Profile - Overview | Scholars@IU

The Yoneda lab focuses on the bone tumor microenvironment, with a particular interest in crosstalk between bone and breast cancer cells in bony metastases. They are also interested in the pathophysiology of cancer-associated bone pain, and the role of microenvironment pH in that process.

My current research interest is the effect of mechanical and electrical stimulation in growth and migration of breast cancer cells. Depending on types and strength of mechano-electrical signals, existing data indicate that biophysical stimuli can induce local and systemic anti-tumor effects. I am interested in developing an adjuvant therapy useful for treatment of bone/brain metastases associated with breast cancer. I am also interested in tumor-bone interactions, in particular, the role of osteocytes and chondrocytes in the presence of mechanical stimulation.

Affiliations

Professor, Department of Biomedical Engineering, School of Engineering and Technology, Indiana University-Purdue University Indianapolis

Member, Indiana Center for Musculoskeletal Health, Centers and Institutes, Indiana University School of Medicine

Member, Transportation Active Safety Institute, School of Engineering and Technology, Indiana University-Purdue University Indianapolis

Member, IU Melvin and Bren Simon Cancer Center, Centers and Institutes, Indiana University School of Medicine

Adjunct Professor, Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine

Professor, Weldon School of Biomedical Engineering, College of Engineering, Purdue University

Past Affiliations

Professor, Weldon School of Biomedical Engineering, College of Engineering, Purdue University (past)

Professor, Department of Mechanical and Energy Engineering, School of Engineering and Technology, Indiana University-Purdue University Indianapolis

Adjunct Faculty, Department of Mechanical Engineering and Energy, School of Engineering and Technology, Indiana University-Purdue University Indianapolis

Associate Professor, Department of Biomedical Engineering, School of Engineering and Technology, Indiana University-Purdue University Indianapolis

Associate Professor, Weldon School of Biomedical Engineering, College of Engineering, Purdue University (past)

Associate Professor, Department of Anatomy and Cell Biology, Indiana University-Purdue University Indianapolis, School of Medicine (past)

Professor, Department of Mechanical Engineering, School of Engineering and Technology, Indiana University-Purdue University Indianapolis

Adjunct Faculty, Department of Mechanical Engineering, School of Engineering and Technology, Indiana University-Purdue University Indianapolis

Associate Professor, Department of Mechanical Engineering, School of Engineering and Technology, Indiana University-Purdue University Indianapolis

Communities

Oncology, Biomedical Engineering, Engineering, Human Anatomy, Cell Biology

Degrees

PhD, Indiana University Bloomington, Molecular, Cellular and Developmental Biology, 1993
PhD, University of Tokyo, Japan, Astronautics, 1983
MS, University of Tokyo, Japan, Astronautics, 1980
BS, University of Tokyo, Japan, Aeronautics and Astronautics, 1978

Keywords

biomedical engineering biomechanics computational biology genomics

Associations

Biomedical Engineering Society

Hiroki Yokota Professor