host interactions, muscular dystrophy
Research Interest
- cancer- and chemotherapy-induced musculoskeletal defects
- cancer cachexia
The Bonetto Lab at University of Colorado Anschutz Medical Campus investigates the molecular causes responsible for the onset of muscle and bone complications in cancer (i.e., cachexia).
Our group is actively involved in understanding the musculoskeletal complications resulting from abnormal hepatokine secretion in colorectal cancer to the extent of identifying novel cachexia treatments.
Current projects:
- Role or RANKL in ovarian cancer-induced musculoskeletal complications
- Role of IGFBP1 in the liver-bone-muscle axis in colorectal cancer
- Characterization of cachexia in in vivo models of head and neck cancer
- Effects of pre-existing obesity in cancer-induced cachexia
- Characterization of chemotherapy-induced cachexia
- New mediators of pediatric cancer cachexia
- Regulation of muscle regeneration in cancer
- Identification of novel regulators of muscle and bone loss in aging
I am particularly interested in the effects of chemotherapy on muscle homeostasis and function. By taking advantage of both in vitro and in vivo experimental models, I am investigating whether commonly used chemotherapy regimens can directly affect the skeletal muscle by promoting muscle mass loss, increasing fatiguability and reducing muscle functionality and strength.
Subject areas:
- Cancer in Bone and Muscle
- Muscle/Bone Crosstalk
