More recently, Dr. Oakley and her research group have applied their coiled-coil expertise to a fascinating family proteins that contain a long (50 nm) antiparallel coiled coil. These structural maintenance of chromosomes (SMC) proteins are crucial for the faithful organization and segregation of chromosomes in essentially all organisms. The Oakley lab’s initial work has focused on bacterial SMC proteins, with an emphasis on the E. coli condensin, MukB.
- Quantitative Biology and Biophysics
- specific recognition by proteins of biologically relevant ligands; bacterial chromosome segregation; coiled coil proteins; structure and function of condensins and other structural maintenance of chromosomes proteins
- Molecular Life Sciences