38 Publications (Page 1 of 2)
2019
A disulfide-scan of insulin by [3+1] methodology exhibits site-specific influence on bioactivity
Brunel, Florence MBrunel, Florence MMayer, John PMayer, John PGelfanov, Vasily MGelfanov, Vasily MZaykov, Alexander NZaykov, Alexander NFinan, BrianFinan, BrianPerez-Tilve, DiegoPerez-Tilve, DiegoDiMarchi, Richard D and Di Marchi, Richard D
ACS Chemical Biology, vol. 14, (no. 8), pp. 1835, 2019-07-25. | Journal Article
 
Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice
Zaykov, Alexander NZaykov, Alexander NGelfanov, Vasily MGelfanov, Vasily MPerez-Tilve, DiegoPerez-Tilve, DiegoFinan, BrianFinan, BrianDiMarchi, Richard D and Di Marchi, Richard D
Peptides, vol. 120, pp. 170116, October 2019. | Journal Article
 
Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism
Mroz, Piotr AMroz, Piotr AMroz, Piotr AFinan, BrianFinan, BrianFinan, BrianGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyYang, BinYang, BinYang, BinTschöp, Matthias HTschöp, Matthias HTschöp, Matthias HDi Marchi, Richard DDiMarchi, Richard DDiMarchi, Richard DPerez-Tilve, DiegoPerez-Tilve, Diego and Perez-Tilve, Diego
Molecular Metabolism, vol. 20, pp. 62, February 2019. | Journal Article
 
The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis
Bethea, M.Bethea, MaigenBethea, M.Bethea, MaigenBethea, MaigenLiu, Y.Liu, YanpingLiu, YanpingLiu, YanpingLiu, Y.Wade, A.K.Wade, Alexa KWade, Alexa KWade, A.K.Wade, Alexa KMullen, R.Mullen, RachelMullen, RachelMullen, RachelMullen, R.Gupta, R.Gupta, RajeshGupta, RajeshGupta, R.Gupta, RajeshGelfanov, VasilyGelfanov, VasilyGelfanov, V.Gelfanov, VasilyGelfanov, V.Dimarchi, R.Di Marchi, RichardDimarchi, R.DiMarchi, RichardDiMarchi, RichardBhatnagar, S.Bhatnagar, SushantBhatnagar, SushantBhatnagar, SushantBhatnagar, S.Behringer, RichardBehringer, RichardBehringer, R.Behringer, R.Behringer, RichardHabegger, K.M.Habegger, Kirk MHabegger, Kirk MHabegger, Kirk MHabegger, K.M.Hunter, C.S.Hunter, Chad SHunter, Chad SHunter, Chad S and Hunter, C.S.
American journal of physiology. Endocrinology and metabolism, vol. 316, (no. 3), pp. E409, 2019-Mar-01. | Journal Article
2018
Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity
Brandt, Sara JBrandt, Sara JMayer, John PMayer, John PFord, JamesFord, JamesGelfanov, Vasily MGelfanov, Vasily MDiMarchi, Richard D and Di Marchi, Richard D
Peptides, vol. 100, pp. 23, February 2018. | Journal Article
 
High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy
Zaykov, Alexander NZaykov, Alexander NGelfanov, Vasily MGelfanov, Vasily MLiu, FaLiu, FaDiMarchi, Richard D and Di Marchi, Richard D
Organic letters, vol. 20, (no. 12), pp. 3699, 2018-06-15. | Journal Article
 
Structurally Constrained Insulin Analogs by Directed Stepwise Crosslinking
Zhang, FaZhang, FaZhang, FaMayer, JohnMayer, JohnMayer, JohnGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyLiu, FaLiu, FaLiu, FaDiMarchi, RichardDiMarchi, Richard and Di Marchi, Richard
Protein & Peptide Letters, vol. 25, (no. 12), pp. 1154, 20180000. | Journal Article
 
Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5
Zaykov, Alexander NZaykov, Alexander NGelfanov, Vasily MGelfanov, Vasily MLiu, FaLiu, FaDiMarchi, Richard D and Di Marchi, Richard D
ChemMedChem, vol. 13, (no. 8), pp. 859, April 23, 2018. | Journal Article
 
Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink
Thalluri, KishoreThalluri, KishoreThalluri, KishoreMayer, John PMayer, John PMayer, John PChabenne, Joseph RChabenne, Joseph RChabenne, Joseph RGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyDiMarchi, Richard DDi Marchi, Richard D and DiMarchi, Richard D
Communications Chemistry, vol. 1, (no. 1), pp. 7, 2018-12-00. | Journal Article
 
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions
Altindis, EmrahAltindis, EmrahAltindis, EmrahCai, WeikangCai, WeikangCai, WeikangSakaguchi, MasajiSakaguchi, MasajiSakaguchi, MasajiZhang, FaZhang, FaZhang, FaGuoXiao, WangGuoXiao, WangGuoXiao, WangLiu, FaLiu, FaLiu, FaDe Meyts, PierreDe Meyts, PierreMey, PierreGelfanov, VasilyGelfanov, VasilyPan, HuiPan, HuiDi Marchi, RichardDiMarchi, RichardKahn, C Ronald and Kahn, C Ronald
Proceedings of the National Academy of Sciences of the United States of America, vol. 115, (no. 10), pp. 2466, 2018-03-06. | Journal Article
2017
Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless “C-Peptide” Chemical Excision
Thalluri, KishoreThalluri, KishoreThalluri, KishoreThalluri, KishoreKou, BinbinKou, BinbinKou, BinbinKou, BinbinGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyMayer, John PMayer, John PMayer, John PMayer, John PLiu, FaLiu, FaLiu, FaLiu, FaDiMarchi, Richard DDiMarchi, Richard DDiMarchi, Richard D and Di Marchi, Richard D
Organic Letters, vol. 19, (no. 3), pp. 709, 2017-02-03. | Journal Article
 
Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation
Wu, FangzhouWu, FangzhouMayer, John PMayer, John PGelfanov, Vasily GGelfanov, Vasily MLiu, FaLiu, FaDiMarchi, Richard D and Di Marchi, Richard D
The Journal of organic chemistry, vol. 82, (no. 7), pp. 3512, 2017-04-07. | Journal Article
 
Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision
Thalluri, KishoreThalluri, KishoreThalluri, KishoreThalluri, KishoreKou, BinbinKou, BinbinKou, BinbinKou, BinbinYang, XuYang, XuYang, XuYang, XuZaykov, Alexander NZaykov, Alexander NZaykov, Alexander NZaykov, Alexander NMayer, John PMayer, John PMayer, John PMayer, John PGelfanov, Vasily MGelfanov, Vasily MGelfanov, Vasily MGelfanov, Vasily MLiu, FaLiu, FaLiu, FaLiu, FaDi Marchi, Richard DDiMarchi, Richard DDiMarchi, Richard D and DiMarchi, Richard D
Journal of Peptide Science, vol. 23, (no. 6), pp. 465, June 2017. | Journal Article
 
Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity
Liu, FaLiu, FaLiu, FaLi, PengyunLi, PengyunLi, PengyunGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyMayer, JohnMayer, JohnMayer, JohnDi Marchi, RichardDiMarchi, Richard and DiMarchi, Richard
Accounts of chemical research, vol. 50, (no. 8), pp. 1865, 2017-08-15. | Journal Article
2016
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
Finan, B.Finan, BrianFinan, BrianFinan, B.Clemmensen, ChristofferClemmensen, ChristofferClemmensen, C.Clemmensen, C.Zhu, Z.Zhu, Z.Zhu, ZhimengZhu, ZhimengStemmer, K.Stemmer, KerstinStemmer, K.Stemmer, KerstinGauthier, K.Gauthier, KarineGauthier, K.Gauthier, KarineMüller, L.Müller, Timo DMüller, LuisaMüller, L.Müller, LuisaMüller, Timo DDe Angelis, M.De Angelis, MeriDe Angelis, MeriDe Angelis, M.Moreth, K.Moreth, K.Moreth, KristinMoreth, KristinNeff, F.Neff, FraukeNeff, F.Neff, FraukePerez-Tilve, DiegoPerez-Tilve, D.Perez-Tilve, DiegoPerez-Tilve, D.Fischer, KatrinFischer, K.Fischer, KatrinFischer, K.Lutter, DominikLutter, D.Lutter, D.Lutter, DominikSánchez-Garrido, M.A.Sánchez-Garrido, Miguel ASánchez-Garrido, M.A.Sánchez-Garrido, Miguel ALiu, P.Liu, P.Liu, PengLiu, FaLiu, FaLiu, PengTuckermann, J.Tuckermann, JanTuckermann, JanTuckermann, J.Malehmir, M.Malehmir, MohsenMalehmir, M.Malehmir, MohsenHealy, Marc EHealy, M.E.Healy, M.E.Healy, Marc EWeber, A.Weber, AchimWeber, ChristianWeber, AchimWeber, A.Weber, ChristianHeikenwalder, M.Heikenwalder, MathiasHeikenwalder, MathiasHeikenwalder, M.Jastroch, MartinJastroch, MartinJastroch, M.Jastroch, M.Kleinert, M.Kleinert, MaximilianKleinert, M.Kleinert, MaximilianJall, S.Jall, S.Jall, SigridJall, SigridBrandt, S.Brandt, S.Brandt, SaraBrandt, SaraFlamant, F.Flamant, FrédéricFlamant, FrédéricFlamant, F.Schramm, Karl-WernerSchramm, Karl-WernerSchramm, K.-W.Schramm, K.-W.Biebermann, HeikeBiebermann, HeikeBiebermann, H.Biebermann, H.Döring, Y.Döring, YvonneDöring, YvonneDöring, Y.Weber, C.Weber, C.Habegger, K.M.Habegger, Kirk MHabegger, K.M.Habegger, Kirk MKeuper, MichaelaKeuper, M.Keuper, MichaelaKeuper, M.Gelfanov, VasilyGelfanov, VasilyGelfanov, V.Gelfanov, V.Liu, F.Liu, F.Köhrle, J.Köhrle, J.Köhrle, JosefKöhrle, JosefRozman, JanRozman, JanRozman, J.Rozman, J.Fuchs, H.Fuchs, HelmutFuchs, H.Fuchs, HelmutGailus-Durner, ValerieGailus-Durner, V.Gailus-Durner, V.Gailus-Durner, ValerieHrabě de Angelis, MartinHrabě de Angelis, MartinAngelis, M.Angelis, M.Hofmann, Susanna MHofmann, S.M.Hofmann, S.M.Hofmann, Susanna MYang, BinYang, B.Yang, BinYang, B.Tschöp, M.H.Tschöp, Matthias HTschöp, Matthias HTschöp, M.H.DiMarchi, RichardDiMarchi, R.Di Marchi, RichardDiMarchi, R.Müller, T.D. and Müller, T.D.
Cell, vol. 167, (no. 3), pp. 857.e14, 2016-10-20. | Journal Article
 
Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization
Mroz, Piotr AMroz, Piotr AMroz, Piotr APerez-Tilve, DiegoPerez-Tilve, DiegoPerez-Tilve, DiegoLiu, FaLiu, FaLiu, FaGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyDiMarchi, Richard DDiMarchi, Richard DDi Marchi, Richard DMayer, John PMayer, John P and Mayer, John P
Journal of medicinal chemistry, vol. 59, (no. 17), pp. 8067, 2016-09-08. | Journal Article
 
Synthetic Route to Human Relaxin-2 via Iodine-Free Sequential Disulfide Bond Formation
Yang, XuYang, XuGelfanov, VasilyGelfanov, VasilyLiu, FaLiu, FaDiMarchi, Richard and Di Marchi, Richard
Organic letters, vol. 18, (no. 21), pp. 5519, 2016-11-04. | Journal Article
2015
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, BrianFinan, BrianFinan, B.Finan, BrianFinan, B.Finan, BrianFinan, BrianYang, BinYang, BinYang, B.Yang, BinYang, BinYang, B.Yang, BinOttaway, N.Ottaway, NickkiOttaway, NickkiOttaway, NickkiOttaway, NickkiOttaway, NickkiOttaway, N.Smiley, David LSmiley, D.L.Smiley, David LSmiley, D.L.Smiley, David LSmiley, David LSmiley, David LMa, TaoMa, TaoMa, TaoMa, TaoMa, T.Ma, T.Ma, TaoClemmensen, C.Clemmensen, ChristofferClemmensen, ChristofferClemmensen, ChristofferClemmensen, C.Clemmensen, ChristofferClemmensen, ChristofferChabenne, JoeChabenne, JoeChabenne, JoeChabenne, JoeChabenne, JoeChabenne, J.Chabenne, J.Zhang, LianshanZhang, LianshanZhang, LianshanZhang, LianshanZhang, L.Zhang, L.Zhang, LianshanHabegger, Kirk MHabegger, Kirk MHabegger, Kirk MHabegger, K.M.Habegger, K.M.Habegger, Kirk MHabegger, Kirk MFischer, KatrinFischer, K.Fischer, KatrinFischer, KatrinFischer, KatrinFischer, K.Fischer, KatrinCampbell, J.E.Campbell, Jonathan ECampbell, Jonathan ECampbell, Jonathan ECampbell, Jonathan ECampbell, Jonathan ECampbell, J.E.Sandoval, DarleenSandoval, DarleenSandoval, DarleenSandoval, DarleenSandoval, D.Sandoval, DarleenSandoval, D.Seeley, Randy JSeeley, Randy JSeeley, R.J.Seeley, R.J.Seeley, Randy JSeeley, Randy JSeeley, Randy JBleicher, KonradBleicher, KonradBleicher, KonradBleicher, KonradBleicher, K.Bleicher, KonradBleicher, K.Uhles, S.Uhles, SabineUhles, SabineUhles, SabineUhles, S.Uhles, SabineUhles, SabineRiboulet, WilliamRiboulet, WilliamRiboulet, WilliamRiboulet, WilliamRiboulet, W.Riboulet, W.Riboulet, WilliamFunk, J.Funk, JürgenFunk, JürgenFunk, J.Funk, JürgenFunk, JürgenFunk, JürgenHertel, CorneliaHertel, CorneliaHertel, C.Hertel, CorneliaHertel, C.Hertel, CorneliaHertel, CorneliaBelli, SaraBelli, SaraBelli, SaraBelli, SaraBelli, SaraBelli, S.Belli, S.Sebokova, ElenaSebokova, ElenaSebokova, ElenaSebokova, ElenaSebokova, ElenaSebokova, E.Sebokova, E.Conde-Knape, KarinConde-knape, KarinConde-Knape, K.Conde-Knape, KarinConde-Knape, KarinConde-knape, KarinConde-Knape, K.Konkar, AnishKonkar, AnishKonkar, AnishKonkar, AnishKonkar, AnishKonkar, A.Konkar, A.Drucker, Daniel JDrucker, Daniel JDrucker, Daniel JDrucker, D.J.Drucker, Daniel JDrucker, Daniel JDrucker, D.J.Gelfanov, V.Gelfanov, VasilyGelfanov, V.Gelfanov, VasilyGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyPfluger, Paul TPfluger, P.T.Pfluger, Paul TPfluger, Paul TPfluger, Paul TPfluger, Paul TPfluger, P.T.Müller, T.D.Müller, Timo DMüller, Timo DMüller, Timo DMüller, Timo DMüller, Timo DMüller, T.D.Perez-Tilve, DiegoPerez-Tilve, D.Perez-Tilve, DiegoPerez-Tilve, D.Perez-tilve, DiegoPerez-tilve, DiegoPerez-Tilve, DiegoDiMarchi, Richard DDiMarchi, R.D.Dimarchi, Richard DDiMarchi, Richard DDimarchi, Richard DDiMarchi, R.D.Di Marchi, Richard DTschöp, M.H.Tschöp, M.H.Tschöp, Matthias HTschöp, Matthias HTschöp, Matthias HTschöp, Matthias H and Tschöp, Matthias H
Nature medicine, vol. 21, (no. 1), pp. 36, 2015-Jan. | Journal Article
 
Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity
Wu, FangzhouWu, FangzhouChabenne, Joseph RChabenne, Joseph RGelfanov, Vasily MGelfanov, Vasily MMayer, John PMayer, John PDiMarchi, Richard D and Di Marchi, Richard D
Journal of Peptide Science, vol. 21, (no. 3), pp. 230, 2015-03-00. | Journal Article
2014
A glucagon analog chemically stabilized for immediate treatment of life-threatening hypoglycemia
Chabenne, JosephChabenne, JosephChabenne, MariaChabenne, Maria DZhao, YanZhao, YanLevy, JayLevy, Jay ASmiley, DavidSmiley, DavidGelfanov, VasilyGelfanov, VasilyDiMarchi, Richard and Di Marchi, Richard D
Molecular Metabolism, vol. 3, (no. 3), pp. 300, 2014. | Journal Article
 
Chemical Synthesis of Insulin Analogs through a Novel Precursor
Zaykov, Alexander NZaykov, Alexander NMayer, John PMayer, John PGelfanov, Vasily MGelfanov, Vasily MDi Marchi, Richard D and DiMarchi, Richard D
ACS chemical biology, vol. 9, (no. 3), pp. 691, 2014-Mar-21. | Journal Article
2013
A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction
Patterson, JamesPatterson, JamesPatterson, James TLi, PengyunLi, PengyunLi, PengyunDay, Jonathan WDay, JonathanDay, JonathanGelfanov, Vasily MGelfanov, VasilyGelfanov, VasilyDi Marchi, Richard DDiMarchi, Richard and DiMarchi, Richard
Molecular Metabolism, vol. 2, (no. 2), pp. 91, 2013. | Journal Article
 
Discovery of High Potency, Single-Chain Insulin Analogs with a Shortened B-Chain and Nonpeptide Linker
Kaur, Zachary PKaur, Zachary POchman, Alexander ROchman, Alexander RMayer, John PMayer, John PGelfanov, Vasily MGelfanov, Vasily MDi Marchi, Richard D and DiMarchi, Richard D
ACS chemical biology, vol. 8, (no. 8), pp. 1829, 2013-Aug-16. | Journal Article
 
Fibroblast growth factor 21 mediates specific glucagon actions.
Habegger, Kirk MHabegger, K.M.Habegger, K.M.Stemmer, K.Stemmer, K.Stemmer, KerstinCheng, C.Cheng, C.Cheng, ChristineMüller, T.D.Müller, T.D.Müller, Timo DHeppner, K.M.Heppner, K.M.Heppner, Kristy MOttaway, NickkiOttaway, N.Ottaway, N.Holland, J.Holland, JennaHolland, J.Hembree, J.L.Hembree, Jazzminn LHembree, J.L.Smiley, D.Smiley, DavidSmiley, D.Gelfanov, V.Gelfanov, VasilyGelfanov, V.Krishna, R.Krishna, RadhaKrishna, R.Arafat, A.M.Arafat, Ayman MArafat, A.M.Konkar, A.Konkar, A.Konkar, AnishBelli, S.Belli, S.Belli, SaraKapps, M.Kapps, M.Kapps, MartinWoods, Stephen CWoods, S.C.Woods, S.C.Hofmann, SusannaHofmann, S.M.Hofmann, S.M.D’Alessio, D.D'alessio, DavidD’Alessio, D.Pfluger, Paul TPfluger, P.T.Pfluger, P.T.Perez-Tilve, D.Perez Tilve, DiegoPerez-Tilve, D.Seeley, Randy JSeeley, R.J.Seeley, R.J.Konishi, M.Konishi, MorichikaKonishi, M.Itoh, N.Itoh, N.Itoh, NobuyujkiKharitonenkov, A.Kharitonenkov, A.Kharitonenkov, AlexeiSpranger, J.Spranger, J.Spranger, JoachimDi Marchi, Richard DDiMarchi, R.D.DiMarchi, R.D.Tschöp, M.H.Tschoep, MatthiasTschöp, M.H. and Tschöp, Matthias H
Diabetes, vol. 62, (no. 5), pp. 1453-63, 2013/May. | Journal Article
 
Peptide lipidation stabilizes structure to enhance biological function.
Ward, Brian POttaway, Nickki LPerez Tilve, DiegoMa, DejianGelfanov, Vasily MTschöp, Matthias HTschoep, MatthiasDi Marchi, Richard D and Dimarchi, Richard D
Molecular metabolism, vol. 2, (no. 4), pp. 468-79, 2013. | Journal Article