The Yoneda lab focuses on the bone tumor microenvironment, with a particular interest in crosstalk between bone and breast cancer cells in bony metastases. They are also interested in the pathophysiology of cancer-associated bone pain, and the role of microenvironment pH in that process.
My current research interest is the effect of mechanical and electrical stimulation in growth and migration of breast cancer cells. Depending on types and strength of mechano-electrical signals, existing data indicate that biophysical stimuli can induce local and systemic anti-tumor effects. I am interested in developing an adjuvant therapy useful for treatment of bone/brain metastases associated with breast cancer. I am also interested in tumor-bone interactions, in particular, the role of osteocytes and chondrocytes in the presence of mechanical stimulation.
- control theory/bioinformatics, mechanics, cancer/bone biology
- breast/prostate cancer, bone/brain metastases, osteoporosis, arthritis
Skills and Expertise:
- Gene Expression
- Cancer Biology
- Sports Injuries
- Cell Signaling
- Cancer Cell Biology
- Cancer in Bone and Muscle
- Pediatric Musculoskeletal Disease
- Trauma Regeneration and Rehabilitation