Expertise

Research in my laboratory applies quantitative fluorescence microscopy techniques to visualize the behaviors of proteins inside living cells.  Our studies use the combination of molecular biology, biochemistry, and live-cell imaging approaches to determine how specific signal transduction and gene regulatory complexes are assembled.  We are using time-resolved fluorescence lifetime imaging microscopy (FLIM) to measure Förster resonance energy transfer (FRET), which enables us to determine how certain disease-causing point mutations can affect the assembly of specific protein complexes.  I have over one hundred publications, with extensive experience in live-cell imaging.

My early research focused on how the interactions between cell-specific transcription factors, their co-regulatory protein partners and the nuclear receptors function in concert to regulate gene expression.


Research: Cellular and Molecular Metabolism

Past Affiliations

Member, Center for Diabetes and Metabolic Diseases, Centers and Institutes, Indiana University School of Medicine

Professor, Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine

Associate Professor, Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Virginia Health System, University of Virginia (past)

Associate Professor, Biomedical Sciences Graduate Studies, School of Medicine, University of Virginia Health System, University of Virginia (past)

Associate Professor, Robert M. Berne Cardiovascular Research Center, School of Medicine, University of Virginia Health System, University of Virginia (past)

Associate Professor, Department of Cell Biology, School of Medicine, University of Virginia Health System, University of Virginia (past)

Professor, Department of Cell Biology, School of Medicine, University of Virginia Health System, University of Virginia (past)

Postdoctoral Fellow, University of Iowa

Graduate Student, University of Rochester

Technical Associate, University of Rochester

Assistant Professor, Department of Medicine, School of Medicine, University of Virginia Health System, University of Virginia (past)

Center for Research in Reproduction, School of Medicine, University of Virginia Health System, University of Virginia (past)

Assistant Professor, Department of Medicine, School of Medicine, University of Virginia Health System, University of Virginia (past)

Communities
Human Anatomy, Cell Biology
Degrees
PhD, University of Rochester, Pharmacology, 1987
MS, State University of New York College at Fredonia, Biology, 1980
BS, University of Colorado, Biology/Psychology, 1978
Keywords
pharmacy & pharmacology hormones & endocrinology gene regulation metabolism gene expression internal medicine cell & developmental biology genetics transcription signal transduction
Associations
American Association for the Advancement of Science
Endocrine Society